Bilirubin glucuronide is a water-soluble reaction intermediate over the process of conjugation of indirect bilirubin. Bilirubin glucuronide itself belongs...
30 KB (2,694 words) - 12:35, 16 July 2024
Bilirubin di-glucuronide is a conjugated form of bilirubin formed in bilirubin metabolism. The hydrophilic character of bilirubin diglucuronide enables...
4 KB (135 words) - 12:35, 16 July 2024
first to bilirubin glucuronide and then to bilirubin diglucuronide, making it soluble in water: the conjugated version is the main form of bilirubin present...
52 KB (5,367 words) - 07:39, 22 August 2024
baby syndrome. Bilirubin is excreted in the bile as bilirubin diglucuronide (80%), bilirubin glucuronide (20%), and unconjugated bilirubin (< 1%). In the...
17 KB (1,882 words) - 14:14, 7 August 2024
Urine test strip (section Bilirubin test)
with colouration that varies from pink to violet: In acid medium Bilirubin glucuronide + Diazonium salt→ Azo dye (violet) False positive reactions can...
54 KB (6,376 words) - 08:56, 18 May 2024
condition describing an elevation of blood bilirubin level due to the inability to properly metabolise or excrete bilirubin, a product of erythrocytes breakdown...
34 KB (3,363 words) - 14:51, 10 July 2024
residues into bilirubin diglucuronide, and secreted into the small intestine as bile. In the small intestine, some bilirubin glucuronide is converted back...
7 KB (610 words) - 05:23, 19 July 2024
conjugates from hepatocytes into bile. Impaired biliary excretion of bilirubin glucuronides is due to a mutation in the canalicular multiple drug-resistance...
9 KB (855 words) - 18:04, 13 August 2024
inhibition, MRP2 is an apical efflux transporter that mainly exports bilirubin glucuronide and glutathione into bile. However, MRP2 is also the preferential...
112 KB (12,703 words) - 07:34, 10 August 2024
hepatocytes and bacteria) which hydrolyzes bilirubin glucuronides and increases the amount of unconjugated bilirubin in bile. Between 4% and 20% of stones...
42 KB (3,925 words) - 05:18, 16 August 2024
of the white part of the eyes and skin in a newborn baby due to high bilirubin levels. Other symptoms may include excess sleepiness or poor feeding....
31 KB (3,247 words) - 04:00, 12 May 2024
involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid...
7 KB (544 words) - 13:50, 5 June 2024
namely, excessive bilirubin synthesis, liver bilirubin uptake malfunction, and bilirubin conjugation compromise. As to excessive bilirubin synthesis, both...
7 KB (679 words) - 22:07, 1 August 2024
deconjugate bilirubin diglucuronide releasing free bilirubin, which can either be reabsorbed or reduced to urobilinogen by the bacterial enzyme bilirubin reductase...
42 KB (4,371 words) - 08:01, 7 June 2024
conjugated at its 3-hydroxy group into lorazepam glucuronide which is then excreted in the urine. Lorazepam glucuronide has no demonstrable CNS activity in animals...
80 KB (8,524 words) - 05:56, 22 August 2024
Escherichia coli in bile. In humans, the majority of bilirubin is excreted in the bile as bilirubin glucuronide.[citation needed] Hepatolithiasis is associated...
10 KB (999 words) - 00:25, 24 November 2022
pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This...
9 KB (1,071 words) - 02:16, 7 June 2024
activity, may lead to severe toxicity. Also, UGT1A1 conjugates bilirubin and bilirubin glucuronidation is another risk factor for increased toxicity The...
26 KB (2,315 words) - 04:55, 13 April 2024
metabolites via Phase II metabolism by conjugation with sulfate and glucuronide, with a small portion being oxidized via the cytochrome P450 enzyme system...
64 KB (7,237 words) - 20:10, 17 August 2024
lysosome. In the gut, brush border β-glucuronidase converts conjugated bilirubin to the unconjugated form for reabsorption. β-Glucuronidase is also present...
24 KB (2,644 words) - 18:43, 11 December 2023
blood 5-5.7 ×10−4 Bile acids Digestive function, bilirubin excretion 2-30 ×10−6 3-30 ×10−6 Bilirubin Hemoglobin metabolite 2-14 ×10−6 1-10 ×10−6 Biotin...
26 KB (94 words) - 15:48, 20 March 2023
during the first few weeks of life as it interferes with the action of bilirubin and can worsen neonatal jaundice. In HIV-positive people, the combination...
59 KB (6,444 words) - 17:22, 16 August 2024
(ASTTooltip aspartate aminotransferase, ALTTooltip alanine aminotransferase, bilirubin, LDHTooltip lactic dehydrogenase, ALPTooltip alkaline phosphatase), hepatotoxicity...
210 KB (21,561 words) - 03:30, 19 August 2024
product of haem breakdown, bilirubin, most often the result of liver damage as it is the liver's responsibility to clear bilirubin. It tends to produce less...
32 KB (2,742 words) - 06:02, 13 August 2024
(e.g., β-naphthoflavone)) Tapinarof (benvitimod) Tetrapyroles (e.g., bilirubin) Tryptophan derivatives (e.g., indigo dye, indirubin) Antagonists: 7-Ketocholesterol...
118 KB (14,433 words) - 05:50, 27 December 2023
(e.g., β-naphthoflavone)) Tapinarof (benvitimod) Tetrapyroles (e.g., bilirubin) Tryptophan derivatives (e.g., indigo dye, indirubin) Antagonists: 7-Ketocholesterol...
139 KB (13,859 words) - 14:42, 10 July 2024
Docetaxel [D-penicillamine2,5]enkephalin (DPDPE) Enalapril Estradiol-17β-glucuronide 5–25 Estrone-3-sulfate Fexofenadine Fluvastatin Fluo-3 Glutathione (GSH)...
9 KB (1,071 words) - 04:42, 17 June 2024
hydrophilic estrogen conjugates such as estrone sulfate and estradiol glucuronide, which require active transport via specific membrane transport proteins...
103 KB (12,043 words) - 08:45, 18 May 2024
cholestatic jaundice, cholelithiasis, transient increases in transaminases and bilirubin, erythema multiforme, hyperpigmentation, muscle cramps, dysmenorrhea,...
77 KB (7,706 words) - 23:05, 18 May 2024
as well as androstenedione, total testosterone and 3a-androstanediol glucuronide, in young women with PCOS [41,59]. These effects may be due to inhibition...
99 KB (10,959 words) - 06:32, 12 May 2024