• Thumbnail for CD4
    molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). CD4 is found on the surface...
    22 KB (2,581 words) - 20:03, 21 June 2024
  • Thumbnail for T helper cell
    T helper cell (redirect from CD4 T-cell)
    The T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells, are a type of T cell that play an important role in the adaptive immune...
    54 KB (6,597 words) - 14:51, 21 July 2024
  • Thumbnail for T cell
    CD8+ "killer" (cytotoxic) and CD4+ "helper" T cells. (These are named for the presence of the cell surface proteins CD8 or CD4.) CD8+ T cells, also known...
    71 KB (9,061 words) - 12:00, 1 November 2024
  • CD4 immunoadhesin is a recombinant fusion protein consisting of a combination of CD4 and the fragment crystallizable region, similarly known as immunoglobulin...
    23 KB (2,878 words) - 05:00, 2 November 2024
  • The CD4+/CD8+ ratio is the ratio of T helper cells (with the surface marker CD4) to cytotoxic T cells (with the surface marker CD8). Both CD4+ and CD8+...
    11 KB (1,159 words) - 05:00, 2 November 2024
  • Thumbnail for HIV
    helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells. HIV infection leads to low levels of CD4+ T cells through a number of mechanisms...
    123 KB (14,115 words) - 13:33, 14 October 2024
  • Thumbnail for Ford CD4 platform
    The Ford CD4 platform is a Ford global midsize/fullsize automobile platform. The transverse engine platform is designed for either front or all-wheel...
    3 KB (193 words) - 04:35, 12 May 2024
  • Thumbnail for Cytotoxic T cell
    functionally stable TCRs express both the CD4 and CD8 co-receptors and are therefore termed "double-positive" (DP) T cells (CD4+CD8+). The double-positive T cells...
    31 KB (3,843 words) - 10:18, 12 August 2024
  • biomarkers CD4, FOXP3, and CD25 and are thought to be derived from the same lineage as naïve CD4+ cells. Because effector T cells also express CD4 and CD25...
    79 KB (9,481 words) - 19:49, 18 October 2024
  • Thumbnail for Pathophysiology of HIV/AIDS
    influenza-like illness, and then a latent, asymptomatic phase. When the CD4 lymphocyte count falls below 200 cells/ml of blood, the HIV host has progressed...
    14 KB (1,841 words) - 11:04, 2 July 2024
  • Thumbnail for Idiopathic CD4+ lymphocytopenia
    Idiopathic CD4+ lymphocytopenia (ICL) is a rare medical syndrome in which the body has too few CD4+ T lymphocytes, which are a kind of white blood cell...
    12 KB (1,231 words) - 20:49, 15 May 2024
  • subset, similar populations appear to exist for both the helper T cells (CD4-positive) and the cytotoxic T cells. Primary function of memory cells is...
    32 KB (3,781 words) - 12:49, 26 April 2024
  • Thumbnail for HIV/AIDS
    Stage 1: CD4 count ≥ 500 cells/μL and no AIDS-defining conditions Stage 2: CD4 count 200 to 500 cells/μL and no AIDS-defining conditions Stage 3: CD4 count...
    211 KB (21,185 words) - 04:17, 28 October 2024
  • Understanding of the antitumor immunity role of CD4+ T cells has grown substantially since the late 1990s. CD4+ T cells (mature T-helper cells) play an important...
    28 KB (4,000 words) - 05:33, 6 May 2024
  • 26, 2007 Mount Lemmon Mount Lemmon Survey  · 810 m MPC · JPL 567129 2021 CD4 — February 7, 2021 Mount Lemmon Mount Lemmon Survey centaur 9.6 km MPC ·...
    182 KB (659 words) - 16:55, 22 October 2024
  • stage (positive for both CD4 and CD8). The final stage in maturation is the single positive stage (positive for either CD4 or CD8). In humans, circulating...
    21 KB (2,589 words) - 10:38, 12 August 2024
  • that patients who began ART at lower CD4 counts continued to have lower CD4 counts than those who started at higher CD4 counts. When viral suppression on...
    133 KB (15,784 words) - 05:42, 17 September 2024
  • Thumbnail for Cell-mediated immunity
    which the protective function of immunization was associated with cells. CD4 cells or helper T cells provide protection against different pathogens. Naive...
    14 KB (1,381 words) - 19:57, 18 August 2024
  • that secrete IL-12, which stimulates the proliferation of further CD4+ Th1 cells. CD4+ T cells secrete IL-2 and interferon gamma (IFNγ), inducing the further...
    7 KB (508 words) - 10:59, 15 March 2024
  • 15, 1988 Kushiro S. Ueda, H. Kaneda  · 6.0 km MPC · JPL 5115 Frimout 1988 CD4 Frimout February 13, 1988 La Silla E. W. Elst EOS 14 km MPC · JPL 5116 Korsør...
    232 KB (302 words) - 02:20, 16 October 2024
  • Thumbnail for Lymphocyte
    immunodeficiency virus (HIV) infects and destroys T cells (specifically, the CD4+ subgroup of T lymphocytes, which become helper T cells). Without the key...
    23 KB (2,445 words) - 18:22, 18 August 2024
  • Thumbnail for Antigen-presenting cell
    Such cells express MHC class I and MHC class II molecules and can stimulate CD4+ helper T cells as well as cytotoxic T cells. APCs can also present foreign...
    16 KB (2,128 words) - 09:55, 4 March 2024
  • Thumbnail for White blood cell
    destruction. T cells: CD4+ T helper cells: T cells displaying co-receptor CD4 are known as CD4+ T cells. These cells have T-cell receptors and CD4 molecules that...
    32 KB (3,210 words) - 07:13, 7 September 2024
  • Thumbnail for Inflammation
    AIDS-like disease with many parallels to human HIV infection. Delineating how CD4 T cells are depleted and how chronic inflammation and immune activation are...
    94 KB (9,545 words) - 02:59, 25 October 2024
  • Thumbnail for Endoplasmic-reticulum-associated protein degradation
    degrade CD4. CD4 is normally a stable protein and is not likely to be a target for ERAD. However, HIV produces the membrane protein Vpu that binds to CD4. The...
    13 KB (1,709 words) - 07:49, 27 July 2024
  • macrophages express low levels of CD4; dendritic cells express high levels of CD8). Human immunodeficiency virus binds CD4 and a chemokine receptor on the...
    14 KB (1,368 words) - 17:53, 4 September 2024
  • Cancer vaccine targeting CD4+ T cells is a type of vaccine used to treat existing cancer. Cancerous cells usually cannot be recognized by the human immune...
    10 KB (1,518 words) - 19:31, 16 September 2024
  • Thumbnail for SPG21
    identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T...
    4 KB (498 words) - 02:06, 4 March 2023
  • process.[citation needed] CD4, a protein receptor found on the surface of helper T cells in the human immune system, also called CD4+ T cells gp120, a protein...
    9 KB (1,095 words) - 03:47, 25 December 2023
  • Thumbnail for Intraepithelial lymphocyte
    epithelium, these cells can start express also CD8αα. TCRαβ+CD4+ IELs arise from conventional peripheral CD4+ T-cells. These cells migrate into the intestinal epithelium...
    21 KB (2,531 words) - 10:37, 9 January 2024