omega-hydroxylase 2, is an enzyme that in humans is encoded by the CYP4F3 gene. CYP4F3 encodes two distinct enzymes, CYP4F3A and CYP4F3B, which originate...
11 KB (1,316 words) - 23:53, 23 May 2024
superfamily, members of the CYP4A and CYP4F subfamilies viz., CYP4A11, CYP4F2, CYP4F3, are considered the predominant cytochrome P450 enzymes responsible in most...
9 KB (894 words) - 16:39, 17 August 2024
signaling modulators instead for eicosanoid-specific CYP450s, including: CYP4F3 (leukotriene-B4 ω-hydroxylase 2) CYP5A1 (thromboxane-A synthase) CYP8A1...
9 KB (78 words) - 12:31, 1 November 2024
HGNC:20575 Q5TCH4 3895 CYP4B1 HGNC:2644 P13584 3896 CYP4F2 HGNC:2645 P78329 3897 CYP4F3 HGNC:2646 Q08477 3898 CYP4F8 HGNC:2648 P98187 3899 CYP4F11 HGNC:13265 Q9HBI6...
277 KB (17 words) - 18:34, 6 October 2024
Cytochrome P450 microsome ω hydroxylases: CYP4A11, CYP4A22, CYP4F2, and CYP4F3 metabolize arachidonic acid primarily to 20-hydroxyeicosatetraenoic acid...
86 KB (9,651 words) - 06:41, 2 November 2024
DHA to 22-hydroxy-DHA (i.e. 12-HDHA). CYP4F2, CYP4F3A, and CYP4F3B (see CYP4F3 for latter two CYPs) metabolize PUFAs to signaling molecules: they metabolize...
42 KB (4,497 words) - 18:55, 1 October 2024
(CYP450) microsome ω-hydroxylases such as CYP4A11, CYP4A22, CYP4F2, and CYP4F3 in humans, Cyp4a10 and Cyp4a12 in mice, and Cyp4a1, Cyp4a2, Cyp4a3, and...
11 KB (758 words) - 22:34, 18 October 2024
stereoisomers. In humans, the CYP4 ω-hydroxylases include CYP4A11, CYP4F2, and CYP4F3 with the predominant 20-HETE-synthesizing enzymes being CYP4F2, which is...
80 KB (8,942 words) - 10:32, 1 November 2024
chromosome 1p33. CYP4A22 was once considered, along with CYP4A11, CYP4F2, and CYP4F3, as active in metabolizing arachidonic acid to 20-hydroxyeicosatetraenoic...
5 KB (615 words) - 17:50, 11 January 2024
5-prime untranslated sequence. This gene's structure closely resembles CYP4F3. Gene polymorphisms (variants) in CYP4F2 affect liver mRNA levels and enzymatic...
79 KB (8,929 words) - 20:06, 8 August 2024
expressed in the liver and kidney. CYP4A11 along with CYP4A22, CYP4F2, and CYP4F3 metabolize arachidonic acid to 20-Hydroxyeicosatetraenoic acid (20-HETE)...
21 KB (2,570 words) - 14:22, 24 January 2024
cell membranes in functionally important ways. A cytochrome P450, probably CYP4F3, to metabolize 5(S)-HETE to 5(S),20-dihydroxy-eicosatetraenoate (5,20-diHETE)...
48 KB (6,107 words) - 06:42, 13 August 2024
(20-HETE). In humans, the major CYPs making 20-HETE are CYP4A11, CYP4F2, and CYP4F3. In animal models, 20-HETE raises blood pressure by contracting arteries...
48 KB (5,915 words) - 10:25, 22 September 2024
cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F3, is approximately 18 kb away. In addition to seminal vesicles, CYP4F8 is...
10 KB (1,276 words) - 04:55, 15 December 2023
inflammatory responses and the reported associations of certain CYP4F2 and CYP4F3 single nucleotide variants with human Krohn's disease and Coeliac disease...
9 KB (1,124 words) - 04:53, 15 December 2023