membrane insertion mechanism of Perfringolysin O (PFO), a cholesterol-dependent pore-forming cytolysin produced by pathogenic Clostridium perfringens. Instead...
14 KB (1,683 words) - 01:39, 26 March 2023
thiol-activated Cholesterol-dependent Cytolysin (CDC) family (TC# 1.C.12) is a member of the MACPF superfamily. Cholesterol dependent cytolysins are a family...
30 KB (3,525 words) - 06:54, 3 June 2024
categories: Large beta-barrel pore-forming toxins MACPF and Cholesterol-dependent cytolysins (CDCs), gasdermin Binary toxins e.g., Anthrax toxin, Pleurotolysin...
35 KB (4,112 words) - 01:24, 21 April 2024
Cdc42, cell-division cycle protein Cholesterol-dependent cytolysin, exotoxins secreted by bacteria Complement-dependent cytotoxicity Conventional dendritic...
4 KB (499 words) - 04:03, 24 June 2024
around it during cell entry to activate listeriolysin O, a cholesterol-dependent cytolysin capable of disrupting the vacuolar membrane. This frees the...
42 KB (4,779 words) - 01:48, 3 August 2024
cholesterol to be present in the target membrane. Unlike other Cholesterol-dependent cytolysins, SLO contains a 60 Amino acid N-terminal domain that makes...
7 KB (906 words) - 06:23, 14 August 2024
families: the cholesterol-dependent toxins and the RTX toxins. Cholesterol-dependent cytolysins Formation of pores by cholesterol-dependent cytolysins (CDC) requires...
17 KB (2,060 words) - 06:58, 29 January 2024
Trueperella pyogenes becomes a pathogen in the uterus by secreting a cholesterol-dependent cytolysin that damages stromal cells, once the epithelium is damaged...
10 KB (1,030 words) - 15:06, 31 May 2024
Structural studies reveal that MACPF domains are related to cholesterol-dependent cytolysins (CDCs), a family of pore forming toxins previously thought...
21 KB (2,334 words) - 06:15, 27 May 2024
Kulkarni R, Aguilar JL, Lehrer RI, et al. (2011). "Inerolysin, a cholesterol-dependent cytolysin produced by Lactobacillus iners". J Bacteriol. 193 (5): 1034–41...
4 KB (422 words) - 04:43, 12 August 2024
contain a common MACPF domain. This region is homologous to cholesterol-dependent cytolysins from Gram-positive bacteria. The ring structure formed by C9...
9 KB (1,061 words) - 05:28, 8 January 2024
Listeriolysin O is a non-enzymatic, cytolytic, thiol-activated, cholesterol-dependent cytolysin; hence, it is activated by reducing agents and inhibited by...
7 KB (838 words) - 18:00, 5 November 2021
Aguilar JL, Lehrer RI, Ratner AJ (December 2010). "Inerolysin, a cholesterol-dependent cytolysin produced by Lactobacillus iners". Journal of Bacteriology....
96 KB (10,541 words) - 17:22, 10 June 2024
perforin is the MACPF domain. This region shares homology with cholesterol-dependent cytolysins from Gram-positive bacteria. The initial concept of a plasma...
16 KB (1,990 words) - 11:22, 29 June 2024
sometimes these are incomplete. In contrast to PFTs of the cholesterol-dependent cytolysin family, the transition from incomplete lysenin oligomers to...
24 KB (2,790 words) - 20:07, 14 August 2024
family 1.C.14 Cytohemolysin (CHL) family 1.C.39 Thiol-activated cholesterol-dependent cytolysin family 1.C.43 Lysenin family 1.C.56 Pseudomonas syringae HrpZ...
38 KB (5,159 words) - 15:41, 17 April 2024
covalently attached to the lipids glycosylphosphatidylinositol (GPI) and cholesterol. Protein association with membranes through the use of acylated residues...
55 KB (4,391 words) - 16:59, 23 March 2024
The RTX toxin superfamily is a group of cytolysins and cytotoxins produced by bacteria. There are over 1000 known members with a variety of functions....
20 KB (2,540 words) - 22:51, 17 August 2024