(cytosine-5)-methyltransferase 3 beta, is an enzyme that in humans in encoded by the DNMT3B gene. Mutation in this gene are associated with immunodeficiency, centromere...

division cycle associated protein 7 (CDCA7), DNA-methyltransferase 3b (DNMT3B), Lymphoid specific helicase (HELLS) and Zinc finger- and BTB domain containing...

DNMT3b. They found 3,970 regions exclusively enriched for DNMT3a1, 3,838 exclusively enriched for DNMT3a2 and 3,432 exclusively enriched for DNMT3b....

DNMT3A, and DNMT3B) catalyze the addition of methyl groups to cytosines in DNA. While DNMT1 is a maintenance methyltransferase, DNMT3A and DNMT3B can carry...

methyltransferase enzymes, which consists of the protagonists DNMT1, DNMT3A and DNMT3B. While de novo DNA methylation modifies the information passed on by the...

methyltransferase enzymes, which consists primarily of DNMT1, DNMT3A, and DNMT3B. This enzyme is responsible for maintaining DNA methylation, which ensures...

is further crosstalk between DNA methylation carried out by DNMT3A and DNMT3B and histone methylation so that there is a correlation between the genome-wide...

unmethylated DNA at all. Mammalian DNA-methyltransferases DNMT1, DNMT3a and DNMT3b catalyze a reaction of DNA methylation. DNMT1 maintains DNA methylation...

syndrome. Another cause of FSHD2 is mutation in DNMT3B (DNA methyltransferase 3B). Mutations in DNMT3B can also cause ICF syndrome. As of 2020, early evidence...

methyltransferases (DNMTs). There are 5 DNMTs in humans: DNMT1, DNMT2, DNMT3A, DNMT3B, and DNMT3L, and in algae and fungi 3 more are present (DNMT4, DNMT5, and...

DNA methylation in placental development reveals an essential role for DNMT3B". Nat Commun. 14 (1): 371. doi:10.1038/s41467-023-36019-9. PMC 9870994....

HGNC:30373 Q6XZF7 4445 DNMT1 HGNC:2976 P26358 4446 DNMT3A HGNC:2978 Q9Y6K1 4447 DNMT3B HGNC:2979 Q9UBC3 4448 DNMT3L HGNC:2980 Q9UJW3 4449 DNPEP HGNC:2981 Q9ULA0...

modification that often has regulatory effects. Several abnormally spliced DNMT3B mRNAs are found in tumors and cancer cell lines. In two separate studies...

found that polymerase beta recruited the DNA methyltransferase protein DNMT3b to BER repair sites. They then evaluated the methylation pattern at the...

DNMT3A, and DNMT3B) catalyze the addition of methyl groups to cytosines in DNA. While DNMT1 is a “maintenance” methyltransferase, DNMT3A and DNMT3B can carry...

and prevent the activation of cryptic start sites. In mammals, DNMT3a and DNMT3b PWWP domain binds to H3K36me3 and the two enzymes are recruited to the body...

follows an inverse pattern. Other studies with rats found that expression of DNMT3B and other methylation enzymes oscillate with the circadian clock and may...

replication and repair. The upregulation of DNMT3b has also been shown to occur as a result of cigarette exposure. DNMT3b is thought to be critical to de novo...

(which add methyl groups to cytosines at CpG sites), DNMT1, DNMT3A, and DNMT3B, in the pre-implantation embryo up to the blastocyst stage (see Figure)...

it can be transcribed. DNMT1 recruits other DNMTs, including DNMT3A and DNMT3B, which, as a complex, recruit HDAC1. This complex adds methyl groups to...

involved in chromosome condensation. NCAPG has been shown to interact with DNMT3B. GRCh38: Ensembl release 89: ENSG00000109805 – Ensembl, May 2017 GRCm38:...

(June 2023). "Zika virus NS1 suppresses VE-cadherin via hsa-miR-29b-3p/DNMT3b/MMP-9 pathway in human brain microvascular endothelial cells". Cellular...

TM, Sankpal UT, Robertson AK, Zhao Y, Zhao Y, Robertson KD (May 2004). "DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components...

Soukoyan M, Pereira LV (2007). "XIST repression in the absence of DNMT1 and DNMT3B". DNA Research. 12 (5): 373–8. doi:10.1093/dnares/dsi013. PMID 16769694...

humans. It has also been shown that DNMT1 and DNMT3a decrease with aging and DNMT3b increases. Hypomethylation of DNA can lower genomic stability, induce the...

recently it was shown by Duursma and colleagues that miR-148 down regulates Dnmt3b by binding to a region in the protein coding region. Lagos-Quintana, M;...

Sister chromatids prior to Anaphase. SMC2 has been shown to interact with DNMT3B. Mutations in the SMC2 gene have been associated with a variety of human...

D (2015) Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation. Nature 520:243-8 Baubec T, Ivanek R, Lienert F, Schübeler...

S (2004). "DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction". J. Biol. Chem. 279 (26): 27816–23. doi:10...

mediated through the activity of DNA methyltransferases (DNMTs). DNMT3A and DNMT3B regulate de novo methylation of CpG sites, while DNMT1 maintains established...