A degron is a portion of a protein that is important in regulation of protein degradation rates. Known degrons include short amino acid sequences, structural...

preferentially and thus considered destabilizing degrons since they allow faster degradation of their proteins. A degron can be converted into its active form by...

Caltech, has discovered, during the 1980s, the first degradation signals (degrons) in short-lived proteins and biological fundamentals of the ubiquitin system...

1884 snowy regions of Japan by Henri Degron sent to East Asia to seek wild vines resistant to Phylloxera. Degron sent specimens to a Professor Planchon...

missing publisher (link) Varshavsky, Alexander (8 January 2019). "N-degron and C-degron pathways of protein degradation". Proceedings of the National Academy...

signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et...

intrinsic histone acetyltransferase activity. The Neh6 domain may contain a degron that is involved in a redox-insensitive process of degradation of NRF2....

its substrates via short, linear sequence motifs or degrons found in its substrates. These degrons can be split into three major groups: destruction boxes...

available. Biology portal Chemistry portal Amino acid dating Beta-peptide Degron Erepsin Homochirality Hyperaminoacidemia Leucines Miller–Urey experiment...

change from organism to organism. Other degradation signals, known as degrons, can also be found in sequence. The rule may operate differently in different...

long-term cold exposure as a result of inhibition of VRN2 turnover via its N-degron. The events of histone deacetylation at Lysine 9 and 14 followed by methylation...

self-efficient binding of Fbw7 and stable dimerization of cyclin E T380 phospho-degron to Fbw7. Dimerization of β-TrCP1 and β-TrCP2 also found in NH2-terminal...

A (March 2011). "Defining the geometry of the two-component proteasome degron". Nature Chemical Biology. 7 (3): 161–7. doi:10.1038/nchembio.521. PMC 3129032...

Seurat and Pierre Puvis de Chavannes. Through his friend the critic Henry Degron he entered the circle of Maurice Denis and the Nabis, and assiduously attended...

Prediction in human ISLR protein Name Position (aa) Cell Compartment(s) N-degron 1-3 Cytosol Endosome-Lysosome-Basolateral sorting signals 2-7 Cytosol, Endocytic...

Judasova K, Irmisch L, Causemann J, Mansfeld J, et al. (2019-08-02). "Degron-tagged reporters probe membrane topology and enable the specific labelling...

IFNAR1 contains a degron, or a motif for ubiquitination, which allows for its internalization and degradation. Tyk2 may block this degron, preventing its...

stabilization. Sci Adv, 2021. 7(3). Linster, E., et al., Cotranslational N-degron masking by acetylation promotes proteome stability in plants. Nat Commun...

Matthias; Hell, Rüdiger; Wirtz, Markus (2022-02-10). "Cotranslational N-degron masking by acetylation promotes proteome stability in plants". Nature Communications...

yeast monocarboxylate transporter Jen1 acts as a glucose signal–responding degron recognized by the α-arrestin Rod1". Journal of Biological Chemistry. 293...

proteasomal degradation of FoxM1, as expression of a FoxM1 mutant lacking a degron rescued the effects of OGT knockdown. FoxM1 was found not to be directly...

important. Additionally, casein Kinase 1 (CK1) phosphorylates both the Degron region (initiates PER degradation) and the FASP region (antagonistically...

"Tunable and reversible drug control of protein production via a self-excising degron". Nature Chemical Biology. 11 (9): 713–20. doi:10.1038/nchembio.1869. PMC 4543534...

proteins with degron parts that send degradation signals to the cell, inducing metabolic instability. This specific signal is called N-degron, and its causal...

surface of the folded and phosphorylated Sic1, the so-called Cdc4 phospho-degrons (CPD). It has been shown that the optimal consensus sequence for Cdc4 is...

Keun Il; Kim, Kyeong Kyu; Baek, Sung Hee (2012). "EZH2 Generates a Methyl Degron that is Recognized by the DCAF1/DDB1/CUL4 E3 Ubiquitin Ligase Complex"....

Mammalian E3 Ubiquitin Ligases That Contain the UBR Box Motif and Recognize N-Degrons". Mol Cell Biol. 25 (16): 7120–36. doi:10.1128/MCB.25.16.7120-7136.2005...

mechanisms. She collaborated with faculty colleague Nancy Albritton to study degrons of proteolytically cleaved ubiquitins. Waters was involved in mentorship...

endothelial cells; and CARP is degraded by the 26S proteasome via a PEST degron. In animal models of disease and injury, CARP has been characterized to...

mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons". Mol Cell Biol. 25 (16): 7120–7136. doi:10.1128/MCB.25.16.7120-7136.2005...