Half maximal effective concentration (EC50) is a measure of the concentration of a drug, antibody or toxicant which induces a biological response halfway...
9 KB (1,023 words) - 21:43, 27 August 2024
IC50 is comparable to other measures of potency, such as EC50 for excitatory drugs. EC50 represents the dose or plasma concentration required for obtaining...
10 KB (1,084 words) - 20:25, 28 August 2024
inversely related to its half maximal effective concentration (EC50) value. The EC50 can be measured for a given agonist by determining the concentration...
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potential channels TRPA1 (EC50 = 700 nM), TRPV1 (EC50 = 1,300 nM), TRPV2 (EC50 = 1,720 nM), TRPV3 (EC50 = 1,000 nM), and TRPV4 (EC50 = 5,100 nM) (efficacy...
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Threshold dose (section EC50)
toxicology, there are some other safety factors including LD50, LC50 and EC50. Threshold dose is a dose of drug barely adequate to produce a biological...
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the CB1 receptors with an EC50 of 44.4nM for 9R-HHCP and 134nM for 9S-HHCP. Compared to Hexahydrocannabinol (HHC) with an EC50 of 101nM for 9R-HHC and 1...
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as a strong non-competitive selective NMDA receptor antagonist, with an EC50 of 20 μM; which might promote sedation in addition with the strong antihistaminergic...
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as EC50, IC50, ED50, etc.) and measures of efficacy (such as tissue, cell or population response). A commonly used dose–response curve is the EC50 curve...
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compared to D9-THC (1.6x). 9R-HHC has an EC50 of 3.4nM ± 1.5nM at CB1 and 6.2nM ± 2.1nM at CB2 while 9S-HHC has an EC50 of 57nM ± 19nM at CB1 and 55nM ± 10nM...
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inhibition at CB1 it displays a similar efficacy to that of Δ9-THC (EC50 = 11 nM vs. EC50 = 5.2 nM, respectively), but a lower maximum response (Emax = 28%...
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the 5-HT2A receptor, with an EC50 of 185.7 nM and an efficacy of 28.7% (vs 5-HT), and a full agonist at 5-HT2C with an EC50 of 89.7 nM and an efficacy of...
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(Ki = 0.9 nM; EC50 = 13.0 nM; IATooltip intrinsic activity = 89%) and κ-opioid receptor (Ki = 2.6 nM; EC50 = 17 nM; IA = 67%). The EC50 values of 0.5–5...
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eliciting 50% of its maximal effect (half maximal effective concentration = EC50) at the human 5-HT2A receptor in vitro are in the 0.118–0.983 μmol/L range...
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on binding affinity. Potency of drug is the measure of its effectiveness, EC50 is the drug concentration of a drug that produces an efficacy of 50% and...
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EK45 Westover March 9, 2000 Socorro LINEAR · 4.0 km MPC · JPL 17237 2000 EC50 — March 7, 2000 Višnjan Observatory K. Korlević · 2.9 km MPC · JPL 17238...
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inserting a letter after the digit and before the space: EC1–EC4 (but not EC50), SW1, W1, WC1, WC2 and parts of E1 (E1W), N1 (N1C and N1P), NW1 (NW1W) and...
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among individual plants and populations.}}}} Notes: In brackets is the IC50/EC50 value depending on whether it is an inhibitory or inductive action being...
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estrogen-related receptor (ERR) agonist, acting most strongly at ERRα with an EC50 of 98 nM. It was found to counteract metabolic syndrome in mice, suggesting...
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Guinea pig σ2 136 Agonist Rat D2 >10,000 ND Human D2High 2.7–4.3 144 (EC50) Partial Agonist Rat/human Human 5-HT2A >10,000 ND Human 5-HT2AHigh ≥5...
57 KB (5,436 words) - 20:08, 25 August 2024
HCN1Tooltip Hyperpolarization-activated cyclic nucleotide-gated channel 1 8–16 EC50 Inhibitor Mouse TRPV1 1-100 Ki Agonist Rat The smaller the value, the stronger...
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at which there is a 50% effect (ex. EC50) for a certain biological endpoint. One toxic unit is equal to the EC50 for a given endpoint for a specific biological...
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Protective index Median toxic dose (TD50) Lowest published lethal dose (LDLo) EC50 (half maximal effective concentration) IC50 (half maximal inhibitory concentration)...
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interactions with the other serotonin receptors. Whereas vortioxetine has IC50 or EC50 values of 5.4 nM for the SERT and 12 nM for the 5-HT3 receptor, its values...
56 KB (4,803 words) - 19:52, 31 August 2024
comparing the change in the dose ratio, the ratio of the EC50 of an agonist alone compared to the EC50 in the presence of a competitive antagonist as determined...
33 KB (3,845 words) - 01:47, 19 August 2024
activity of solriamfetol at human, mouse, and rat TAAR1 receptors. hTAAR1 EC50 values (10–16 μM) were within the clinically observed therapeutic solriamfetol...
134 KB (12,303 words) - 05:26, 2 September 2024
act as a partial agonist of the κ-opioid receptor at high concentrations (EC50 = 7.2 μM). Antagonism of the α2-adrenergic receptors, which function largely...
87 KB (7,810 words) - 18:36, 1 September 2024
15,000 HDAC9 2,000,000 Lower bound CA1 511,000 CA2 1,032,000 GPCR target pEC50 Entry note FFAR2 2.9–4.6 Full agonist FFAR3 3.8–4.9 Full agonist HCA2 2.8...
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lower trace is recorded at an agonist concentration near this ion channel's EC50. Channel openings are represented by downward deflections, in this case deflections...
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estrogen receptors with Ki values of 1.1 μM and 0.5 μM, respectively, and EC50 values of >1 μM and 200 nM, respectively. Though it was found to be a partial...
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L-norpseudoephedrine acts as a releasing agent of norepinephrine (EC50 = 30 nM) and to a lesser extent of dopamine (EC50 = 294 nM). Due to the 10-fold difference in its...
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