Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a potent vasoconstrictor peptide produced by vascular endothelial cells, as well as...

genes for endothelin-1 (ET-1), endothelin-2 (ET-2), and endothelin-3 (ET-3) are located on chromosomes 6, 1, and 20, respectively. Endothelin functions...

hormones; angiotensin II, endothelin-1 and the catecholamines (e.g. noradrenaline).[citation needed] Angiotensin-II and endothelin-1 are hormones that bind...

An endothelin receptor antagonist (ERA) is a drug that blocks endothelin receptors. Three main kinds of ERAs exist: Dual ET Receptor Antagonists, which...

prediabetes or Type 2 diabetes mellitus. Oxytocin (OXT) Omentin Endothelin-1 Nesfatin-1 Irisin Betatrophin Hepatocyte growth factor (HGF) Fibroblast growth...

vasodilation. Endothelin receptor antagonists cause vasodilation as well by blocking the action of the potent vasoconstrictor endothelin-1. Prostacyclins...

Endothelin-converting enzyme 1 (EC 3.4.24.71, endothelin-converting enzyme, ECE-1) is an enzyme. This enzyme catalyses the following chemical reaction...

the brand name Tyvalzi) is a synthetic analog of endothelin-1 that works as a selective endothelin-B receptor agonist. In May 2023, it was approved in...

antagonist that inhibits the protein endothelin-1 from binding to endothelin A and endothelin B receptors. Endothelin-1 mediates various adverse effects via...

activity) decreases. Endothelin-1 is a peptide (comprising 21 amino acids) that is produced in endothelial cells. It acts on the endothelin receptors ETA and...

and endothelin-1 in delayed cerebral vasospasm produced by aneurysmal subarachnoid hemorrhage". Nature Clinical Practice Cardiovascular Medicine. 1 (2):...

decrease collagen degradation and increase extracellular matrix production. Endothelin signalling is implicated in the pathophysiology of fibrosis. Vitamin D...

Macitentan, sold under the brand name Opsumit, is an endothelin receptor antagonist developed by Actelion and approved for the treatment of pulmonary arterial...

There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose activation result in elevation...

The pineal gland contains receptors for the regulatory neuropeptide, endothelin-1, which, when injected in picomolar quantities into the lateral cerebral...

1988 by Yanagisawa and team and belongs to a family of three endothelin peptide isoforms (ET-1, ET-2, ET-3), which constrict blood vessels. ET-2 is encoded...

Bosentan, sold under the brand name Tracleer among others, is a dual endothelin receptor antagonist medication used in the treatment of pulmonary artery...

Endothelin receptor type A, also known as ETA, is a human G protein-coupled receptor. Endothelin receptor type A has been shown to interact with HDAC7A...

"neuropeptide/cerebral vasoconstriction" theory, some specific substances (endothelin 1, thromboxane A2) trigger spasm of the blood vessels with resultant vessel...

carotid artery occlusion (in some species only) Focal cerebral ischemia Endothelin-1-induced constriction of arteries and veins Middle cerebral artery occlusion...

magic mushroom extracts on endothelin-1-induced hypertrophy and cell injury in cardiomyocytes". Scientific Reports. 10 (1): 22314. doi:10.1038/s41598-020-79328-5...

peptide stimulates thymidine incorporation in endothelial cells: role of endothelin-1". Am. J. Physiol. Endocrinol. Metab. 285 (2): E390–6. doi:10.1152/ajpendo...

Meens MJ (2009). "Endothelin-1, an Endogenous Irreversible Agonist in Search of an Allosteric Inhibitor". Mol Cell Pharmacol. 1 (5): 246–257. Rosenbaum...

investigate endothelin-1 posttranscriptional regulation". Experimental Biology and Medicine. 231 (6): 704–708. doi:10.3181/00379727-231-2310704 (inactive 1 November...

restricted for six weeks showed an endothelin 1 (ET-1) decrease of 14% associated with a 45% increase in FMD. ET-1 has autocrine action on endothelial...

angiotensin-11, endothelin-1, and alpha-adrenergic agonists. Various vasoactive agents, such as prostanoids, phosphodiesterase inhibitors, and endothelin antagonists...

Bobadilla NA, Halhali A (2007). "[Endothelin 1 and angiotensin II in preeeclampsia]". Revista de Investigacion Clinica. 59 (1): 48–56. PMID 17569300. Wikimedia...

and thromboxane (from Kupffer Cells) or nitric oxide (NO) and endothelin-1 (ET-1). ET-1 is the most potent vasoconstrictor under investigation and it...

Endothelin-3 is a protein that in humans is encoded by the EDN3 gene. The protein encoded by this gene is a member of the endothelin family. Endothelins...

cardiac hypertrophy signaling, Wnt signaling, Notch signaling, and endothelin 1 signaling. Of the 16 genes identified in these pathways, three were found...