Endothelin receptor type A, also known as ETA, is a human G protein-coupled receptor. Endothelin receptor type A has been shown to interact with HDAC7A...

There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose activation result in elevation...

An endothelin receptor antagonist (ERA) is a drug that blocks endothelin receptors. Three main kinds of ERAs exist: Dual ET Receptor Antagonists, which...

Endothelins are peptides with receptors and effects in many body organs. Endothelin constricts blood vessels and raises blood pressure. The endothelins...

Endothelin receptor type B, (ET-B) is a protein that in humans is encoded by the EDNRB gene. Endothelin receptor type B is a G protein-coupled receptor...

an endothelin receptor antagonist developed by Actelion and approved for the treatment of pulmonary arterial hypertension (PAH). Macitentan is a dual...

subsequently to mature endothelin, which the cells release. Patients with salt-sensitive hypertension have higher plasma ET-1. Endothelin-1 receptor antagonists...

Bosentan, sold under the brand name Tracleer among others, is a dual endothelin receptor antagonist medication used in the treatment of pulmonary artery...

both endothelin A and endothelin B receptors. Aprocitentan was approved for medical use in the United States in March 2024. It is the first endothelin receptor...

different G-protein coupled receptors (GPCRs), the endothelin A receptor (EDNRA) and the endothelin B receptor (EDNRB). As ET-2 has a very similar homology...

among others, is a drug used for the treatment of pulmonary hypertension. It is an endothelin receptor antagonist. The peptide endothelin constricts muscles...

EtBr may refer to: Bromoethane Endothelin_B_receptor (when written as ETBR) Ethidium bromide This disambiguation page lists articles associated with the...

toxicity. Sitaxentan is a small molecule that blocks the action of endothelin (ET) on the endothelin-A (ETA) receptor selectively (by a factor of 6000 compared...

precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development...

term. The disease has a similar cause to Hirschsprung's disease in humans. A mutation in the middle of the endothelin receptor type B (EDNRB) gene causes...

under the brand name Tyvalzi) is a synthetic analog of endothelin-1 that works as a selective endothelin-B receptor agonist. In May 2023, it was approved...

also being investigated as a therapy for diabetic kidney disease. It is an endothelin receptor antagonist selective for subtype A (ETA). While other drugs...

hormones that bind to the angiotensin (AT) and endothelin (ET) receptors. These are G-protein coupled receptors that act via internal signalling pathways....

and also called H2 blockers, are a class of medications that block the action of histamine at the histamine H2 receptors of the parietal cells in the stomach...

(INN, brand name Pivlaz) is a drug belonging to the class of endothelin receptor antagonists. The endothelin 1 receptor is one of the strongest known...

sensorineural deafness. The syndrome is caused by mutation in the endothelin B receptor gene (EDNRB). In the beginning, medical officials defined ABCD syndrome...

vasoconstriction, including the release of vasoconstrictor substances such as endothelin and angiotensin II, both of which play crucial roles in the modulation...

peptide receptor is a type of receptor which binds one or more signaling peptides or signaling proteins. An example is the tropomyosin receptor kinase...

and Training Board, a public body in Ireland Endothelin B receptor, a protein Equitorial Trust Bank, a Nigerian commercial bank Etebi language of Nigeria...

2007 Metallinos DL, Bowling AT, Rine J (Jun 1998). "A missense mutation in the endothelin-B receptor gene is associated with Lethal White Foal Syndrome:...

Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the plasma membrane of cells. They act in cell...

protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G...

adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that binds epinephrine (adrenaline), a hormone...

receptor (NMBR) Gastrin-releasing peptide receptor (GRPR) Endothelin receptor InterPro: IPR000499 Endothelin receptor type A (EDNRA, ET1R) Endothelin...

It is an endothelin receptor antagonist. Zibotentan was granted fast track status for the treatment of prostate cancer by the FDA. It failed a phase III...