Farnesyltransferase (EC 2.5.1.58) is one of the three enzymes in the prenyltransferase group. Farnesyltransferase (FTase) adds a 15-carbon isoprenoid...

The farnesyltransferase inhibitors (FTIs) are a class of experimental cancer drugs that target protein farnesyltransferase with the downstream effect of...

methylation. Carboxyl methylation only occurs on prenylated proteins. Farnesyltransferase and geranylgeranyltransferase I are very similar proteins. They consist...

1126/science.1153018. PMC 2747771. PMID 18276850. Farnesyl-Diphosphate+Farnesyltransferase at the U.S. National Library of Medicine Medical Subject Headings...

triggers three sequential enzymatic modifications. First, protein farnesyltransferase catalyzes the addition of a farnesyl moiety to the cysteine. Second...

systematic name (2E,6E)-farnesyl-diphosphate:(2E,6E)-farnesyl-diphosphate farnesyltransferase (presqualene diphosphate forming). This enzyme catalyses the following...

Farnesyl-diphosphate farnesyltransferase 1 is a protein that in humans is encoded by the FDFT1 gene. This gene encodes a membrane-associated enzyme located...

name Zarnestra) is a farnesyltransferase inhibitor. Farnesyltransferase inhibitors block the activity of the farnesyltransferase enzyme by inhibiting...

Protein farnesyltransferase subunit beta is an enzyme that in humans is encoded by the FNTB gene. GRCm38: Ensembl release 89: ENSMUSG00000033373 – Ensembl...

manipulate the regulation of the above-mentioned localization of Ras. Farnesyltransferase inhibitors have been developed to stop the farnesylation of Ras and...

affinity modulator Sickle cell disease 2019 Lonafarnib (Zokinvy) Farnesyltransferase inhibitor Hutchinson-Gilford progeria syndrome 2020 2022 Dupilumab...

Australia Fair Trials International, a British human rights organization Farnesyltransferase inhibitor, a class of cancer drugs Federation of Thai Industries...

midazolam and certain cholesterol-lowering medications. Lonafarnib, a farnesyltransferase inhibitor, is an oral medication that helps prevent the buildup of...

an Ala, Met, Ser or Gln the protein will be farnesylated via the farnesyltransferase enzyme and if the X is a Leu then the protein will be geranylgeranylated...

are used infrequently in English. Sebti; Hamilton, eds. (2001). Farnesyltransferase inhibitors in cancer therapy. p. 126. ISBN 9780896036291. Retrieved...

as drug R115777) inhibits the activation of RAS. This drug is a Farnesyltransferase inhibitor which inhibits the Ras kinase in a post translational modification...

onto the C-terminal consensus sequence CAAL (somewhat similar to farnesyltransferase reactions), where C=cysteine, A=any aliphatic amino acid, and L=leucine...

treatment he devised for children affected by Progeria. He discussed how farnesyltransferase inhibitors (FTIs) affects H-Ras. After his presentation, members...

enzyme with systematic name farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase (4,4'-diapophytoene forming). This enzyme catalyses the following...

Ghassemian M, Kwak CM, McCourt P, & Schroeder JI (1998) Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss...

Protoheme IX farnesyltransferase, mitochondrial is an enzyme that in humans is encoded by the COX10 gene. Cytochrome c oxidase (COX), the terminal component...

prompted intense pharmaceutical industry pursuit of inhibitors of the farnesyltransferase enzyme that catalyzes this lipid modification on RAS and other proteins...

being translated, a farnesol is added to prelamin A using protein farnesyltransferase; this farnesylation is important in targeting lamin to the nuclear...

COMT Thymidylate synthase 2.4 PARP 2.5 Dihydropteroate synthetase Farnesyltransferase 2.6 GABA transaminase 2.7 Nucleotidyltransferase Integrase Reverse...

random screening of natural extracts. Clavaric acid is a reversible farnesyltransferase inhibitor with an IC50 of 1.3 μM. Lingham RB, Silverman KC, Jayasuriya...

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha is an enzyme that in humans is encoded by the FNTA gene. Prenyltransferases...

protein F-box protein 16 FDFT1 encoding protein Farnesyl-diphosphate farnesyltransferase 1 FGFR1: fibroblast growth factor receptor 1 (fms-related tyrosine...

attack on the geranylgeranyl diphosphate, displacing the diphosphate. Farnesyltransferase Prenylation Rab geranylgeranyltransferase – Geranylgeranyltransferase...

Reiss Y, Casey PJ, Brown MS, Goldstein JL (May 1991). "Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit". Cell...

basis for the development of anticancer drugs due to their strong farnesyltransferase inhibitory effects. A series of alkyl- and alkenyl-itaconates, known...