oxytosis and ferroptosis are today thought to be the same cell death mechanism. Researchers have identified roles in which oxytosis/ferroptosis can contribute...

levels. ALOX5-mediated ferroptosis acts as a cell death pathway upon oxidative stress in Huntington's disease. Inhibitors of ferroptosis are protective in...

disease progression, an iron-dependent form of regulated cell death called ferroptosis could be involved. Products of lipid peroxidation are also elevated in...

Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, et al. (May 2012). "Ferroptosis: an iron-dependent form of nonapoptotic cell death". Cell. 149 (5): 1060–1072...

balance of these enzymes a central regulator of ferroptosis. Chelation of iron also inhibits ferroptosis, possibly by depleting iron from lipoxygenases...

membrane permeabilization and ferroptosis in breast cancer. While mesenchymal breast cancer cells are vulnerable to ferroptosis, ironomycin and salinomycin...

cornification, a form of cell death exclusive to the eyes; excitotoxicity; ferroptosis, an iron-dependent form of cell death and Wallerian degeneration. Plant...

process of ferroptosis, coined the term ferroptosis, described its key mechanisms, and developed the first chemical probes to control ferroptosis. In 2014...

therefore, fueling further neuroinflammation by activating microglia. Ferroptosis is suggested as another significant mechanism in disease progression...

which indirectly protect tumor cells from ferroptosis ('iron death'), emphasizing the need for ferroptosis inducers (thiostrepton) for cancer treatment...

mitochondrial DNA copy number. XJB-5-131 also strongly protects against ferroptosis, a form of iron-dependent regulated cell death. Xun Z, Rivera-Sánchez...

; Mourão, André (November 2019). "FSP1 is a glutathione-independent ferroptosis suppressor". Nature. 575 (7784): 693–698. Bibcode:2019Natur.575..693D...

Sadovsky, H Bayır, Y Tyurina, R He, V Kagan "iPLA2G6 Protects Cells against Ferroptosis by Hydrolyzing the Lipid Signal of Death, 15-HpETE-PE: Relevance to Parkinson...

were found to have a secondary role protecting against cell death by ferroptosis in cellular models by limiting the formation of toxic lipid peroxides...

cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis". eLife. 3: e02523. doi:10.7554/eLife.02523. PMC 4054777. PMID 24844246...

(April 2022). "COVID-19-Related Brain Injury: The Potential Role of Ferroptosis". Journal of Inflammation Research. 15: 2181–2198. doi:10.2147/JIR.S353467...

alkyl chains have been shown to promote or inhibit the cell death from ferroptosis, depending on their degree of saturation. During inflammation, neutrophil-derived...

cornification, a form of cell death exclusive to the epidermis; excitotoxicity; ferroptosis, an iron-dependent form of cell death and Wallerian degeneration. Necroptosis...

Kagan VE, Schick JA, Conrad M (17 November 2014). "Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice". Nature Cell Biology...

peroxidation in the aging retina, and their intimate role in ferroptosis, have implicated ferroptosis in AMD pathogenesis. A plethora of in vivo risk factors...

Skidmore J, Devos D, Hammond TR (2023). "Therapeutic inhibition of ferroptosis in neurodegenerative disease". Trends in Pharmacological Sciences. 44...

cumulatively lead to cell death. Prolonged store depletion can protect against ferroptosis via remodeling of ER-synthesized phospholipids. Thapsigargin treatment...

location protects the omega−3 fatty acid from lipid peroxidation and ferroptosis. This table lists several different names for the most common omega−3...

leukemia U937 cells. Autolysis Autophagy Cisplatin Cytotoxicity Entosis Ferroptosis Homeostasis Immunology Necrobiosis Necrosis Necrotaxis Nemosis Mitotic...

three main mechanisms: necroptosis via RIPK1, FADD, RIPK3, and MLKL, ferroptosis via GPX4 suppression, system Xc suppression, and NAPDH loss, as well...

Apoptosis-inducing factor 2 (AIFM2), also known as ferroptosis suppressor protein 1 (FSP1), apoptosis-inducing factor-homologous mitochondrion-associated...

2023). "Sigma Receptors: Novel Regulators of Iron/Heme Homeostasis and Ferroptosis". International Journal of Molecular Sciences. 24 (19): 14672. doi:10...

(April 2022). "COVID-19-Related Brain Injury: The Potential Role of Ferroptosis". J Inflamm Res. 15: 2181–2198. doi:10.2147/JIR.S353467. PMC 8994634...

and tetrahydrobiopterin were found to protect against cell death by ferroptosis. Tetrahydrobiopterin (BH4) acts as a potent, diffusable antioxidant that...

novel transcriptional and epigenetic strategies for limiting neuronal ferroptosis which have identified novel small molecule approach which have been validated...