channel 4 is a protein that in humans is encoded by the HCN4 gene. There are four HCN channels. HCN4 is prominently expressed in the pace maker region of...
11 KB (1,313 words) - 00:06, 18 August 2023
(hyperpolarization-activated cyclic nucleotide–gated channel), of which 4 isoforms (HCN1 to HCN4) are known. Based on their sequence, HCN channels are classified as members...
10 KB (1,195 words) - 21:33, 8 November 2023
activation, faster activation kinetics, and a lower sensitivity to cAMP, while HCN4 channels are slowly gating and strongly sensitive to cAMP. HCN2 and HCN3...
14 KB (1,568 words) - 07:22, 3 July 2024
congestive heart failure with reduced ejection fraction. Ivabradine binds to HCN4 receptors (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated...
24 KB (2,411 words) - 18:57, 15 August 2024
hyperpolarization-activated cyclic nucleotide-gated channels genes (HCN1, HCN2, HCN3 and HCN4). Anti epileptic drugs: most evidence suggests that antiepileptic drugs are...
24 KB (2,710 words) - 12:54, 23 August 2024
transduction. CNBD1; CNGA1; CNGA2; CNGA3; CNGB1; CNGB3; HCN1; HCN2; HCN3; HCN4; KCNH1; KCNH2; KCNH3; KCNH4; KCNH5; KCNH6; KCNH7; KCNH8; PNPLA6; PNPLA7;...
4 KB (327 words) - 22:46, 2 May 2024
Jean-François; Shi, Nian-Qing; McLaughlin, Kelly A; Levin, Michael (2017). "HCN4 ion channel function is required for early events that regulate anatomical...
173 KB (17,264 words) - 08:00, 8 May 2024
HGNC:4845 O60741 6953 HCN2 HGNC:4846 Q9UL51 6954 HCN3 HGNC:19183 Q9P1Z3 6955 HCN4 HGNC:16882 Q9Y3Q4 6956 HCRT HGNC:4847 O43612 6957 HCRTR1 HGNC:4848 O43613...
277 KB (17 words) - 15:46, 9 May 2024
SLC9A10; SLC9A11 CNGA1; CNGA2; CNGA3; CNGA4 CNGB1; CNGB3 HCN1; HCN2; HCN3; HCN4 ITPR1; ITPR2; ITPR3 HVCN1 TPTE, part of the larger Voltage sensitive phosphatase...
19 KB (1,692 words) - 03:53, 29 November 2023
encoded by the HCN2 gene. HCN2 has been shown to interact with HCN1 and HCN4. The function of the channel is not known although its activation by hyperpolarization...
9 KB (1,098 words) - 03:06, 19 August 2024
Ground reaction force Gs alpha subunit Gunther O. Hofmann HCN1 HCN2 HCN3 HCN4 HCN channel HERG HTR3A HTR3B HTR3C HTR3D HTR3E HVCN1 Hal Anger Hans Frauenfelder...
15 KB (1,545 words) - 18:32, 17 August 2024
nM, which is comparable to the affinities reported for PKA (100 nM) and HCN4 (240 nM). One of the interacting proteins is the two-pore potassium (K2P)...
4 KB (511 words) - 22:19, 3 March 2023
613119; KCNE3 Brugada syndrome 7; 613120; SCN3B Brugada syndrome 8; 613123; HCN4 Brunner syndrome; 300615; MAOA Burkitt's lymphoma; 113970; MYC Buschke–Ollendorff...
234 KB (18,877 words) - 15:43, 9 May 2024
miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart". The Journal of Biological Chemistry. 283 (29): 20045–52...
13 KB (1,530 words) - 15:18, 19 June 2024
in the sinus node leads to downregulation of the pacemaker ion channel, HCN4, and thus downregulation of the corresponding ionic current, which causes...
9 KB (1,005 words) - 01:50, 11 December 2023