Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene. Histone acetylation and deacetylation, catalyzed by multisubunit...
50 KB (5,476 words) - 01:27, 4 January 2024
other Class I HDACs could compensate for the loss of HDAC1. This inability to recover from HDAC1 KO leads researchers to believe that there are both functional...
58 KB (7,036 words) - 21:48, 28 February 2024
in the absence of HDAC1. Their study also found a regulatory crosstalk between HDAC1 and HDAC2 and suggest a novel function for HDAC1 as a transcriptional...
31 KB (3,181 words) - 07:12, 12 August 2024
certain genes (eg, cdk5) and repress others (eg, c-fos) where it recruits HDAC1 as a corepressor. ... Chronic exposure to psychostimulants increases glutamatergic...
151 KB (14,842 words) - 09:53, 16 August 2024
butyrate is an agonist of HCA2. It is also an HDAC inhibitor (specifically, HDAC1, HDAC2, HDAC3, and HDAC8), a drug that inhibits the function of histone...
65 KB (6,428 words) - 03:51, 25 June 2024
DIM has action as a histone deacetylase inhibitor, specifically against HDAC1, HDAC2, and HDAC3. DIM is a metabolite of indole-3-carbinol. DIM was found...
6 KB (350 words) - 03:34, 30 October 2023
itself inhibits class I histone deacetylase (HDAC) activity, specifically HDAC1, HDAC2, HDAC3, and butyrate can be used in determining histone deacetylene...
5 KB (436 words) - 13:46, 24 January 2024
certain genes (eg, cdk5) and repress others (eg, c-fos) where it recruits HDAC1 as a corepressor. ... Chronic exposure to psychostimulants increases glutamatergic...
273 KB (26,879 words) - 20:36, 4 August 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
26 KB (2,884 words) - 11:10, 20 July 2024
enzymes are drugs that inhibit four specific histone-modifying enzymes: HDAC1, HDAC2, HDAC3, and HDAC8. Most of the animal research with HDAC inhibitors...
266 KB (31,200 words) - 03:00, 15 August 2024
critical to the citric acid cycle. The GCS regulates glycine concentrations. HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are targets of the reduced form...
48 KB (4,958 words) - 01:02, 6 August 2024
Histone demethylase Histone acetylation and deacetylation Histone deacetylase HDAC1 Histone acetyltransferase DNA methylation: DNA methyltransferase Chromatin...
58 KB (6,787 words) - 20:17, 9 August 2024
enzymes are drugs that inhibit four specific histone-modifying enzymes: HDAC1, HDAC2, HDAC3, and HDAC8. Most of the animal research with HDAC inhibitors...
57 KB (7,191 words) - 06:17, 25 July 2024
certain genes (eg, cdk5) and repress others (eg, c-fos) where it recruits HDAC1 as a corepressor. ... Chronic exposure to psychostimulants increases glutamatergic...
26 KB (3,991 words) - 05:29, 10 July 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
66 KB (7,902 words) - 20:37, 3 August 2024
gastrulation, embryonic stem cells lacking HDAC1 acquired visible developmental defects. The continued culture of HDAC1 knockout embryonic stem cells showed...
28 KB (3,692 words) - 22:45, 3 December 2023
1) is located in the nuclear periphery as a result of interaction with HDAC1 and 2, which results in downregulation of insulin secretion. An increase...
121 KB (13,799 words) - 03:46, 30 July 2024
repressors proteins. pRb interacts with the histone deacetylases HDAC1 and HDAC3. pRb binds to HDAC1 in its pocket domain in a region that is independent to its...
79 KB (9,500 words) - 18:16, 10 June 2024
certain genes (eg, cdk5) and repress others (eg, c-fos) where it recruits HDAC1 as a corepressor. ... Chronic exposure to psychostimulants increases glutamatergic...
59 KB (20,590 words) - 17:30, 3 August 2024
certain genes (eg, cdk5) and repress others (eg, c-fos) where it recruits HDAC1 as a corepressor. ... Chronic exposure to psychostimulants increases glutamatergic...
58 KB (21,539 words) - 12:58, 7 August 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
56 KB (6,950 words) - 18:11, 14 August 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
25 KB (2,888 words) - 05:39, 22 March 2024
peroxisome proliferator-activated receptor-gamma-associated repression of HDAC1 at the C/ebp alpha gene promoter". The Journal of Biological Chemistry....
147 KB (16,686 words) - 08:00, 15 August 2024
ΔFosB binds to the c-fos gene and recruits several co-repressors, including HDAC1 (histone deacetylase 1) and SIRT 1 (sirtuin 1). ... The net result is c-fos...
103 KB (12,754 words) - 23:38, 15 July 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
36 KB (4,168 words) - 07:06, 10 August 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
10 KB (921 words) - 20:35, 10 March 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
23 KB (3,234 words) - 08:22, 7 February 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
55 KB (6,243 words) - 18:45, 2 August 2024
of reelin. One study indicated the upregulation of histone deacetylase HDAC1 in the hippocampi of patients. Histone deacetylases suppress gene promoters;...
140 KB (15,028 words) - 06:28, 5 August 2024
Propargylamine is used in the synthesis of: Etintidine [69539-53-3] 2-PAT HDAC1/MAO-B-IN-1 [2759855-37-1] Lauder, Kate; Toscani, Anita; Scalacci, Nicolò;...
2 KB (157 words) - 11:03, 25 June 2024