Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene. Histone acetylation and deacetylation, catalyzed by multisubunit...
50 KB (5,391 words) - 20:28, 22 May 2025
butyrate is an agonist of HCA2. It is also an HDAC inhibitor (specifically, HDAC1, HDAC2, HDAC3, and HDAC8), a drug that inhibits the function of histone...
65 KB (6,516 words) - 17:09, 2 July 2025
other Class I HDACs could compensate for the loss of HDAC1. This inability to recover from HDAC1 KO leads researchers to believe that there are both functional...
58 KB (7,027 words) - 19:10, 31 May 2025
in the absence of HDAC1. Their study also found a regulatory crosstalk between HDAC1 and HDAC2 and suggest a novel function for HDAC1 as a transcriptional...
31 KB (3,181 words) - 09:52, 22 May 2025
certain genes (eg, cdk5) and repress others (eg, c-fos) where it recruits HDAC1 as a corepressor. ... Chronic exposure to psychostimulants increases glutamatergic...
204 KB (23,557 words) - 14:01, 23 June 2025
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
26 KB (2,762 words) - 20:31, 19 June 2025
certain genes (eg, cdk5) and repress others (eg, c-fos) where it recruits HDAC1 as a corepressor. ... Chronic exposure to psychostimulants increases glutamatergic...
319 KB (34,051 words) - 02:48, 28 June 2025
enzymes are drugs that inhibit four specific histone-modifying enzymes: HDAC1, HDAC2, HDAC3, and HDAC8. Most of the animal research with HDAC inhibitors...
57 KB (7,191 words) - 12:09, 14 April 2025
itself inhibits class I histone deacetylase (HDAC) activity, specifically HDAC1, HDAC2, HDAC3, and butyrate can be used in determining histone deacetylene...
5 KB (436 words) - 13:46, 24 January 2024
suggests its regulation is more complex (evinced by the coexistence of HDAC1 and HDAC2 in three distinct protein complexes). Essentially, the mechanism...
41 KB (4,593 words) - 16:29, 18 June 2025
Histone demethylase Histone acetylation and deacetylation Histone deacetylase HDAC1 Histone acetyltransferase DNA methylation: DNA methyltransferase Chromatin...
58 KB (6,891 words) - 21:22, 4 July 2025
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
56 KB (6,826 words) - 21:11, 10 June 2025
maximal inhibitory concentrations (IC50) of 62 nM, 570 nM and 550 nM, against HDAC1, HDAC2 and HDAC3, respectively. It shows no activity against HDAC class...
11 KB (1,094 words) - 04:35, 19 March 2025
certain genes (eg, cdk5) and repress others (eg, c-fos) where it recruits HDAC1 as a corepressor. ... Chronic exposure to psychostimulants increases glutamatergic...
170 KB (16,585 words) - 22:58, 23 June 2025
DIM has action as a histone deacetylase inhibitor, specifically against HDAC1, HDAC2, and HDAC3. DIM is a metabolite of indole-3-carbinol. DIM was found...
5 KB (337 words) - 21:31, 18 May 2025
clinical trials for treatment of various cancers. Entinostat inhibits class I HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, respectively. Syndax pharmaceuticals...
5 KB (373 words) - 12:36, 23 September 2024
was also known as HBI-8000. It is a benzamide HDI and inhibits Class I HDAC1, HDAC2, HDAC3, as well as Class IIb HDAC10. Tucidinostat is approved by...
5 KB (283 words) - 06:19, 23 December 2024
1) is located in the nuclear periphery as a result of interaction with HDAC1 and 2, which results in downregulation of insulin secretion. An increase...
122 KB (13,834 words) - 20:50, 17 June 2025
certain genes (eg, cdk5) and repress others (eg, c-fos) where it recruits HDAC1 as a corepressor. ... Chronic exposure to psychostimulants increases glutamatergic...
26 KB (3,991 words) - 05:29, 10 July 2024
browsers. In particular, C22orf31 interacts with two histone deacetylases (HDAC1 and HDAC2) and the protein Lacritin (LACRT). These interactions were determined...
17 KB (1,227 words) - 00:40, 27 March 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
64 KB (7,256 words) - 00:17, 7 July 2025
gastrulation, embryonic stem cells lacking HDAC1 acquired visible developmental defects. The continued culture of HDAC1 knockout embryonic stem cells showed...
28 KB (3,692 words) - 00:32, 16 December 2024
repressors proteins. pRb interacts with the histone deacetylases HDAC1 and HDAC3. pRb binds to HDAC1 in its pocket domain in a region that is independent to its...
79 KB (9,501 words) - 00:55, 6 March 2025
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
57 KB (6,557 words) - 23:13, 7 July 2025
certain genes (eg, cdk5) and repress others (eg, c-fos) where it recruits HDAC1 as a corepressor. ... Chronic exposure to psychostimulants increases glutamatergic...
63 KB (23,109 words) - 01:23, 1 July 2025
certain genes (eg, cdk5) and repress others (eg, c-fos) where it recruits HDAC1 as a corepressor. ... Chronic exposure to psychostimulants increases glutamatergic...
65 KB (22,206 words) - 11:12, 4 July 2025
three MBD3 isoforms. MBD3 has been shown to interact with: AURKA, GATAD2B, HDAC1, MTA2, and MBD2. GRCh38: Ensembl release 89: ENSG00000071655 – Ensembl,...
12 KB (1,402 words) - 07:11, 20 May 2024
mechanisms Transcriptional ΔFosB c-Fos Cdk5 CREB GluR2 NF-κB Epigenetic G9a G9a-like protein HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HDAC10 SIRT1 SIRT2 ......
35 KB (7,125 words) - 16:15, 29 June 2025
peroxisome proliferator-activated receptor-gamma-associated repression of HDAC1 at the C/ebp alpha gene promoter". The Journal of Biological Chemistry....
147 KB (16,635 words) - 21:40, 7 May 2025
critical to the citric acid cycle. The GCS regulates glycine concentrations. HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are targets of the reduced form...
49 KB (4,977 words) - 09:25, 15 June 2025