Hepatocyte nuclear factor 4 alpha (redirect from HNF4A)
alpha (HNF4A) also known as NR2A1 (nuclear receptor subfamily 2, group A, member 1) is a nuclear receptor that in humans is encoded by the HNF4A gene....
18 KB (2,245 words) - 06:44, 25 July 2024
specific mutation (R76W) of HNF4A, a gene encoding a transcription factor, causes Fanconi syndrome in human. In the kidney, HNF4A is expressed in the proximal...
12 KB (1,203 words) - 05:48, 21 January 2024
consistent decrease in gliclazide clearance in randomly selected HNF1A-MODY and HNF4A-MODY patients. Its classification has been ambiguous, as literature uses...
18 KB (1,514 words) - 15:51, 7 June 2024
decrease in the clearance of sulfonylureas in randomly selected HNF1A-MODY and HNF4A-MODY patients. Chronic hyperglycemia due to any cause can eventually cause...
21 KB (2,261 words) - 20:16, 1 December 2023
hepatocyte nuclear factor 4 alpha (HNF4A) binding to a DR1 like cis element which then stimulate production. Competing with HNF4A at a third site on the promoter...
57 KB (4,584 words) - 22:43, 2 August 2024
subsection) Glycogenosis-like phenotype of congenital hyperinsulinism due to HNF4A mutation or MODY1 (maturity-onset diabetes of the young, type 1). This phenotype...
68 KB (6,092 words) - 20:34, 22 June 2024
are two paralogs of HNF4, HNF4α and HNF4γ, encoded by two separate genes HNF4A and HNF4G respectively. HNF4 was originally classified as an orphan receptor...
5 KB (536 words) - 19:30, 14 June 2023
MODY 1 or HNF4A-MODY is a form of maturity onset diabetes of the young. MODY 1 is due to a loss-of-function mutation in the HNF4A (MODY1) gene on chromosome...
3 KB (296 words) - 20:16, 1 December 2023
Homeodomain Known motif – High-throughput in vitro [368] GTTAATNATTAAY HNF4A ENSG00000101076 Nuclear receptor Known motif – High-throughput in vitro...
374 KB (81 words) - 02:10, 23 September 2023
A Hepatocyte nuclear factor-4 NR2A1 HNF4α Hepatocyte nuclear factor-4-α HNF4A fatty acids NR2A2 HNF4γ Hepatocyte nuclear factor-4-γ HNF4G B Retinoid X...
74 KB (6,675 words) - 18:09, 20 June 2024
ulcerative colitis identifies three new susceptibility loci, including the HNF4A region". Nature Genetics. 41 (12): 1330–1334. doi:10.1038/ng.483. ISSN 1061-4036...
11 KB (1,159 words) - 18:54, 19 April 2024
of genes over successive cell generations. HNF4A is a transcription regulator and it is unknown if HNF4A regulates C11orf73's expression or simply interacts...
19 KB (2,029 words) - 23:58, 28 November 2023
to high blood sugar can also be seen in those with changes in HNF1A and HNF4A genes. The natural history of HI goes beyond the problem of hypoglycemia...
90 KB (9,317 words) - 23:58, 3 August 2024
CDK5R1, CHUK, CTNND1, CTNNA1, EGFR, Emerin ESR1 FHL2, GSK3B, HER2/neu, HNF4A, IKK2, LEF1 including transgenically, MAGI1, MUC1, NR5A1, PCAF, PHF17, Plakoglobin...
107 KB (12,362 words) - 22:48, 10 July 2024
SLC30A8, JAZF1, HHEX, DGKB, CDKN2A, CDKN2B, KCNQ1, HNF1A, HNF1B MC4R, GIPR, HNF4A, MTNR1B, PPARG, ZBED3, SLC30A8, CDKAL1, GLIS3, GCK, GCKR, among others.KCNJ11...
19 KB (2,339 words) - 07:33, 22 June 2024
HGNC:5019 A6NHT5 7147 HNF1A HGNC:11621 P20823 7148 HNF1B HGNC:11630 P35680 7149 HNF4A HGNC:5024 P41235 7150 HNF4G HGNC:5026 Q14541 7151 HNMT HGNC:5028 P50135...
277 KB (17 words) - 15:46, 9 May 2024
JA, Potashkin JA (February 2015). "Network-based metaanalysis identifies HNF4A and PTBP1 as longitudinally dynamic biomarkers for Parkinson's disease"...
25 KB (2,906 words) - 02:06, 21 July 2024
Potashkin, Judith A. (2015-02-17). "Network-based metaanalysis identifies HNF4A and PTBP1 as longitudinally dynamic biomarkers for Parkinson's disease"...
9 KB (826 words) - 04:54, 27 September 2023
HNF1A, HNF-1A, HNF1, IDDM20, LFB1, MODY3, TCF-1, TCF1, HNF1 homeobox A, HNF4A, HNF1alpha External IDs OMIM: 142410; MGI: 98504; HomoloGene: 459; GeneCards:...
23 KB (2,599 words) - 05:46, 22 July 2024
2022-07-16. "QuickGO". www.ebi.ac.uk. Retrieved 2022-07-16. "Gene Set - hnf4a_16714383_e18dot5_liver_lof_mouse_gpl1261_gds1916". maayanlab.cloud. Retrieved...
18 KB (979 words) - 19:50, 12 May 2024
associated with this promoter and confirmed with a ChIP signal include HNF4A, CEBPB, ERG1, FOS1, ETS1, and E2F6. The binding sites for FOS, EGR1, and...
30 KB (3,105 words) - 03:44, 10 March 2024
nuclear factor 4 alpha (HNF4A) is also implicated in high lipid levels and metabolic syndromes. Cooperative effects of USF1 and HNF4A have been shown to regulate...
41 KB (4,538 words) - 20:56, 23 May 2024
hepatocyte nuclear factor 4 alpha Identifiers Symbol HNF4A Alt. symbols MODY, MODY1, NR2A1, TCF14 NCBI gene 3172 HGNC 5024 OMIM 600281 PDB 1M7W RefSeq...
8 KB (585 words) - 20:31, 30 May 2024
although severe cases have been reported. Individuals with FHI-HNF4A, caused by mutations in HNF4A, are typically born large for gestational age and have mild...
23 KB (3,043 words) - 00:32, 3 December 2023
factor binding sites associated with this promoter sequence, such as RB1, HNF4A, ETS1, and RBL2. C14orf119 is expressed in 203 organs. The c14orf119 gene...
26 KB (2,146 words) - 03:12, 22 May 2024
DYSF MNGIE without leukoencephalopathy; 603041; POLG MODY, type I; 125850; HNF4A MODY, type II; 125851; GCK MODY, type III; 600496; HNF1A MODY, type IV;...
234 KB (18,877 words) - 15:43, 9 May 2024
cytokinesis. One example is that ectopic expression of FOXA2 together with HNF4A drives transdifferentiation of fibroblasts to hepatocyte-like cells. Consistent...
12 KB (1,552 words) - 05:23, 3 June 2024
Suresh K. (2018). "DHQZ-17, a potent inhibitor of the transcription factor HNF4A, suppresses tumorigenicity of head and neck squamous cell carcinoma in vivo"...
6 KB (499 words) - 18:32, 23 April 2024