dehydrogenase [NADP], mitochondrial is an enzyme that in humans is encoded by the IDH2 gene. Isocitrate dehydrogenases are enzymes that catalyze the oxidative decarboxylation...
14 KB (1,844 words) - 17:35, 2 April 2024
inhibitor of isocitrate dehydrogenase-1 (IDH1) and isocitrate dehydrogenase-2 (IDH2), which are mutated in several forms of cancer. In a phase-III-trial, it...
3 KB (112 words) - 01:35, 6 May 2024
Glioma (section IDH1 and IDH2-mutated glioma)
and secondary high-grade gliomas. Wang et al. pointed out that IDH1 and IDH2 mutant cells produce an excess metabolic intermediate, 2-hydroxyglutarate...
59 KB (6,545 words) - 16:20, 12 July 2024
Mutations in the genes encoding for isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) occur in 10–20% of patients with myelodysplastic syndrome, and confer a...
59 KB (6,328 words) - 03:01, 1 July 2024
isocitrate dehydrogenase 2 (IDH2) gene, determined by an FDA-approved IDH2 companion diagnostic test. It is an inhibitor of IDH2. It was developed by Agios...
7 KB (417 words) - 16:49, 7 February 2024
Astrocytomas carry a mutation in IDH1 or IDH2, whereas this mutation is not present in glioblastoma. Thus, IDH1 and IDH2 mutations are a useful tool to distinguish...
80 KB (8,694 words) - 21:59, 7 July 2024
while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and...
33 KB (3,330 words) - 07:05, 3 April 2024
neoplasm. Cases in patients with Ollier disease has shown a link to IDH1, IDH2, and PTH1R gene mutations. Currently, there are no forms of treatment for...
29 KB (3,566 words) - 20:22, 3 December 2023
inhibiting isocitrate dehydrogenase-1 (IDH1) and isocitrate dehydrogenase-2 (IDH2), respectively. Ivosidenib is specific to acute myeloid leukemia (AML) and...
26 KB (3,001 words) - 22:09, 5 July 2024
isozymes, the other two being IDH2 and IDH3, and encoded by one of five isocitrate dehydrogenase genes, which are IDH1, IDH2, IDH3A, IDH3B, and IDH3G. IDH1...
28 KB (3,017 words) - 09:17, 11 December 2023
presence of IDH1 or IDH2 mutations and the codeletion of chromosome 1p and 19q arms. Interestingly, oligodendroglioma has a higher rate of IDH2 mutation than...
26 KB (2,938 words) - 02:35, 3 June 2024
mutations include in the DNA demethylase TET2 and the metabolic enzymes IDH1 and IDH2, which lead to the generation of a novel oncometabolite, D-2-hydroxyglutarate...
73 KB (7,249 words) - 23:44, 21 June 2024
Pollock, Robin; O'Donnell, Paul; Grigoriadis, Anita (Jul 2011). "IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal...
11 KB (1,043 words) - 08:46, 1 December 2023
presence or absence of a targeted protein via staining. Mutations in IDH1 and IDH2 genes are commonly found in low-grade gliomas Loss of both IDH genes combined...
95 KB (10,622 words) - 23:10, 8 July 2024
apparent. Maffucci syndrome is most commonly caused by mutations in the IDH1 or IDH2 gene. In Ollier's disease, isolated enchondromas are present without the...
6 KB (456 words) - 08:05, 27 December 2023
aciduria and a mixed type for both 2-hydroxyglutarates come from mutations in IDH2 gene and SLC25A1 gene, respectively. 2-hydroxyglutaric aciduria is an organic...
9 KB (830 words) - 04:22, 29 November 2023
2-hydroxyglutaric aciduria. Mutations in isocitrate dehydrogenase (IDH1 and IDH2), which frequently occur in glioma and AML, produce D-2-hydroxyglutarate...
7 KB (764 words) - 23:09, 6 March 2024
BCKDK BCKDHA BCKDHB (isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5) IDH2 IDH3A IDH3B IDH3G (tyrosine 3-monooxygenase) kinase (EC 2.7.11.6) STK4 Myosin-heavy-chain...
65 KB (7,147 words) - 05:41, 24 June 2024
mutations occur in approximately 6 to 10% of the patients with AML, and IDH2 mutations occur in approximately 9 to 13% of those with AML, with unknown...
18 KB (1,229 words) - 06:02, 10 March 2024
hedgehog signaling pathway inhibitors vismodegib, sonidegib -denib IDH1 and IDH2 inhibitors enasidenib, ivosidenib -lisib Phosphatidylinositol 3-kinase inhibitors...
26 KB (2,150 words) - 07:07, 12 June 2024
BCKDK BCKDHA BCKDHB (isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5) IDH2 IDH3A IDH3B IDH3G (tyrosine 3-monooxygenase) kinase (EC 2.7.11.6) STK4 Myosin-heavy-chain...
46 KB (5,492 words) - 03:05, 21 June 2024
BCKDK BCKDHA BCKDHB (isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5) IDH2 IDH3A IDH3B IDH3G (tyrosine 3-monooxygenase) kinase (EC 2.7.11.6) STK4 Myosin-heavy-chain...
35 KB (3,831 words) - 03:01, 8 July 2024
organisation (TUBG1, FLNA, PNKP, WDR62, PSMD3, HDAC6) and metabolism (PCK2, PFKL, IDH2, ACY1, and ADA). Aberrant SON-mediated RNA splicing results from the accumulation...
25 KB (2,954 words) - 11:16, 11 May 2024
diagnosis. The malignant TFH cells in AITL have mutations in their TET2, IDH2, and RHOA genes in 30–83% of cases whereas the malignant cells in PTCL, NOS...
139 KB (16,933 words) - 15:26, 5 July 2024
BCKDK BCKDHA BCKDHB (isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5) IDH2 IDH3A IDH3B IDH3G (tyrosine 3-monooxygenase) kinase (EC 2.7.11.6) STK4 Myosin-heavy-chain...
19 KB (2,170 words) - 06:41, 27 May 2024
BCKDK BCKDHA BCKDHB (isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5) IDH2 IDH3A IDH3B IDH3G (tyrosine 3-monooxygenase) kinase (EC 2.7.11.6) STK4 Myosin-heavy-chain...
27 KB (2,650 words) - 21:16, 19 March 2024
BCKDK BCKDHA BCKDHB (isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5) IDH2 IDH3A IDH3B IDH3G (tyrosine 3-monooxygenase) kinase (EC 2.7.11.6) STK4 Myosin-heavy-chain...
49 KB (5,394 words) - 05:41, 13 June 2024
BCKDK BCKDHA BCKDHB (isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5) IDH2 IDH3A IDH3B IDH3G (tyrosine 3-monooxygenase) kinase (EC 2.7.11.6) STK4 Myosin-heavy-chain...
33 KB (3,787 words) - 03:21, 17 June 2024
Importantly, TET2 is mutated in a mutually exclusive manner with WT1, IDH1, and IDH2. TET2 can be recruited by WT1, a sequence-specific zinc finger transcription...
25 KB (2,576 words) - 13:09, 21 January 2024
BCKDK BCKDHA BCKDHB (isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5) IDH2 IDH3A IDH3B IDH3G (tyrosine 3-monooxygenase) kinase (EC 2.7.11.6) STK4 Myosin-heavy-chain...
14 KB (1,385 words) - 10:32, 28 April 2024