Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that integrates (forms covalent links between) its genetic information into...

Integrase inhibitors (INIs) are a class of antiretroviral drug designed to block the action of integrase, a viral enzyme that inserts the viral genome...

version of its genome into the host cell DNA is called its "integrase". HIV-1 integrase catalyzes the “cut-and-paste” action of clipping the host DNA...

usually identical, but there are exceptions (e.g. attP and attB of λ integrase). Based on amino acid sequence homologies and mechanistic relatedness...

(backward). The new DNA is then incorporated into the host cell genome by an integrase enzyme, at which point the retroviral DNA is referred to as a provirus...

It contains bictegravir, a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor; emtricitabine, an HIV-1 nucleoside analog reverse...

to NNRTIs. Integrase inhibitors (also known as integrase nuclear strand transfer inhibitors or INSTIs) inhibit the viral enzyme integrase, which is responsible...

make development difficult. Integrase is a viral enzyme that integrates retroviral DNA into the host cell genome. Integrase inhibitors are a new class...

endowed with an RT (reverse-transcriptase) and an RNAse H domains, and an integrase (IN). Typically, LTR-retrotransposon mRNAs are produced by the host RNA...

specific recombination events. The enzyme (38 kDa) is a member of the integrase family of site specific recombinase and it is known to catalyse the site...

cell nucleus and integrated into the cellular DNA by a virally encoded integrase and host co-factors. Once integrated, the virus may become latent, allowing...

(insufflation), a method of administrating some medications and vaccines Integrase, a retroviral enzyme In (album), by the Outsiders, 1967 In (Korean name)...

treatment of HIV/AIDS. each pill contains 50 mg dolutegravir, as the salt, an integrase strand transfer inhibitor (INSTI), and 300 mg lamivudine, a nucleoside...

viral RNA. Another target is integrase, which integrate the synthesized DNA into the host cell genome. Examples of integrase inhibitors include raltegravir...

resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) and integrase strand transfer inhibitors. Cabotegravir/rilpivirine must not be combined...

and architecture. The founding member of the YR family is the lambda integrase, encoded by bacteriophage λ, enabling the integration of phage DNA into...

breastfeeding is safe. Dolutegravir is an HIV integrase strand transfer inhibitor which blocks the functioning of HIV integrase which is needed for viral replication...

Dolutegravir/lamivudine/tenofovir Combination of Dolutegravir Integrase strand transfer inhibitor Lamivudine Nucleoside reverse transcriptase inhibitor...

nucleus and integrated into the cellular DNA by a virally encoded enzyme, integrase, and host co-factors. Once integrated, the virus may become latent, allowing...

longer available) Attachment inhibitors fostemsavir (brand name Rukobia) Integrase strand transfer inhibitors (INSTIs): dolutegravir (brand name Tivicay)...

non-catalytic site integrase inhibitor (NCINI). It inhibits HIV replication via binding to a conserved allosteric pocket of the HIV integrase enzyme. This makes...

The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications...

analogue RTI Docosanol Herpes Simplex Entry inhibitor Dolutegravir HIV Integrase inhibitor Doravirine (Pifeltro) HIV NNRTI Edoxudine Herpes Simplex Thymidine...

early stages of genome replication, and include reverse transcriptase and integrase. Reverse transcriptase is the virally encoded RNA-dependent DNA polymerase...

integron platform by site-specific recombination reactions mediated by the integrase. Integrons were initially discovered on conjugative plasmids through their...

(cDNA). The cDNA is integrated into the host cell's genome by the enzyme integrase, which causes the host cell to generate viral proteins that reassemble...

use in children, and agreed to negotiate a license for dolutegravir, an integrase inhibitor then in clinical development. In 2014, this license was extended...

Viruses can also contain enzymes for infecting cells, such as the HIV integrase and reverse transcriptase, or for viral release from cells, like the influenza...

breastfeeding is safe. Raltegravir is an HIV integrase strand transfer inhibitor which blocks the functioning of HIV integrase which is needed for viral replication...

Bictegravir (INN; BIC, formerly known as GS-9883) is a second-generation integrase inhibitor (INSTI) class that was structurally derived from an earlier...