Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling...
28 KB (3,166 words) - 19:57, 8 August 2024
the kinase activity of the first. The four JAK family members are: Janus kinase 1 (JAK1) Janus kinase 2 (JAK2) Janus kinase 3 (JAK3) Tyrosine kinase 2 (TYK2)...
9 KB (974 words) - 14:46, 22 June 2024
A Janus kinase inhibitor, also known as JAK inhibitor or jakinib, is a type of immune modulating medication, which inhibits the activity of one or more...
35 KB (2,984 words) - 10:45, 30 August 2024
Janus kinase 3 inhibitors, also called JAK3 inhibitors, are a new class of immunomodulatory agents that inhibit Janus kinase 3. They are used for the treatment...
17 KB (2,126 words) - 15:12, 16 June 2024
them to escape their tumor and metastasize to other parts of the body. Janus kinase 1 has been shown to interact with: ELP2, GNB2L1 IL6ST, Grb2, IL2RB, IRS1...
21 KB (2,423 words) - 03:55, 27 January 2024
Tyrosine-protein kinase JAK3 is a tyrosine kinase enzyme that in humans is encoded by the JAK3 gene. Janus kinase 3 is a tyrosine kinase that belongs to the janus family...
41 KB (5,166 words) - 16:45, 28 January 2023
abnormalities in megakaryocytes; and The presence of a mutation in the Janus kinase 2 (JAK2) gene. Patients usually have a very low level of erythropoietin...
24 KB (2,684 words) - 10:59, 5 June 2024
interest-free bank Janus kinase, a family of intracellular, nonreceptor tyrosine kinases including Janus kinase 1 (JAK1) Janus kinase 2 (JAK2) Janus kinase 3 (JAK3)...
1 KB (165 words) - 21:34, 5 June 2024
Pacritinib (category Non-receptor tyrosine kinase inhibitors)
myelofibrosis. It is a macrocyclic protein kinase inhibitor. It mainly inhibits Janus kinase 2 (JAK2) and Fms-like tyrosine kinase 3\CD135 (FLT3). Common side effects...
7 KB (315 words) - 01:07, 18 May 2024
Receptor binding leads to recruitment of Janus kinase 2 and Tyrosine kinase 2 kinases. Janus kinase 2 and Tyrosine kinase 2 transduce the signal and phosphorylate...
20 KB (2,192 words) - 23:02, 27 November 2023
Fedratinib (category Protein kinase inhibitors)
capsules that are taken by mouth. It is a semi-selective inhibitor of Janus kinase 2 (JAK-2). It was approved by the FDA on 16 August 2019. Myelofibrosis is...
10 KB (691 words) - 05:40, 18 July 2024
with hydroxyurea (a cytoreducing agent) or anagrelide (Agrylin). In Janus kinase 2 positive disorders, ruxolitinib (Jakafi) can be effective.[citation...
11 KB (1,066 words) - 01:55, 17 March 2024
Deuruxolitinib (category Janus kinase inhibitors)
It is a Janus kinase inhibitor selective for JAK1 and JAK2. Although the relative effectiveness of deuruxolitinib and another Janus kinase inhibitor—baricitinib—for...
9 KB (457 words) - 08:58, 6 August 2024
Examples of the P-type ATPase include Na+/K+-ATPase that is regulated by Janus Kinase-2 as well as Ca2+ ATPase which exhibits sensitivity to ADP and ATP concentrations...
17 KB (2,039 words) - 00:13, 6 August 2024
polycythemia vera or primary thrombocytosis), most commonly due to a Janus kinase 2 (JAK2) gene mutation. Oral contraceptive use or pregnancy are other...
11 KB (1,223 words) - 17:12, 22 July 2024
has been found on chromosome 22. YES1 has been shown to interact with Janus kinase 2, CTNND1, RPL10 and Occludin. GRCh38: Ensembl release 89: ENSG00000176105...
8 KB (1,028 words) - 12:23, 11 May 2024
Lestaurtinib (category Non-receptor tyrosine kinase inhibitors)
It is an inhibitor of the kinases fms-like tyrosine kinase 3 (FLT3), Janus kinase 2 (JAK2), tropomyosin receptor kinase (trk) A (TrkA), TrkB and TrkC...
15 KB (1,584 words) - 18:53, 14 May 2024
Jak 2 can refer to: Jak II, the second installment in the Jak and Daxter video game series JAK2, member of the Janus kinase family This disambiguation...
188 bytes (62 words) - 10:40, 2 April 2022
with Janus family kinases (JAKs) to affect intracellular signaling. Cytokines including interleukins, interferons and hemopoietins activate the Janus kinases...
25 KB (2,850 words) - 23:00, 12 November 2023
receptor has been shown to interact with: CRKL, Erythropoietin, Grb2, Janus kinase 2, LYN, PIK3R1, PTPN6, SOCS2, SOCS3, and STAT5A. GRCh38: Ensembl release...
28 KB (3,409 words) - 18:05, 8 June 2024
Janus kinase 2, a tyrosine kinase that initiates the JAK-STAT pathway. Activation also results in the activation of mitogen-activated protein kinases...
56 KB (5,820 words) - 00:14, 19 May 2024
activity against cells expressing JAK2(V617F), a mutated form of the janus kinase 2 (JAK2) enzyme that is implicated in the pathophysiology of many myeloproliferative...
16 KB (1,288 words) - 15:34, 8 July 2024
CHZ868 (category Janus kinase inhibitors)
CHZ868 is a drug which acts as a Janus kinase inhibitor selective for the JAK2 subtype. It was one of the first Janus kinase inhibitors developed, originally...
4 KB (271 words) - 20:23, 22 June 2024
arginine methyltransferase 5 has been shown to interact with: CLNS1A, Janus kinase 2, SNRPD3, SUPT5H, MEP50, RIOK1, COPR5. PRMT5 has been shown to interact...
13 KB (1,410 words) - 04:58, 17 June 2024
Li J, Feltzer RE, Dawson KL, Hudson EA, Clark BJ (December 2003). "Janus kinase 2 and calcium are required for angiotensin II-dependent activation of...
4 KB (592 words) - 10:03, 16 August 2023
TEC (gene) (category Tyrosine kinases)
Tyrosine-protein kinase Tec is a tyrosine kinase that in humans is encoded by the TEC gene. Tec kinase is expressed in hematopoietic, liver, and kidney...
20 KB (2,433 words) - 23:10, 27 March 2024
receptor, Glycoprotein 130, Insulin-like growth factor 1 receptor, Janus kinase 2, PTPN11, and RAS p21 protein activator 1. There is some evidence that...
16 KB (1,922 words) - 21:02, 8 November 2023
Growth hormone receptor has been shown to interact with SGTA, PTPN11, Janus kinase 2, Suppressor of cytokine signaling 1 and CISH. The GHR gene is used in...
18 KB (1,925 words) - 16:27, 31 March 2024
STAT5B has been shown to interact with: Glucocorticoid receptor, Janus kinase 1, Janus kinase 2, and PTPN11. STAT5 GRCh38: Ensembl release 89: ENSG00000173757...
5 KB (526 words) - 12:21, 14 January 2024