Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling...

the kinase activity of the first. The four JAK family members are: Janus kinase 1 (JAK1) Janus kinase 2 (JAK2) Janus kinase 3 (JAK3) Tyrosine kinase 2 (TYK2)...

A Janus kinase inhibitor, also known as JAK inhibitor or jakinib, is a type of immune modulating medication, which inhibits the activity of one or more...

Janus kinase 3 inhibitors, also called JAK3 inhibitors, are a new class of immunomodulatory agents that inhibit Janus kinase 3. They are used for the treatment...

them to escape their tumor and metastasize to other parts of the body. Janus kinase 1 has been shown to interact with: ELP2, GNB2L1 IL6ST, Grb2, IL2RB, IRS1...

Tyrosine-protein kinase JAK3 is a tyrosine kinase enzyme that in humans is encoded by the JAK3 gene. Janus kinase 3 is a tyrosine kinase that belongs to the janus family...

abnormalities in megakaryocytes; and The presence of a mutation in the Janus kinase 2 (JAK2) gene. Patients usually have a very low level of erythropoietin...

interest-free bank Janus kinase, a family of intracellular, nonreceptor tyrosine kinases including Janus kinase 1 (JAK1) Janus kinase 2 (JAK2) Janus kinase 3 (JAK3)...

myelofibrosis. It is a macrocyclic protein kinase inhibitor. It mainly inhibits Janus kinase 2 (JAK2) and Fms-like tyrosine kinase 3\CD135 (FLT3). Common side effects...

Receptor binding leads to recruitment of Janus kinase 2 and Tyrosine kinase 2 kinases. Janus kinase 2 and Tyrosine kinase 2 transduce the signal and phosphorylate...

capsules that are taken by mouth. It is a semi-selective inhibitor of Janus kinase 2 (JAK-2). It was approved by the FDA on 16 August 2019. Myelofibrosis is...

with hydroxyurea (a cytoreducing agent) or anagrelide (Agrylin). In Janus kinase 2 positive disorders, ruxolitinib (Jakafi) can be effective.[citation...

It is a Janus kinase inhibitor selective for JAK1 and JAK2. Although the relative effectiveness of deuruxolitinib and another Janus kinase inhibitor—baricitinib—for...

Examples of the P-type ATPase include Na+/K+-ATPase that is regulated by Janus Kinase-2 as well as Ca2+ ATPase which exhibits sensitivity to ADP and ATP concentrations...

polycythemia vera or primary thrombocytosis), most commonly due to a Janus kinase 2 (JAK2) gene mutation. Oral contraceptive use or pregnancy are other...

has been found on chromosome 22. YES1 has been shown to interact with Janus kinase 2, CTNND1, RPL10 and Occludin. GRCh38: Ensembl release 89: ENSG00000176105...

It is an inhibitor of the kinases fms-like tyrosine kinase 3 (FLT3), Janus kinase 2 (JAK2), tropomyosin receptor kinase (trk) A (TrkA), TrkB and TrkC...

Jak 2 can refer to: Jak II, the second installment in the Jak and Daxter video game series JAK2, member of the Janus kinase family This disambiguation...

Insulin receptor, Insulin-like growth factor 1 receptor, IRS1, Janus kinase 1, Janus kinase 2, LAIR1, LRP1, PDGFRB, PI3K → Akt PLCG2, PTK2B, Ras SLAMF1, SOCS3...

with Janus family kinases (JAKs) to affect intracellular signaling. Cytokines including interleukins, interferons and hemopoietins activate the Janus kinases...

receptor has been shown to interact with: CRKL, Erythropoietin, Grb2, Janus kinase 2, LYN, PIK3R1, PTPN6, SOCS2, SOCS3, and STAT5A. GRCh38: Ensembl release...

Janus kinase 2, a tyrosine kinase that initiates the JAK-STAT pathway. Activation also results in the activation of mitogen-activated protein kinases...

activity against cells expressing JAK2(V617F), a mutated form of the janus kinase 2 (JAK2) enzyme that is implicated in the pathophysiology of many myeloproliferative...

CHZ868 is a drug which acts as a Janus kinase inhibitor selective for the JAK2 subtype. It was one of the first Janus kinase inhibitors developed, originally...

arginine methyltransferase 5 has been shown to interact with: CLNS1A, Janus kinase 2, SNRPD3, SUPT5H, MEP50, RIOK1, COPR5. PRMT5 has been shown to interact...

Li J, Feltzer RE, Dawson KL, Hudson EA, Clark BJ (December 2003). "Janus kinase 2 and calcium are required for angiotensin II-dependent activation of...

Tyrosine-protein kinase Tec is a tyrosine kinase that in humans is encoded by the TEC gene. Tec kinase is expressed in hematopoietic, liver, and kidney...

receptor, Glycoprotein 130, Insulin-like growth factor 1 receptor, Janus kinase 2, PTPN11, and RAS p21 protein activator 1. There is some evidence that...

Growth hormone receptor has been shown to interact with SGTA, PTPN11, Janus kinase 2, Suppressor of cytokine signaling 1 and CISH. The GHR gene is used in...

STAT5B has been shown to interact with: Glucocorticoid receptor, Janus kinase 1, Janus kinase 2, and PTPN11. STAT5 GRCh38: Ensembl release 89: ENSG00000173757...