• Thumbnail for L-selectin
    L-selectin, also known as CD62L, is a cell adhesion molecule found on the cell surface of leukocytes, and the blastocyst. It is coded for in the human...
    22 KB (2,808 words) - 11:18, 7 August 2024
  • Thumbnail for Selectin
    subsets of selectins: E-selectin (in endothelial cells) L-selectin (in leukocytes) P-selectin (in platelets and endothelial cells) L-selectin is the smallest...
    19 KB (2,424 words) - 13:08, 20 November 2023
  • Thumbnail for P-selectin glycoprotein ligand-1
    platelet), which is one of a family of selectins that includes E-selectin (endothelial) and L-selectin (leukocyte). Selectins are part of the broader family of...
    11 KB (1,456 words) - 10:43, 5 January 2024
  • Thumbnail for P-selectin
    P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. P-selectin functions as a cell adhesion molecule (CAM) on the...
    20 KB (2,584 words) - 05:42, 5 September 2024
  • Thumbnail for Leukocyte extravasation
    E-selectin follows shortly after P-selectin synthesis, induced by cytokines such as IL-1 and TNFα. E-selectins bind PSGL-1 and ESL-1. L-selectins: L-selectins...
    27 KB (3,333 words) - 21:09, 14 August 2024
  • Thumbnail for E-selectin
    E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell...
    31 KB (3,758 words) - 14:52, 7 September 2024
  • are E-selectin (endothelial), L-selectin (leukocyte), and P-selectin (platelet). The best-characterized ligand for the three selectins is P-selectin glycoprotein...
    16 KB (1,905 words) - 07:17, 26 April 2024
  • Thumbnail for CD34
    enter lymph nodes. It is expressed on lymph node endothelia, whereas the L-selectin to which it binds is on the T cell. Conversely, under other circumstances...
    27 KB (3,084 words) - 01:44, 21 December 2023
  • Thumbnail for Implantation (embryology)
    carbohydrate moieties on its extracellular domain that are ligands of L-selectin, a cell adhesion molecule on the surface of trophoblast cells. An in vitro...
    51 KB (5,914 words) - 21:10, 16 August 2024
  • Thumbnail for CD44
    sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). (see below) Transcripts...
    26 KB (2,890 words) - 05:01, 17 August 2024
  • process by interacting with L-selectin, which is present on the surface of lymphocytes. The adhesion molecule L-selectin binds to sulfated carbohydrate...
    3 KB (346 words) - 22:09, 26 February 2024
  • addressins, which are specific adhesion molecules that attach to the L-selectins on lymphocytes and anchor them to the HEV wall in preparation for crossing...
    10 KB (1,336 words) - 17:21, 17 August 2024
  • Thumbnail for Cell junction
    P-selectin and E-selectin. L-selectin deals with lymphocytes, monocytes and neutrophils, P-selectin deals with platelets and endothelium and E-selectin deals only...
    20 KB (2,248 words) - 10:19, 16 July 2024
  • Thumbnail for Addressin
    preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into...
    15 KB (1,785 words) - 06:26, 21 August 2024
  • for the receptor L-selectin allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues. GLYCAM1 binds to L-selectin by presenting one...
    2 KB (258 words) - 03:16, 13 October 2020
  • Thumbnail for Carcinoembryonic antigen
    sialofucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination...
    21 KB (2,301 words) - 02:50, 9 September 2024
  • function. Sulfatide also acts as an L-selectin and P-selectin ligand, but it does not act as an E- selectin ligand. Selectins are adhesion molecules that facilitate...
    45 KB (5,620 words) - 18:46, 13 September 2024
  • (TCM cells) express CD45RO, C-C chemokine receptor type 7 (CCR7), and L-selectin (CD62L). Central memory T cells also have intermediate to high expression...
    32 KB (3,781 words) - 12:49, 26 April 2024
  • Naive T cells are commonly characterized by the surface expression of L-selectin (CD62L) and C-C Chemokine receptor type 7 (CCR7); the absence of the activation...
    9 KB (1,147 words) - 07:16, 18 July 2023
  • the selectin family, mucin-like family, and the Ig superfamily. Naive lymphocyte extravasation into Peyer’s patches is often mediated by L-selectin and...
    7 KB (893 words) - 12:51, 4 December 2022
  • Thumbnail for T cell
    (TCM cells) express CD45RO, C-C chemokine receptor type 7 (CCR7), and L-selectin (CD62L). Central memory T cells also have intermediate to high expression...
    71 KB (9,026 words) - 12:33, 26 April 2024
  • of other important catch bonds in the 2000s, including those between L-selectin and PSGL-1 or endoglycan, FimH and mannose, myosin and actin, platelet...
    43 KB (5,492 words) - 21:33, 22 April 2024
  • glycoforms of podocalyxin expressed by colon carcinoma cells possess L-selectin and E-selectin binding activity, and the affinity of the binding may be pivotal...
    10 KB (1,139 words) - 04:26, 4 June 2024
  • roll along the vessel. An example of this is the interaction between L-selectin and the PNAD (peripheral node addressin) ligand. Arrest of the 'rolling'...
    20 KB (2,733 words) - 11:03, 18 August 2023
  • Thumbnail for Sialyl-Lewis X
    bind to L-selectin. For the binding to L-selectin to occur, sialyl-LewisX must undergo sulfation. For sialyl-LewisX to bind to P-selectin, an O-linked...
    18 KB (1,846 words) - 22:55, 14 June 2024
  • Thumbnail for T helper cell
    effector memory T cells lack the C-C chemokine receptor type 7 (CCR7) and L-selectin (CD62L) receptors, which prevents them from trafficking to the lymph nodes...
    54 KB (6,597 words) - 14:51, 21 July 2024
  • Thumbnail for PODXL2
    SD (2003). "Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x"...
    1 KB (212 words) - 22:19, 3 March 2023
  • Ublituximab CD23 Gomiliximab Lumiliximab CD40 Teneliximab Toralizumab CD62L/L-selectin Aselizumab CD80 Galiximab CD147/Basigin Gavilimomab CD154 Frexalimab Ruplizumab...
    7 KB (299 words) - 13:45, 27 April 2024
  • Thumbnail for List of therapeutic monoclonal antibodies
    4 January 2023. Retrieved 3 January 2023. Wilde, Michelle I.; Goa, Karen L. (1 May 1996). "Muromonab CD3". Drugs. 51 (5): 865–894. doi:10.2165/00003495-199651050-00010...
    136 KB (4,020 words) - 07:14, 15 August 2024
  • Thumbnail for Heparan sulfate
    XVIII, a Basement Membrane Heparan Sulfate Proteoglycan, Interacts with L-selectin and Monocyte Chemoattractant Protein-1". Journal of Biological Chemistry...
    36 KB (4,151 words) - 06:37, 27 May 2024