Leucine-rich repeat kinase 2 (LRRK2), also known as dardarin (from the Basque word "dardara" which means trembling) and PARK8 (from early identified association...

increased by mutations in the genes encoding leucine-rich repeat kinase 2 (LRRK2), Parkinson's disease-associated deglycase (PARK7), PRKN, PINK1, or SNCA...

and deafness, DFNB1 (connexin 26) Parkinson's disease (G2019S/LRRK2 mutation; The LRRK2 mutation on the main haplotype, shared by Ashkenazi Jews, North...

include SNCA, LRRK2, and VPS35 for autosomal dominant inheritance, and PRKN, PINK1, and DJ1 for autosomal recessive inheritance. LRRK2 is estimated to...

kinase 2 (LRRK2) plays a role in the phosphorylation of Rab GTPases which consequently regulates vesicular trafficking. Dysfunction of the LRRK2 due to a...

three-dimensional picture. Villa determined the structure of the LRRK2 protein. Mutations in LRRK2 are the most frequent cause of Parkinson's disease. The protein...

Mutations in genes such as α-synuclein (SNCA), leucine-rich repeat kinase 2 (LRRK2), glucocerebrosidase (GBA), and tau protein (MAPT) can also cause hereditary...

early onset Parkinson's disease (PD). The neuropathology seen is similar to LRRK2-associated PD. None of the genes affected in individuals with 22q11.2DS...

PMC 2824165. PMID 18940696. Kumar A, Cookson MR (June 2011). "Role of LRRK2 kinase dysfunction in Parkinson disease". Expert Reviews in Molecular Medicine...

inhibit the antimicrobial activity of Paneth cells. ATG16L1, IRGM, and LRRK2 are proteins involved in selective autophagy, the mechanism by which Paneth...

Small-scale transport, promoter for tumor development RAB27 Extracellular vesicles, endosome RAB29 Recruits LRRK2 to TGN RAB39A Binds Caspase-1 in inflammasome...

disease and in clinical presentation of symptoms of genetic forms of PD. LRRK2: LRRK2 is expressed by innate and adaptive immune cells as well as by enteric...

at the Francis Crick Institute. Gandhi's publications include: A common LRRK2 mutation in idiopathic Parkinson's disease Mechanism of Oxidative Stress...

treatments. Five genes are specific risk to migraine with aura, PALMD, ABO, LRRK2, CACNA1A and PRRT2, and 13 genes are specific to migraine without aura....

role of LRRK2 and synaptojanin 1 signalling pathway in neurodegeneration. Yue’s investigation demonstrated that vitamin B12 modulates LRRK2 kinase activity...

LRRIQ1: encoding protein Leucine-rich repeats and IQ motif containing 1 LRRK2: leucine-rich repeat kinase 2 MBOAT5: encoding enzyme Lysophospholipid acyltransferase...

Valina L Dawson (2014). "Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease". Cell. 157 (2): 472–485. doi:10...

In the gene that encodes LRRK2 (leucine-rich repeat kinase 2), a susceptibility locus for IBD was found. The kinase LRRK2 is an inhibitor for the NFATc2...

Van Goor  United States Thomas Gasser  Germany "for identifying GBA1 and LRRK2 as risk genes for Parkinson's disease, implicating autophagy and lysosomal...

Parkinson's disease. Rarely, mutations in SNCA, the gene for alpha-synuclein, or LRRK2, a gene for a kinase enzyme, can cause any of DLB, Alzheimer's disease,...

LRRK2 increase its kinase activity and that inhibition of LRRK2 kinase activity is protective in models of Parkinson's disease. The increase in LRRK2...

Di Paolo G, McCabe BD, et al. (February 2013). "RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk". Neuron...

gene mutations, PINK1 gene mutations and the most common mutations in the LRRK2 gene were identified in Japanese and European families. The pathological...

LRRK2 can exhibit both Lewy body pathology and tau pathology, but it is also unclear as to its relationship. On the other hand, results from LRRK2 mutation...

KATNB1, KIAA1336, KIF21A, KIF21B, KM-PA-2, KEAP1, LLGL1, LLGL2, LRBA, LRRK1, LRRK2, LRWD1, LYST, MAPKBP1, MED16, MORG1, NBEA, NBEAL1, NEDD1, NLE1, NSMAF, NUP37...

Pharmaceuticals Ellen Sidransky (born 1955)  United States "for identifying GBA1 and LRRK2 as risk genes for Parkinson's disease, implicating autophagy and lysosomal...

later he led the group that was the first to identify mutations in the LRRK2 gene as a cause of familial Parkinson's disease, as well as the more common...

DNQKFVRLKD IIFDV NCL and LRRK2 was experimentally determined to interacted with C12orf29. NCL physically interacted with C12orf29, and LRRK2 was associated with...

early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2 R1441G) transgenic mouse". Neuroscience Letters. 549: 57–62. doi:10.1016/j...

A6PVS8 8952 LRRIQ4 HGNC:34298 A6NIV6 8953 LRRK1 HGNC:18608 Q38SD2 8954 LRRK2 HGNC:18618 Q5S007 8955 LRRN1 HGNC:20980 Q6UXK5 8956 LRRN2 HGNC:16914 O75325...