Micro ribonucleic acid (microRNA, miRNA, µRNA) are small, single-stranded, non-coding RNA molecules containing 21–23 nucleotides. Found in plants, animals...
148 KB (16,818 words) - 21:15, 29 October 2024
sequence microRNAs, also called miRNAs. miRNA-seq differs from other forms of RNA-seq in that input material is often enriched for small RNAs. miRNA-seq allows...
49 KB (5,200 words) - 07:39, 12 December 2023
Gary Ruvkun (section miRNA lin-4)
which lin-4, the first microRNA (miRNA) discovered by Victor Ambros, regulates the translation of target messenger RNAs via imperfect base-pairing to...
33 KB (3,190 words) - 02:12, 24 October 2024
RNA viruses. MicroRNAs (miRNAs) are small RNAs that typically are partially complementary to sequences in metazoan messenger RNAs. Binding of a miRNA...
50 KB (6,021 words) - 19:21, 15 October 2024
ribonucleic acid (RNA) molecules, microRNA (miRNA) and small interfering RNA (siRNA), are central to components to the RNAi pathway. Once mRNA is degraded,...
140 KB (15,409 words) - 08:23, 28 October 2024
Gene expression (redirect from RNA expression)
nucleotidyl transferase. In the case of micro RNA (miRNA), miRNAs are first transcribed as primary transcripts or pri-miRNA with a cap and poly-A tail and processed...
102 KB (11,438 words) - 17:14, 31 October 2024
levels. Using single-stranded RNA (ssRNA) fragments, such as microRNA (miRNA), or double-stranded small interfering RNA (siRNA), the complex functions as...
36 KB (3,844 words) - 04:25, 29 October 2024
example is RNA interference (RNAi), in which endogenously expressed microRNA (miRNA) or exogenously derived small interfering RNA (siRNA) induces the...
47 KB (5,449 words) - 12:35, 27 October 2024
interfering RNA (siRNA) and micro RNA (miRNA) to prevent mRNA translation and/or degrade mRNA. However, RNA aptamers are short, single stranded RNA molecules...
77 KB (8,887 words) - 03:21, 29 October 2024
Those may then be sequenced to identify the miRNA present, as well as analysing expression levels of a given miRNA by counting the number of times it is present...
17 KB (2,127 words) - 11:27, 13 August 2023
MicroRNA (miRNA) biosensors are analytical devices that involve interactions between the target miRNA strands and recognition element on a detection platform...
64 KB (7,163 words) - 19:55, 26 June 2024
multiple miRNA targets alter the number of unbound miRNAs and lead to observable changes in miRNA activity - i.e., the abundance of other miRNA targets...
25 KB (3,201 words) - 19:34, 3 November 2024
micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in...
67 KB (7,178 words) - 04:34, 29 October 2024
targets miR-7 (hence the name CiRS-7 – Circular RNA Sponge for miR-7). It has over 60 miR-7 binding sites, far more than any known linear miRNA sponge...
55 KB (6,557 words) - 21:55, 24 August 2024
municipality in Slovenia Mount Mirna, a hill in Slovenia Mirna (name), a female name microRNA, abbreviated as miRNA USS Mirna (SP-1214), a United States Navy...
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Atherosclerosis (section miRNA)
aorta. MicroRNAs (miRNAs) have complementary sequences in the 3' UTR and 5' UTR of target mRNAs of protein-coding genes, and cause mRNA cleavage or repression...
100 KB (11,111 words) - 09:26, 26 October 2024
typically 20–24 base pairs in length, similar to microRNA (miRNA), and operating within the RNA interference (RNAi) pathway. It interferes with the expression...
56 KB (6,837 words) - 04:51, 29 October 2024
transfer RNA (tRNA), microRNA (miRNA), small interfering RNA (siRNA), small nucleolar RNA (snoRNAs), Piwi-interacting RNA (piRNA), tRNA-derived small RNA (tsRNA)...
65 KB (7,617 words) - 15:36, 3 November 2024
that circulating miRNA may be utilized as novel biomarkers, hence show promising evidence to be utilized in disease diagnostics. MiRNAs are formed from...
23 KB (2,586 words) - 20:09, 27 March 2024
of miRNA activity begins with the synthesis of pri-miRNA in the nucleus by RNA polymerase II which is then converted into pre-miRNA. This pre-miRNA exits...
59 KB (7,834 words) - 20:36, 29 September 2024
Dicer (category RNA interference)
double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short double-stranded RNA fragments called small interfering RNA and microRNA, respectively...
26 KB (3,267 words) - 20:14, 27 September 2024
Oncomir (category RNA)
is a microRNA (miRNA) that is associated with cancer. MicroRNAs are short RNA molecules about 22 nucleotides in length. Essentially, miRNAs specifically...
19 KB (1,974 words) - 04:49, 17 June 2024
identification. FISH can also be used to detect and localize specific RNA targets (mRNA, lncRNA and miRNA)[citation needed] in cells, circulating tumor cells, and...
40 KB (4,617 words) - 07:21, 2 November 2024
The C19MC miRNA cluster is a microRNA cluster consisting of 46 genes. These 46 genes encode 59 mature miRNAs. The C19MC miRNA cluster is only found in...
2 KB (200 words) - 00:18, 28 September 2022
mRNA transcripts, RNA-Seq can look at different populations of RNA to include total RNA, small RNA, such as miRNA, tRNA, and ribosomal profiling. RNA-Seq...
103 KB (11,110 words) - 05:04, 28 October 2024
ncRNAs function by binding to other RNAs. For example, miRNAs regulate protein coding gene expression by binding to 3' UTRs, small nucleolar RNAs guide...
151 KB (8,470 words) - 10:25, 2 November 2024
Epigenetics (section RNA methylation)
far, in 2013, about 2000 miRNAs have been discovered in humans and these can be found online in a miRNA database. Each miRNA expressed in a cell may target...
160 KB (18,271 words) - 15:20, 28 October 2024
cholesterol, lipid rafts, and ceramides), and nucleic acids (such as DNA, mRNA, and miRNA). Since the size of exosomes is limited by that of the parent MVB, exosomes...
69 KB (7,390 words) - 21:58, 1 November 2024
Piwi (section Role in RNA interference)
germ-line determination is due to their capacity to interact with miRNAs. Components of the miRNA pathway appear to be present in pole plasm and to play a key...
17 KB (1,948 words) - 22:39, 1 July 2024
Rheumatoid arthritis (section MicroRNAs)
anti-TNFa/DMRADs combination therapy. For example, miRNA-16-5p, miRNA-23-3p, miRNA125b-5p, miRNA-126-3p, miRNA-146a-5p, miRNA-223-3p. Curious fact is that only responder...
149 KB (16,151 words) - 17:55, 8 November 2024