Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress. The process...

activation. Parkin plays a crucial role in mitophagy and clearance of reactive oxygen species. Mitophagy is the elimination of damaged mitochondria in...

autophagy. In the selective autophagy is the autophagy of organelles; mitophagy, lipophagy, pexophagy, chlorophagy, ribophagy and others. Macroautophagy...

collaborations. Gottlieb leads ongoing research focused on autophagy, mitophagy and biogenesis, with particular attention to the molecular basis of myocardial...

uncoupling agent in cell and molecular biology, particularly in the study of mitophagy, where it was integral in discovering the role of the Parkinson's disease-associated...

Mitochondrial metabolic rates Mitochondrial permeability transition pore Mitophagy Nebenkern Oncocyte Oncocytoma Paternal mtDNA transmission Plastid Submitochondrial...

contribution to inflammaging is a decline in effective autophagy and mitophagy capacity. This is an essential process for cellular housekeeping that...

required to clear damaged mitochondria from the cell (a process called mitophagy). BRCA1 (also known as FANCS) interacts with the ribosomal DNA (rDNA)...

anticancer therapy. It is known to suppress tumors and plays a role in mitophagy and apoptosis. AMBRA1 can be found in the cytoskeleton and mitochondria...

Sathyamoorthy B, Noursadeghi M, et al. (January 2021). "NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial...

selectively degrade damaged cytosolic organelles such as mitochondria (mitophagy). However, when the cell is starved or stressed, autophagosomes can also...

014. PMID 30459101. Kirienko NV, Ausubel FM, Ruvkun G (February 2015). "Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa"...

mitochondria that has been rendered nonfunctional in a process known as mitophagy. However, mutations in the Parkin and pink1 genes have been associated...

deal with malfunctioning mitochondria in neurons, a process known as mitophagy. Patients with Parkinson's disease typically show mutations on two proteins...

differentiation and maturation of erythrocytes and lymphocytes by the process of mitophagy with the help of its regulator BNIP3. Using a gene knockout technique...

destruction. He also investigated molecular mechanisms of autophagy and mitophagy. He received the NIH Director’s Award in 1992, 2011, and 2015. For 2021...

with low LAMP2 protein level and lysosome number (both important for mitophagy: the degradation of defective mitochondria pathway), could be implicated...

Sathyamoorthy B, Noursadeghi M, et al. (January 2021). "NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial...

properly. UPRmt causes the sirtuin SIRT3 to activate antioxidant enzymes and mitophagy. Mitochondrial electron transport chain mutations that extend the life...

Springer W, Kahle PJ (March 2011). "Regulation of PINK1-Parkin-mediated mitophagy". Autophagy. 7 (3): 266–78. doi:10.4161/auto.7.3.14348. PMID 21187721...

increase of the autophagy of mitochondria, a process called mitophagy. An increase in mitophagy triggers the development and progression of cancer. MUC-1...

WFS2. In some cases, mutation of the gene can lead to premature aging, mitophagy and mitochondrial dysfunction. In studies using mice, WFS2 caused a decrease...

having this been shown to drive autophagy of mitochondria (also known as mitophagy). PINK1 is a protein normally transported into the mitochondrion, but...

to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells". Nature Cell Biology. 15 (10): 1197–205. doi:10.1038/NCB2837...

FIS1 protein does not play a role in fission but instead is involved in mitophagy. In human cells, there are four adaptor proteins for Drp1, these being...

of both mitochondrial synthesis (biogenesis), as well as degradation (mitophagy) in muscle. In his research, he also employs multi-disciplinary approaches...

cell response against viral infection in lupus patients by suppressing mitophagy". Science Advances. 8 (24): eabo4271. Bibcode:2022SciA....8O4271C. doi:10...

123.3191.309. PMID 13298683. Mahla, RS; et al. (2021). "NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial...

causing ROS-producing mitochondria to undergo selective lysosome-dependent mitophagy during nutrient starvation conditions. Under severe stress/pathologic...

imbalance, leading to excess mitochondrial clearance from dendrites by mitophagy. LRRK2 is also a substrate for chaperone-mediated autophagy. Mutations...