Myostatin (also known as growth differentiation factor 8, abbreviated GDF8) is a protein that in humans is encoded by the MSTN gene. Myostatin is a myokine...
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Myostatin inhibitors are a class of drugs that work by blocking the effects of myostatin, which inhibits muscle growth. In animal models and limited human...
11 KB (1,195 words) - 00:18, 21 June 2024
Myostatin-related muscle hypertrophy is a rare genetic condition characterized by reduced body fat and increased skeletal muscle size. Affected individuals...
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natural mutation in the myostatin gene which codes for the protein, myostatin ("myo" meaning muscle and "statin" meaning stop). Myostatin is a protein that...
11 KB (1,226 words) - 11:43, 4 November 2024
known mutations that limits and reduces the activity of the myostatin protein. Normally, myostatin limits the number of muscle fibers present at birth, and...
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Sarcopenic obesity (section Myostatin Inhibitors)
injury/inflammation in response to stress) are increased in sarcopenic obesity. Myostatin is also increased. In the fat, lipotoxicity and chronic inflammation are...
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identified a natural variant of the myostatin gene found in Limousins which has a significant influence on them. The myostatin gene is found in all mammals and...
86 KB (10,454 words) - 09:39, 24 October 2024
Piedmontese cattle carry a unique gene mutation identified as an inactive myostatin allele that causes hypertrophic muscle growth, or double muscling. Purebred...
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amount of myostatin portray deficiency in muscle development and increase of fat; on the other hand, smaller than normal amounts of myostatin greatly increase...
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PMID 23995658. Lee SJ, Gharbi A, Shin JE, Jung ID, Park YM (March 2021). "Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis"...
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naturally occurring gene identified as the myostatin allele mutation, or inactive myostatin gene. Myostatin prohibits muscle growth whereas an inactive...
17 KB (1,804 words) - 04:55, 10 June 2023
second leading cause of mortality in Whippets. A 2007 study identified a myostatin mutation particular to Whippets that is significantly associated with...
27 KB (2,793 words) - 20:34, 27 October 2024
Stamulumab (category Myostatin inhibitors)
Stamulumab (MYO-029) is an experimental myostatin inhibiting drug developed by Wyeth Pharmaceuticals for the treatment of muscular dystrophy (MD). Stamulumab...
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Follistatin (category Myostatin inhibitors)
its role in regulation of muscle growth in mice, as an antagonist to myostatin (also known as GDF-8, a TGF superfamily member) which inhibits excessive...
19 KB (2,169 words) - 14:40, 2 September 2024
Gene doping (section Myostatin)
small interfering RNA. Myostatin is a protein responsible for inhibiting muscle differentiation and growth. Removing the myostatin gene or otherwise limiting...
32 KB (3,911 words) - 03:05, 15 September 2024
Apitegromab (category Myostatin inhibitors)
precursor to myostatin, which limits the size of skeletal muscle tissue, as well as inactive myostatin. It does not bind to active myostatin, activin A...
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; McPherron, Alexandra C. (October 2011). "Expression and Function of Myostatin in Obesity, Diabetes, and Exercise Adaptation". Medicine and Science in...
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binds to myostatin, it lowers the amount of myostatin that can bind to the native receptor in the membrane (ActRIIB), preventing myostatin from delivering...
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(Drm) LTBP1 Noggin TGIF Thrombospondin 1 (THBS1) Tomoregulin 1 Antibodies: Stamulumab (against myostatin) TRC105 (against endoglin) Others: Endoglin...
67 KB (8,184 words) - 20:48, 31 October 2024
to myostatin, a negative regulator of muscle growth, both structurally and phylogenetically. Though GDF11 is 90% structurally similar to myostatin, GDF11's...
34 KB (3,979 words) - 20:36, 23 June 2024
monoclonal antibody that blocks the activation of the skeletal muscle protein myostatin, thereby promoting muscle tissue growth. As of 2021, the molecule showed...
90 KB (10,010 words) - 03:07, 11 November 2024
Davis' law Follistatin Lean body mass Muscle atrophy Muscle dystrophy Myostatin Pseudoathletic appearance Pseudohypertrophy Baechle TR, Earle RW, eds...
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may refer to: Kocher–Debré–Semelaigne syndrome Adrenogenital syndrome Myostatin mutation resulting in hypertrophy and increased strength This disambiguation...
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receptors regulate muscle growth. Myostatin, a TGF-beta superfamily member, is a negative regulator of muscle growth. Myostatin binds to ACVR2B and to a lesser...
6 KB (583 words) - 15:40, 29 March 2023
et al. (2016). "Testosterone and trenbolone enanthate increase mature myostatin protein expression despite increasing skeletal muscle hypertrophy and...
18 KB (1,722 words) - 21:22, 28 August 2024
(Drm) LTBP1 Noggin TGIF Thrombospondin 1 (THBS1) Tomoregulin 1 Antibodies: Stamulumab (against myostatin) TRC105 (against endoglin) Others: Endoglin...
13 KB (1,405 words) - 18:36, 28 October 2024
follicle-stimulating hormone; it also has many other systemic effects. Myocytes use myostatin to tell each other to inhibit myogenesis. Melanocyte-inhibiting factor...
6 KB (652 words) - 09:36, 4 July 2023
the use of superhuman strength in fiction. Berserker Furor Teutonicus Myostatin Physical strength Hysterical strength Kumar, Rajesh (2010-09-01). "Competing...
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Eddie Hall (category People with Myostatin-related muscle hypertrophy)
Edward Stephen Hall (born 15 January 1988) is a British media personality and a retired strongman. He is best known for his world-record setting 500 kg...
33 KB (2,883 words) - 21:43, 7 November 2024