TTX-resistant VGSC: Nav1.5, Nav1.8 and Nav1.9. Nav1.8 and Nav1.9 are both expressed in nociceptors (damage-sensing neurons). Nav1.7, Nav1.8 and Nav1.9 are found...

G's (facelift) 2010–2014 Voxy G's (facelift) NAV1 (Indonesia) 2013 Toyota NAV1 V (Indonesia) 2013 NAV1 V (Indonesia) The third-generation Noah and Voxy...

Sodium voltage-gated channel alpha subunit 9 (also Nav1.7) is a sodium ion channel that in humans is encoded by the SCN9A gene. It is usually expressed...

Neuron navigator 1 is a protein that in humans is encoded by the NAV1 gene. This gene belongs to the neuron navigator family and is expressed predominantly...

(NaV1.1, NaV1.2, NaV1.3, NaV1.6), neuronal channels (NaV1.7, NaV1.8 and NaV1.9), skeletal muscle channels (NaV1.4) and the cardiac sodium channel NaV1...

characterized in Nav1.1–Nav1.5. Among these channels, Nav1.1–Nav1.3 and Nav1.5 display depolarized voltage-dependence of activation, while activation in Nav1.4 remains...

non-electric fishes the channels Nav1.4a and Nav1.4b are present in the muscles, while in Gymnotiformes and Mormyriformes Nav1.4a has disappeared in the muscles...

subunit alpha is a protein that in humans is encoded by the SCN4A gene. The Nav1.4 voltage-gated sodium channel is encoded by the SCN4A gene. Mutations in...

expression of NaV1.8 in the former. Consequently, expression of NaV1.8 channels in sympathetic neurons also expressing L858H mutant NaV1.7 results in neurons...

or Nav1.9 is a voltage-gated sodium ion channel protein which is encoded by the SCN11A gene on chromosome 3 in humans. Like Nav1.7 and Nav1.8, Nav1.9 plays...

II (Nav1.2), and III (Nav1.3). There are also several distinct sodium channel alpha subunit isoforms in skeletal and cardiac muscle (Nav1.4 and Nav1.5,...

channel protein type 8 subunit alpha also known as Nav1.6 is a membrane protein encoded by the SCN8A gene. Nav1.6 is one sodium channel isoform and is the primary...

channels, in particular, voltage-gated sodium channels Nav1.3, Nav1.5, Nav1.6, Nav1.7, and Nav1.8, voltage-gated potassium channels Kv7.2/ Kv7.3, Kv7.1...

all cases, this disorder can be in the voltage-gated sodium channel SCN9A (Nav1.7). Patients with such mutations are congenitally insensitive to pain and...

the alpha subunit for the NaV1.7 sodium channel and the SCN10A gene instructs the production of the alpha subunit for the NaV1.8 sodium channel. Sodium...

of 59 nM) NDRI (norepinephrine and dopamine reuptake inhibitor) Nav1.7, Nav1.8, and Nav1.9 sodium channel blocker HERG potassium channel blocker George...

CNS, Nav1.2 is initially expressed at all forming nodes of Ranvier. Upon maturation, nodal Nav1.2 is down-regulated and replaced by Nav1.6. Nav1.2 is...

selective Nav1.7 and Nav1.8 blocker. Funapide (TV-45070, XEN402) – selective Nav1.7 and Nav1.8 blocker. GDC-0276 (RG-7893) – selective Nav1.7 blocker...

700 nM). CBG is a voltage-gated sodium channel (VGSC) blocker (Nav1.1, Nav1.2, Nav1.5, and Nav1.7) and voltage-dependent calcium channel (VDCC) blocker. Inhibition...

non-opioid, small-molecule analgesic that works as a selective inhibitor of Nav1.8-dependent pain-signaling pathways in the peripheral nervous system. It...

anemone toxins act on voltage-gated sodium channels (NaV1.1, NaV1.2, NaV1.4, NaV1.5, NaV1.6, NaV1.7) and depending on their affinity to a specific isoform...

NaV1.7 in dorsal root ganglion (DRG) neurons. It is a NaV1.7 agonist. Makatoxin-3 has little to no effect on NaV1.1, NaV1.3, NaV1.6, NaV1.8, and NaV1...

It targets TTX-S channels (NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) with the highest affinity against NaV1.7 channels. NaV1.7 channels are expressed in...

contain sodium channel protein type 2 subunit alpha are sometimes called Nav1.2 channels. Voltage-gated sodium channels are transmembrane glycoprotein...

analgesic properties, probably owing to its strong inhibitory effects on Nav1.7 channels. Ssm6a is purified from the venom of the Chinese red-headed centipede...

erythromelalgia, as well as dental pain. It acts as a small-molecule Nav1.7 and Nav1.8 voltage-gated sodium channel blocker. Funapide is being evaluated...

DSP-2230 is a selective small-molecule Nav1.7 and Nav1.8 voltage-gated sodium channel blocker which is under development by Dainippon Sumitomo Pharma...

originally claimed to be a selective central Nav1.3 blocker, but was subsequently redefined as a selective peripheral Nav1.7 blocker.[citation needed] Following...

Borges-Monroy R, Partlow JN, et al. (September 2018). "Sodium Channel SCN3A (NaV1.3) Regulation of Human Cerebral Cortical Folding and Oral Motor Development"...

inactivation of different voltage-gated sodium channels, including Nav1.1 and Nav1.2, thus prolonging action potentials. ATX-II is the main component...