Exo-α-sialidase (EC 3.2.1.18, sialidase, neuraminidase; systematic name acetylneuraminyl hydrolase) is a glycoside hydrolase that cleaves the glycosidic...
16 KB (1,568 words) - 17:03, 31 May 2024
Viral neuraminidase is a type of neuraminidase found on the surface of influenza viruses that enables the virus to be released from the host cell. Neuraminidases...
11 KB (1,059 words) - 09:11, 30 January 2024
Hemagglutinin-neuraminidase refers to a single viral protein that has both hemagglutinin and (endo) neuraminidase EC 3.2.1.18 activity. This is in contrast...
4 KB (366 words) - 21:21, 6 August 2023
Neuraminidase inhibitors (NAIs) are a class of drugs which block the neuraminidase enzyme. They are a commonly used antiviral drug type against influenza...
10 KB (1,048 words) - 22:22, 8 November 2023
Zanamivir (category Neuraminidase inhibitors)
prevent influenza caused by influenza A and influenza B viruses. It is a neuraminidase inhibitor and was developed by the Australian biotech firm Biota Holdings...
19 KB (1,930 words) - 11:22, 8 March 2024
Bacterial neuraminidase is type of neuraminidase and a virulence factor for many bacteria including Bacteroides fragilis and Pseudomonas aeruginosa. Its...
2 KB (97 words) - 02:46, 1 May 2024
Oseltamivir (category Neuraminidase inhibitors)
Oseltamivir was approved for medical use in the US in 1999. It was the first neuraminidase inhibitor available by mouth. It is on the World Health Organization's...
63 KB (5,829 words) - 20:59, 29 June 2024
Galactosialidosis (redirect from Neuraminidase beta-galactosidase deficiency)
Galactosialidosis, also known as neuraminidase deficiency with beta-galactosidase deficiency, is a genetic lysosomal storage disease. It is caused by...
15 KB (1,712 words) - 18:54, 2 February 2024
IAV subtype that has a type-1 hemagglutinin (H) protein and a type-1 neuraminidase (N) protein. Almost all possible combinations of H (1 thru 16) and N...
52 KB (5,397 words) - 17:11, 10 July 2024
Neuraminidase inhibitors inhibit enzymatic activity of the enzyme neuraminidase (sialidase). These type of inhibitors have been introduced as anti-influenza...
30 KB (4,066 words) - 17:50, 28 January 2023
major glycoprotein (HA) spike is interposed irregularly by clusters of neuraminidase (NA) spikes, with a ratio of HA to NA of about 10 to 1. The viral envelope...
39 KB (4,234 words) - 22:25, 30 May 2024
attachment and entry. Parainfluenza hemagglutinin-neuraminidase: a type of hemagglutinin-neuraminidase produced by parainfluenza, which is closely associated...
14 KB (1,581 words) - 01:43, 10 July 2024
Mumps virus (redirect from Mumps hemagglutinin-neuraminidase)
protein, small hydrophobic (SH) transmembrane protein, hemagglutinin-neuraminidase (HN), and the large (L) protein, which combines with the P protein to...
21 KB (2,850 words) - 02:50, 3 December 2023
Parainfluenza hemagglutinin-neuraminidase is a type of hemagglutinin-neuraminidase produced by parainfluenza. Murrell M, Porotto M, Weber T, Greengard...
1 KB (109 words) - 18:10, 29 April 2022
orthomyxovirus that contains the glycoproteins hemagglutinin (H) and neuraminidase (N), antigens whose subtypes are used to classify the strains of the...
52 KB (5,143 words) - 14:52, 26 June 2024
combination of the antigenic viral proteins haemagglutinin (H) and neuraminidase (N) in the viral envelope; for example, "H1N1" designates an IAV subtype...
110 KB (12,801 words) - 20:12, 10 July 2024
results from changes occurring in neuraminidase and hemagglutinin proteins on the viral surface. Currently, neuraminidase inhibitors (NAIs) are the most...
55 KB (6,733 words) - 06:43, 13 June 2024
Sialidosis (redirect from Alpha-neuraminidase deficiency)
disease that results from a deficiency of the enzyme alpha-N -acetyl neuraminidase (sialidase). The lack of this enzyme results in an abnormal accumulation...
5 KB (539 words) - 10:23, 11 May 2024
for Disease Control and Prevention (CDC) guidelines recommend only neuraminidase inhibitors for influenza treatment and prophylaxis.[medical citation...
47 KB (4,670 words) - 03:35, 23 April 2024
two proteins on the surface of the viral envelope; hemagglutinin and neuraminidase. These are the major antigens of the virus against which neutralizing...
64 KB (7,183 words) - 21:10, 9 July 2024
Sialidase-1, is a mammalian lysosomal neuraminidase enzyme which in humans is encoded by the NEU1 gene. The protein SIALIDASE-1 encoded by the NEU-1 gene...
10 KB (1,234 words) - 03:35, 6 May 2024
and routine use for treating pneumonia is not supported by evidence. Neuraminidase inhibitors may be used to treat viral pneumonia caused by influenza...
120 KB (12,708 words) - 18:58, 21 April 2024
determined by the Hemagglutinin (HA) and Neuraminidase (NA) proteins present on its surface. Neuraminidase (NA) has 11 known subtypes, hence influenza...
27 KB (3,152 words) - 20:26, 12 May 2024
protein membrane contains the glycoproteins hemagglutinin (HA) and neuraminidase (NA) which are used by the virus to enter a host cell, and subsequently...
27 KB (2,791 words) - 14:44, 14 June 2024
hemagglutinin and neuraminidase. The hemagglutinin is responsible for binding and entry into host epithelial cells while the neuraminidase is involved in...
11 KB (1,395 words) - 17:50, 19 October 2023
(NP), phosphoprotein (P) and the large protein (L). The hemagglutinin–neuraminidase (HN) is involved with viral attachment and thus hemadsorption and hemagglutination...
28 KB (2,836 words) - 08:37, 8 June 2024
filamentous. Its 500 or so surface projections are made of hemagglutinin and neuraminidase. The influenza B virus genome is 14,548 nucleotides long and consists...
28 KB (3,046 words) - 20:50, 30 June 2024
II. His interest in the influenza receptor led him to discover the neuraminidase that is secreted by Vibrio cholerae, which later provided the foundation...
81 KB (10,547 words) - 21:28, 10 June 2024
transcriptase, or for viral release from cells, like the influenza virus neuraminidase. An important function of enzymes is in the digestive systems of animals...
96 KB (9,819 words) - 05:08, 8 July 2024
Peramivir (category Neuraminidase inhibitors)
influenza. Peramivir is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new...
12 KB (1,046 words) - 05:43, 13 April 2024