• Thumbnail for Nonsense-mediated decay
    Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that exists in all eukaryotes. Its main function is to reduce errors in gene expression by...
    23 KB (2,900 words) - 08:39, 17 August 2024
  • Thumbnail for Messenger RNA
    subject to surveillance by nonsense-mediated decay (NMD), which checks for the presence of premature stop codons (nonsense codons) in the message. These...
    49 KB (5,922 words) - 14:24, 18 August 2024
  • nonsense-mediated mRNA decay pathway (NMD); the nonstop mediated mRNA decay pathways (NSD); and the no-go mediated mRNA decay pathway (NGD). Nonsense-mediated...
    29 KB (3,394 words) - 21:28, 16 March 2024
  • Thumbnail for Eukaryotic translation termination factor 1
    recognition in translation, termination of translation, and nonsense mediated mRNA decay via the SURF complex. All cells need to make proteins through...
    43 KB (5,515 words) - 12:51, 1 August 2024
  • Thumbnail for Exon junction complex
    splicing, but along with Y14, it also takes part in the process of nonsense-mediated decay in eukaryotes. SRm160 is another coactivator that has been proposed...
    21 KB (2,530 words) - 04:47, 23 August 2024
  • Thumbnail for SR protein
    alternative pre-mRNA splicing, mRNA export, genome stabilization, nonsense-mediated decay, and translation. SR proteins alternatively splice pre-mRNA by...
    27 KB (3,445 words) - 17:16, 7 August 2024
  • Thumbnail for Nuclear cap-binding protein complex
    ways that it does this quality control is through nonsense-mediated decay. Nonsense-mediated decay is when faulty mRNA's that have stop codons too early...
    12 KB (1,489 words) - 15:46, 30 May 2024
  • Thumbnail for UPF1
    between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa...
    11 KB (1,390 words) - 09:32, 17 August 2024
  • Thumbnail for UPF3A
    between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa...
    9 KB (1,135 words) - 09:27, 17 August 2024
  • types of situations with nonsense mutations occur a lot less frequently than the deleterious outcomes. Nonsense-mediated mRNA decay Despite an expected tendency...
    25 KB (2,870 words) - 22:43, 9 March 2024
  • Thumbnail for UPF3B
    between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa...
    9 KB (1,176 words) - 23:46, 4 September 2022
  • Thumbnail for Non-stop decay
    In contrast to nonsense-mediated decay (NMD), polypeptides do not release from the ribosome, and thus, NSD seems to involve mRNA decay factors distinct...
    7 KB (1,014 words) - 04:04, 10 June 2023
  • Thumbnail for UPF2
    between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa...
    11 KB (1,292 words) - 02:17, 24 December 2023
  • Thumbnail for Messenger RNA decapping
    A number of specific decay pathways exist that recognize aberrant messages and promote their decapping. Nonsense mediated decay recognizes premature stop...
    4 KB (452 words) - 16:19, 29 June 2024
  • partially completed polypeptide or degradation of the mRNA by nonsense-mediated decay. The redundancy of tRNA genes makes sure that such mutation would...
    5 KB (627 words) - 10:53, 15 September 2022
  • errors explains why most splice variants are rapidly degraded by nonsense-mediated decay. The presence of sloppy binding sites within genes causes splicing...
    47 KB (5,839 words) - 23:00, 11 July 2024
  • Thumbnail for Dopamine receptor D3
    encode different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). Alpha-synuclein (α-Syn) aggregation via Lewy bodies inclusion...
    28 KB (3,177 words) - 08:06, 12 July 2024
  • Deaths, a humanitarian aid organization Non-metropolitan district Nonsense mediated decay, a mechanism of messenger RNA surveillance Norsk Medisinaldepot...
    536 bytes (86 words) - 07:58, 22 August 2024
  • Thumbnail for SMG7
    nonsense mediated mRNA decay factor (C. elegans)". Yang L, Kraft VA, Pfeiffer S, Merl-Pham J, Bao X, An Y, et al. (June 2020). "Nonsense-mediated decay...
    5 KB (588 words) - 20:13, 8 April 2022
  • pseudogene because all associated transcripts are candidates for nonsense-mediated decay (NMD). Rahim MM, Tu MM, Mahmoud AB, Wight A, Abou-Samra E, Lima...
    4 KB (336 words) - 23:31, 6 September 2021
  • Thumbnail for EIF4A3
    eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay". Nature. 427 (6976): 753–7. Bibcode:2004Natur.427..753P. doi:10...
    11 KB (1,125 words) - 01:19, 29 March 2024
  • Thumbnail for DCP2
    of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Molecular and Cellular Biology. 22 (23): 8114–8121. doi:10.1128/MCB...
    7 KB (799 words) - 21:38, 2 December 2023
  • Thumbnail for PABPC1
    high translational activity. PABPC1 is also associated with nonsense-mediated mRNA decay (NMD). PABPC1 binds to the poly(A) tail and interact with eIF4G...
    14 KB (1,663 words) - 02:04, 8 April 2024
  • Thumbnail for P2RX7
    encode different isoforms have been identified although some fit nonsense-mediated decay criteria. The receptor is found in the central and peripheral nervous...
    32 KB (3,366 words) - 23:28, 16 July 2024
  • Thumbnail for DCP1A
    decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature...
    8 KB (874 words) - 20:18, 27 July 2022
  • Thumbnail for NeuN
    Cytoplasmic Isoforms Differentially Regulate Alternative Splicing and Nonsense-Mediated Decay of Rbfox2". PLOS ONE. 6 (6): e21585. Bibcode:2011PLoSO...621585D...
    8 KB (982 words) - 19:03, 25 June 2024
  • Thumbnail for Insertion (genetics)
    carrying the frameshift mutation may also be degraded through Nonsense-mediated decay during translation, thus not resulting in any protein product....
    8 KB (936 words) - 18:17, 7 September 2024
  • length by increasing euchromatin formation. On the other hand, nonsense-mediated decay factor enrichment at telomeres may exist to prevent TERRA inhibition...
    3 KB (312 words) - 22:54, 9 April 2024
  • upstream ORFs and transcripts that are predicted to be candidates for nonsense-mediated decay. Curation occurs continuously, and any of the collaborating centers...
    28 KB (2,912 words) - 17:28, 5 March 2024
  • nucleus, where its function is unknown. It may have a role in nonsense-mediated decay. eIF4G stands for eukaryotic initiation factor 4 gamma (typically...
    8 KB (1,074 words) - 01:25, 9 January 2023