• A nuclear localization signal or sequence (NLS) is an amino acid sequence that 'tags' a protein for import into the cell nucleus by nuclear transport...
    15 KB (2,036 words) - 22:45, 26 August 2024
  • nucleus. It does so by binding to specific recognition sequences, called nuclear localization sequences (NLS). Importin has two subunits, importin α and importin...
    18 KB (2,026 words) - 20:24, 2 April 2024
  • Look up localization, L10n, or localize in Wiktionary, the free dictionary. Localization or localisation may refer to: Localization of function, locating...
    4 KB (507 words) - 05:16, 15 December 2024
  • Thumbnail for Dishevelled
    the cytoplasm and nucleus, via a conserved nuclear export sequence (NES) and a nuclear localization sequence (NLS), both necessary for proper functioning...
    12 KB (1,387 words) - 18:30, 20 July 2024
  • Thumbnail for Nucleoplasm
    Nucleoplasm (redirect from Nuclear sap)
    genes (6784 genes) have been found to localize to the nucleoplasm via targeting by a nuclear localization sequence (NLS). Cytosolic proteins, known as importins...
    16 KB (1,925 words) - 22:37, 21 March 2024
  • Thumbnail for NeuN
    adds a C-terminal PY type nuclear localization sequence, which presumably explains why NeuN/Fox-3 protein can be both nuclear and, in some cell types,...
    8 KB (982 words) - 19:03, 25 June 2024
  • Thumbnail for Fibroblast growth factor 1
    FGF1 can also function intracellularly. The protein has a nuclear localization sequence (NLS) but the route that FGF1 takes to get to the nucleus is...
    20 KB (2,311 words) - 22:01, 16 July 2024
  • Thumbnail for G2 phase
    accomplished via removal of nuclear localization sequence (NLS)-obscuring phosphates and phosphorylation of the nuclear export signal. It is thought...
    22 KB (2,818 words) - 07:39, 3 June 2024
  • Thumbnail for SV40 large T antigen
    protein to study nuclear localization signals (NLSs). It is imported into the nucleus by its interaction with importin α. The NLS sequence is PKKKRKV. SV40...
    12 KB (1,413 words) - 20:11, 3 January 2023
  • Thumbnail for Lamin
    Lamin (redirect from Nuclear lamins)
    the type of lamin. However, all C-terminal domains contain a nuclear localization sequence (NLS). Similar to other IF proteins, lamins self-assemble into...
    18 KB (2,198 words) - 21:16, 18 July 2024
  • dominant role in recognition of the DR sequences in the transposon. The RED subdomain overlaps with the nuclear localization signal, but its function remains...
    30 KB (2,762 words) - 12:46, 17 November 2024
  • Thumbnail for Major capsid protein VP1
    icosahedral assembly. The C-terminus also contains a basic nuclear localization sequence,: 316  while the N-terminus - which is oriented toward the center...
    11 KB (1,059 words) - 00:01, 3 December 2023
  • bipartite nuclear localization sequence which is the major signal for protein entry into the nucleus. Dingwall C, Laskey RA. Nuclear targeting sequences—a consensus...
    2 KB (266 words) - 01:39, 5 January 2024
  • Thumbnail for Guanosine diphosphate
    referred to as the Nuclear Import process, cytosolic proteins like alpha and beta importins would bind the nuclear localization sequence that is located...
    7 KB (713 words) - 21:59, 16 December 2024
  • Thumbnail for Heterogeneous ribonucleoprotein particle
    mRNA in the cytoplasm. However, hnRNPs also have their own nuclear localization sequences (NLS) and are therefore found mainly in the nucleus. Though...
    17 KB (2,057 words) - 19:45, 8 December 2024
  • Thumbnail for Importin subunit alpha-1
    "Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences". Science. 268 (5213): 1049–53. Bibcode:1995Sci...268.1049W...
    13 KB (1,632 words) - 12:07, 22 December 2023
  • Thumbnail for Archaea
    known life forms List of Archaea genera List of sequenced archaeal genomes Nuclear localization sequence Stirrup protein domain The Surprising Archaea (book)...
    159 KB (16,791 words) - 11:16, 21 December 2024
  • Thumbnail for IκBα
    the NF-κB transcription factor. IκBα inhibits NF-κB by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an...
    13 KB (1,526 words) - 18:27, 5 February 2024
  • Thumbnail for Rel homology domain
    family. The dimerization subdomain is immediately followed by a nuclear localization sequence that also comprises the site for inhibitory interactions with...
    3 KB (307 words) - 19:27, 12 May 2024
  • Thumbnail for Transportin 1
    This protein is a karyopherin which interacts with nuclear localization sequence to target nuclear proteins to the nucleus. The classical karyopherin...
    12 KB (1,531 words) - 13:22, 23 December 2023
  • referred to as signal sequence, targeting signal, localization signal, localization sequence, transit peptide, leader sequence or leader peptide) is a...
    15 KB (1,775 words) - 19:46, 18 December 2024
  • releasing the catalytic subunit. The catalytic subunit has a nuclear localization sequence which prompts it to go into the nucleus and phosphorylate other...
    41 KB (5,252 words) - 05:01, 2 November 2024
  • Thumbnail for Nuclear lamina
    extended rod domain (42 amino acid longer), that they all carry a nuclear localization signal (NLS) at their C-terminus and that they display typical tertiary...
    15 KB (1,862 words) - 21:56, 28 November 2024
  • Thumbnail for TNPO2
    Süel KE, Louis TH, Zhang Z, Chook YM (August 2006). "Rules for nuclear localization sequence recognition by karyopherin beta 2". Cell. 126 (3): 543–58. doi:10...
    4 KB (527 words) - 01:51, 17 April 2022
  • the cytoplasm through the nuclear pore complex using nuclear transport. It has the opposite effect of a nuclear localization signal, which targets a protein...
    10 KB (1,282 words) - 02:21, 23 October 2023
  • Thumbnail for Cyclin B3
    differs from the expected sequence: rather than containing a leucine it has a phenylalanine. The nuclear localization sequence (NLS) of chicken cyclin B3...
    16 KB (1,890 words) - 00:28, 21 December 2024
  • karyopherin proteins. Importin α is known to bind to the nuclear localization signal (NLS) sequence of nucleus targeted proteins. After this recognition,...
    14 KB (1,829 words) - 00:49, 26 June 2023
  • Thumbnail for Chromosome 5 open reading frame 47
    is predicted to be localized in the nucleus. A stretch of five positively charged lysines, indicating a nuclear localization sequence, can be found at positions...
    17 KB (1,178 words) - 16:55, 4 October 2023
  • Thumbnail for Agnoprotein
    acid sequence, a "bipartite" nuclear localization sequence at the N-terminus, and highly basic amino acids at both termini. Comparison of the sequences of...
    14 KB (1,634 words) - 01:39, 1 December 2023
  • Thumbnail for U1 spliceosomal RNA
    U1 spliceosomal RNA (category Small nuclear RNA)
    called FUS (ideally, FUS should localize to the nucleus since it possesses an exposed nuclear localization sequence). The authors of this study also...
    11 KB (1,314 words) - 17:41, 4 August 2024