(AN2) or oculorhombin, is a protein that in humans is encoded by the PAX6 gene. PAX6 is a member of the Pax gene family which is responsible for carrying...

ataxia). The AN2 region of the short arm of chromosome 11 (11p13) includes the PAX6 gene (named for its PAired boX status), whose gene product helps regulate...

the PAX6 ocular development gene and the Wilms' tumour gene (WT1). Abnormalities in WT1 may also cause genitourinary anomalies. Mutations in the PAX6 gene...

factors include the genes EMX2 and PAX6. Together, both transcription factors form an opposing gradient of expression. Pax6 is highly expressed at the rostral...

due to independent variants of Pax6 arising in both cephalopods and vertebrates. Cephalopods contain five variants of Pax6 in their genomes which independently...

and usually a partial, or in the case of four family members (PAX3, PAX4, PAX6 and PAX7), a complete homeodomain to the C-terminus. An octapeptide as well...

control differentiation along major body axes, and pax genes (especially PAX6) help to control the development of the eye and other sensory organs. The...

subsequent development of the optic vesicles regulated by the PAX6 and LHX2 proteins. The role of Pax6 in eye development was elegantly demonstrated by Walter...

application of enhancer trapping methods. He and his collaborators identified PAX6 as a master control gene for eye development, which led to a new theory about...

statocysts. These results and the rejection of the prior hypothesis that Pax6 was an ancestral Pax gene in eyes has led to the conclusion that PaxB was...

master control gene PAX6, a homeobox gene with known homologues in humans (aniridia), mice (small eye), and Drosophila (eyeless). The PAX6 gene locus is a...

proven, it is thought that SHH emitted from the prechordal plate suppresses Pax6, which causes the eye field to divide into two. If the SHH gene is mutated...

some may be highly counter-intuitive. For example, deep homologies like the pax6 genes that control the development of the eyes of vertebrates and arthropods...

retinoic acid. Retinoic acid is required ventrally along with Shh to induce Pax6 and Olig2 during differentiation of motor neurons. Three main ventral cell...

among the most important genes for patterning the eyes of insects are the Pax6 homologs eyeless (ey) and twin of eyeless (toy). Together, these genes drive...

HMX1 IGBP1 KAT6B KMT2D LRP2 MAB21L2 MAF MFRP NAA10 NDUFB11 NHS OTX2 PAX2 PAX6 PDE6D PIGL POLR1C POLR1D PORCN PQBP1 PRSS56 PTCH1 RAB3GAP1 RAB3GAP2 RARB...

2003). "Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene". Developmental...

mutations are mildly affected. In addition to HESX1, mutations in OTX2, SOX2 and PAX6 have been implicated in SOD. SOX2 mutations in SOD patients are associated...

of transcription factors—Nkx2.2, Olig2, Nkx6.1, Nkx6.2, Dbx1, Dbx2, Irx3, Pax6, and Pax7—that is regulated by the SHH gradient. These transcription factors...

gene is Pax6/eyeless, which controls eye formation in all animals. It has been found to produce eyes in mice and Drosophila, even if mouse Pax6/eyeless...

motor neural progenitor domain (pMN). Transcription factors here include Pax6, OLIG2, Nkx-6.1, and Nkx-6.2, which are regulated by sonic hedgehog (Shh)...

receptor heterodimer physically interacts with the transcriptional activator PAX6 to inhibit glucagon gene transcription". Molecular Pharmacology. 73 (2):...

resulting regulated downstream expression of transcription factors, such as Pax6, Dlx3, Sox2, and others, within the presumptive olfactory placode are crucial...

ISX; LEUTX; MIXL1; NOBOX; OTP; OTX1, OTX2, CRX; PAX2, PAX3, PAX4, PAX5, PAX6, PAX7, PAX8; PHOX2A, PHOX2B; PITX1, PITX2, PITX3; PROP1; PRRX1, PRRX2; RAX...

3.2 PAX2 Papillorenal syndrome PAX3 Waardenburg syndrome 1&3 PAX4 MODY 9 PAX6 Gillespie syndrome Coloboma of optic nerve PAX8 Congenital hypothyroidism...

identified on the basis of their expression of different transcription factors (PAX6, NKX6.1) and cell surface markers (reelin and SLIT1). The three populations...

Foundation for the Blind, genetic dissection of Pax6 dosage requirements in the developing eye has shown that Pax6 dosage in the lens and cornea affects the...

(1997). "Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode". Development. 124 (1): 219–231...

Paired box Known motif – High-throughput in vitro [678] GTYACGSWTSRNTRVNY PAX6 ENSG00000007372 Homeodomain; Paired box Known motif – High-throughput in...

development. Several proteins control the embryonic development of the lens though PAX6 is considered the master regulator gene of this organ. Other effectors of...