Picrotoxin, also known as cocculin, is a poisonous crystalline plant compound. It was first isolated by the French pharmacist and chemist Pierre François...
17 KB (1,622 words) - 19:39, 22 December 2024
convulsant potency was strongly correlated to in vitro affinity to the picrotoxin binding site on the GABA-A receptor complex. Many GABA-A ligands, such...
9 KB (754 words) - 06:54, 20 October 2024
by interacting with the GABAA receptor-chloride channel complex at the picrotoxin binding site. In humans, lindane affects the nervous system, liver, and...
42 KB (4,157 words) - 06:38, 14 January 2025
Clomethiazole acts as a positive allosteric modulator at the barbiturate/picrotoxin site of the GABAA receptor. It works to enhance the action of the neurotransmitter...
9 KB (831 words) - 03:35, 12 January 2025
Southeast Asian and Indian climbing plant. Its fruit is the source of picrotoxin, a poisonous compound with stimulant properties. The plant is large-stemmed...
7 KB (610 words) - 02:20, 11 November 2024
Convulsants Anatoxin-a Bicuculline DMCM Flurothyl Gabazine Pentetrazol Picrotoxin Strychnine Thujone Eugeroics Adrafinil Armodafinil CRL-40,940 CRL-40,941...
239 KB (22,901 words) - 03:33, 10 February 2025
levomethadone, levorphanol, morphine, oripavine, pethidine, thebaine) Picrotoxin (i.e., picrotin and picrotoxinin) PMBA Riluzole Tropeines (e.g., bemesetron...
95 KB (9,860 words) - 23:12, 9 February 2025
included as an effort to wash out the stomach in those with strychnine or picrotoxin poisoning. In the United States the FDA requires tablets of the medication...
13 KB (1,021 words) - 00:57, 23 June 2024
by IUPHAR as a major criterion in the definition of GABAA receptors Picrotoxin Hydrastine (very similar in structure) Johnston, Graham AR (2013). "Advantages...
5 KB (316 words) - 20:39, 11 April 2024
Convulsants Anatoxin-a Bicuculline DMCM Flurothyl Gabazine Pentetrazol Picrotoxin Strychnine Thujone Eugeroics Adrafinil Armodafinil CRL-40,940 CRL-40,941...
182 KB (19,673 words) - 01:35, 7 February 2025
Both inhibition by nerve stimulation and by applied GABA are blocked by picrotoxin. GABA is primarily synthesized from glutamate via the enzyme glutamate...
53 KB (5,766 words) - 08:33, 24 January 2025
Convulsants Anatoxin-a Bicuculline DMCM Flurothyl Gabazine Pentetrazol Picrotoxin Strychnine Thujone Eugeroics Adrafinil Armodafinil CRL-40,940 CRL-40,941...
169 KB (16,506 words) - 01:21, 9 February 2025
levomethadone, levorphanol, morphine, oripavine, pethidine, thebaine) Picrotoxin (i.e., picrotin and picrotoxinin) PMBA Riluzole Tropeines (e.g., bemesetron...
78 KB (7,638 words) - 06:15, 16 February 2025
nilutamide) Oenanthotoxin Pentylenetetrazol (pentetrazol) Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) Pregnenolone sulfate...
89 KB (9,448 words) - 22:15, 10 February 2025
Convulsants Anatoxin-a Bicuculline DMCM Flurothyl Gabazine Pentetrazol Picrotoxin Strychnine Thujone Eugeroics Adrafinil Armodafinil CRL-40,940 CRL-40,941...
66 KB (22,789 words) - 18:03, 12 February 2025
the GABAA receptor. Its binding site seems to be similar to the one of picrotoxin, a potent neurotoxin and convulsant. The binding of U-93631 decreases...
2 KB (126 words) - 01:21, 7 February 2024
laudanosine, lindane, oenanthotoxin, pentylenetetrazol, phenylsilatrane, picrotoxin, radequinil, Ro15-4513, sarmazenil, suritozole, terbequinil,...
9 KB (808 words) - 16:15, 15 December 2024
substances, including: ethanol, chlorodiazepoxide, scopolamine, bicuculline, picrotoxin, and cycloheximide. Unlike other racetams, nefiracetam shows high affinity...
8 KB (737 words) - 19:13, 31 August 2024
Convulsants Anatoxin-a Bicuculline DMCM Flurothyl Gabazine Pentetrazol Picrotoxin Strychnine Thujone Eugeroics Adrafinil Armodafinil CRL-40,940 CRL-40,941...
57 KB (5,436 words) - 18:42, 13 February 2025
Convulsants Anatoxin-a Bicuculline DMCM Flurothyl Gabazine Pentetrazol Picrotoxin Strychnine Thujone Eugeroics Adrafinil Armodafinil CRL-40,940 CRL-40,941...
152 KB (14,086 words) - 04:55, 7 February 2025
levomethadone, levorphanol, morphine, oripavine, pethidine, thebaine) Picrotoxin (i.e., picrotin and picrotoxinin) PMBA Riluzole Tropeines (e.g., bemesetron...
28 KB (2,907 words) - 18:25, 9 February 2025
alcohol (ethanol), inhaled anaesthetics, kavalactones, cicutoxin, and picrotoxin, among others. Much like the GABAA receptor, the GABAB receptor is an...
55 KB (5,962 words) - 03:40, 23 December 2024
used in scientific research to study the GABA receptors. Picrotoxin Olsen, R. W (2006). "Picrotoxin-like channel blockers of GABAA receptors". Proceedings...
1 KB (67 words) - 05:49, 27 August 2021
levomethadone, levorphanol, morphine, oripavine, pethidine, thebaine) Picrotoxin (i.e., picrotin and picrotoxinin) PMBA Riluzole Tropeines (e.g., bemesetron...
78 KB (7,618 words) - 21:11, 11 January 2025
levomethadone, levorphanol, morphine, oripavine, pethidine, thebaine) Picrotoxin (i.e., picrotin and picrotoxinin) PMBA Riluzole Tropeines (e.g., bemesetron...
45 KB (4,742 words) - 22:04, 28 January 2025
Convulsants Anatoxin-a Bicuculline DMCM Flurothyl Gabazine Pentetrazol Picrotoxin Strychnine Thujone Eugeroics Adrafinil Armodafinil CRL-40,940 CRL-40,941...
36 KB (3,651 words) - 10:26, 15 February 2025
Convulsants Anatoxin-a Bicuculline DMCM Flurothyl Gabazine Pentetrazol Picrotoxin Strychnine Thujone Eugeroics Adrafinil Armodafinil CRL-40,940 CRL-40,941...
201 KB (20,111 words) - 05:50, 17 January 2025
nilutamide) Oenanthotoxin Pentylenetetrazol (pentetrazol) Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) Pregnenolone sulfate...
99 KB (10,737 words) - 19:45, 10 February 2025
levomethadone, levorphanol, morphine, oripavine, pethidine, thebaine) Picrotoxin (i.e., picrotin and picrotoxinin) PMBA Riluzole Tropeines (e.g., bemesetron...
103 KB (10,009 words) - 03:21, 10 February 2025
levomethadone, levorphanol, morphine, oripavine, pethidine, thebaine) Picrotoxin (i.e., picrotin and picrotoxinin) PMBA Riluzole Tropeines (e.g., bemesetron...
61 KB (5,572 words) - 12:12, 9 February 2025