Protease-activated receptors (PAR) are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular...
12 KB (1,250 words) - 19:00, 13 March 2024
Protease activated receptor 2 (PAR2) also known as coagulation factor II (thrombin) receptor-like 1 (F2RL1) or G-protein coupled receptor 11 (GPR11) is...
24 KB (2,715 words) - 22:33, 27 March 2024
Proteinase-activated receptor 1 (PAR1) also known as protease-activated receptor 1, coagulation factor II receptor and thrombin receptor is a protein...
19 KB (2,285 words) - 10:53, 11 May 2024
Thrombin (redirect from Activated blood-coagulation factor II)
cascade, thrombin also promotes platelet activation and aggregation via activation of protease-activated receptors on the cell membrane of the platelet....
25 KB (2,932 words) - 09:48, 19 October 2024
F2RL2 (redirect from Protease activated receptor 3)
Protease activated receptor 3 (PAR-3) also known as coagulation factor II receptor-like 2 (F2RL2) and thrombin receptor-like 2, is a protein that in humans...
7 KB (902 words) - 01:22, 23 December 2023
F2RL3 (category Transmembrane receptor stubs)
Protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3, is a protein that in humans is encoded by the F2RL3...
7 KB (931 words) - 06:34, 23 December 2023
Protein C (redirect from Activated protein C)
Science published an article that first showed protein C activates protease-activated receptor-1 (PAR-1) and this process accounts for the protein's modulation...
47 KB (5,344 words) - 09:14, 21 September 2024
typically bind within the transmembrane domain. However, protease-activated receptors are activated by cleavage of part of their extracellular domain. The...
82 KB (9,384 words) - 16:34, 5 September 2024
InterPro: IPR002286 Purinergic receptor P2Y10 (P2RY10, P2Y10) Protease-activated receptor InterPro: IPR003912 Coagulation factor II (thrombin) receptor-like 1 (F2RL1,...
25 KB (2,172 words) - 01:01, 29 November 2023
three known thrombin receptors (ThrR), termed PAR1, PAR3 and PAR4 (PAR for protease-activated receptor). G-protein-coupled receptors that are responsible...
5 KB (591 words) - 02:36, 29 November 2023
files. The second version is known as PAR2. Protease activated receptor 2, a G-protein coupled receptor protein PAR2, one of the pseudoautosomal regions...
304 bytes (78 words) - 22:12, 25 February 2016
Zontivity, formerly known as SCH 530348) is a thrombin receptor (protease-activated receptor, PAR-1) antagonist based on the natural product himbacine...
12 KB (995 words) - 09:08, 5 September 2024
protease inhibitor (serpin) that functions as the principal inhibitor of tissue-type plasminogen activator (tPA) and urokinase (uPA), the activators of...
13 KB (1,603 words) - 02:15, 10 March 2024
serine proteases. Activated mast cells also synthesize and secrete lipid-derived mediators (such as prostaglandins, leukotrienes, and platelet-activating factor)...
42 KB (4,735 words) - 21:19, 8 October 2024
inhibitors Cilostazol (Pletaal) Protease-activated receptor-1 antagonists (which inhibit the protease-activated receptor 1 a.k.a. PAR-1) Vorapaxar (Zontivity)...
18 KB (1,752 words) - 10:58, 11 August 2024
extracellular targets for GrK such as the cleavage and activation of protease activated receptors (PAR)-1 and PAR-2. Grk binds lipopolysaccharides (LPS)...
10 KB (1,274 words) - 02:10, 27 January 2024
Urokinase (redirect from Urinary plasminogen activator)
Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals. The human urokinase protein...
20 KB (2,290 words) - 08:54, 4 May 2024
2023). "Protease secretions by the invading blastocyst induce calcium oscillations in endometrial epithelial cells via the protease-activated receptor 2"....
51 KB (5,914 words) - 21:10, 16 August 2024
Proteolysis (section Protease enzymes)
factors, and receptors, for example in the biosynthesis of cholesterol, or the mediation of thrombin signalling through protease-activated receptors. Some enzymes...
34 KB (4,246 words) - 02:50, 14 August 2024
responses are activated by TF/VIIa-mediated cleavage by the protease-activated receptor 2 (PAR2). EphB2 and EphA2 of the Eph tyrosine kinase receptor (RTK) family...
15 KB (1,878 words) - 08:38, 20 August 2024
designed to have more activity at protease-activated receptor 1 (PAR-1) and less anticoagulative effect than activated protein C. "First Patients Dosed...
5 KB (353 words) - 03:52, 6 July 2024
vasoconstriction and vasodilation, respectively. Although α receptors are less sensitive to epinephrine, when activated at pharmacologic doses, they override the vasodilation...
33 KB (2,982 words) - 11:42, 7 August 2024
The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors. This receptor is activated by the biogenic...
15 KB (1,740 words) - 16:17, 21 August 2024
computer files. The third version is known as PAR3. Protease activated receptor 3, a G-protein coupled receptor protein Pseudoautosomal region 3, a region of...
466 bytes (97 words) - 06:51, 31 May 2022
Skin whitening (section MC1R receptor and cAMP)
some skin whitening agents. The protease-activated receptor 2 (PAR2) is a transmembrane and G-protein coupled receptor expressed in keratinocytes and involved...
67 KB (7,644 words) - 13:03, 4 October 2024
Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor) is a protein that in humans is encoded by the PROCR gene...
14 KB (1,711 words) - 15:45, 11 June 2024
CXCR1, insulin-like family peptide receptor 2, protease-activated receptor 2, β2-adrenergic receptor and C3a receptor. The emitted photons from excited...
19 KB (2,421 words) - 16:47, 5 March 2024
mechanical cell injury, pattern recognition receptor (PRR) and protease-activated receptor (PAR) activation, stimulation by certain cytokines, chemical...
23 KB (2,415 words) - 21:50, 4 February 2024
ligand binds to the ADRB-1 Receptor, the alpha-subunit of the heterotrimeric G-protein gets activated, which in turn, activates the enzyme adenylyl cyclase...
31 KB (3,742 words) - 12:46, 12 October 2024
Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain...
32 KB (2,892 words) - 19:36, 9 October 2024