SGLT2 inhibitors (also called gliflozins or flozins) are a class of medications that inhibit sodium-glucose transport proteins in the nephron (the functional...
44 KB (4,559 words) - 22:03, 7 July 2024
adverse event, it is thought to be more common if someone receiving an SGLT2 inhibitor who is also receiving insulin has reduced or missed insulin doses....
44 KB (5,086 words) - 23:38, 11 September 2024
of the small intestine (SGLT1) and the proximal tubule of the nephron (SGLT2 in PCT and SGLT1 in PST). They contribute to renal glucose reabsorption...
16 KB (1,628 words) - 07:01, 15 October 2024
Diabetes medication (section SGLT2 inhibitors)
absorbed from the gastrointestinal tract. SGLT2 inhibition: Inhibition of sodium-glucose transport protein 2 (SGLT2) decreases glucose reabsorption in the...
50 KB (5,222 words) - 18:06, 23 August 2024
Canagliflozin (category SGLT2 inhibitors)
not recommended. Canagliflozin is a sodium-glucose cotransporter-2 (SGLT2) inhibitor. It works by increasing the amount of glucose lost in the urine. Canagliflozin...
29 KB (2,960 words) - 20:56, 4 September 2024
Sodium/glucose cotransporter 2 (redirect from SGLT2)
cotransporter 2 (SGLT2) is a protein that in humans is encoded by the SLC5A2 (solute carrier family 5 (sodium/glucose cotransporter)) gene. SGLT2 is a member...
8 KB (948 words) - 16:33, 8 October 2024
Dapagliflozin (category SGLT2 inhibitors)
in adults with type 2 diabetes. Dapagliflozin, in addition to other SGLT2-inhibitors, was shown to reduce the rate of decline in kidney function and kidney...
53 KB (4,975 words) - 03:43, 30 September 2024
(ADA) standards of medical care in diabetes include GLP-1 agonist or SGLT2 inhibitor as a first line pharmacological therapy for type 2 diabetes in patients...
42 KB (4,486 words) - 01:45, 19 October 2024
Empagliflozin (category SGLT2 inhibitors)
surgery, the FDA has approved changes to the prescribing information for SGLT2 inhibitor diabetes medicines to recommend they be stopped temporarily before...
41 KB (3,676 words) - 19:19, 4 October 2024
the Study of Diabetes recommend using a GLP-1 receptor agonist or SGLT2 inhibitor as the first-line treatment in patients who have or are at high risk...
105 KB (11,337 words) - 11:10, 13 October 2024
they frequently develop low blood pressure. In patients with HFpEF, SGLT2 inhibitors carry a class 2a recommendation according to the 2022 ACC/AHA/HFSA...
64 KB (7,334 words) - 17:05, 11 September 2024
steroids, or malignancy. Fournier gangrene is a rare side effect of SGLT2 inhibitors (canagliflozin, dapagliflozin, and empagliflozin), which increase the...
11 KB (921 words) - 22:19, 21 August 2024
A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase...
16 KB (1,723 words) - 17:39, 13 September 2024
dipeptidyl peptidase-4 (DPP-4) inhibitors. However, studies assessing risk of rheumatoid arthritis among DPP-4 inhibitor users have been inconclusive....
16 KB (1,798 words) - 07:40, 1 February 2024
state of ketosis, especially several classes of diabetes medication. SGLT2 inhibitor medications have been associated with cases of euglycemic ketoacidosis...
25 KB (2,929 words) - 11:48, 27 August 2024
Ipragliflozin (category SGLT2 inhibitors)
cotransporter 2 (SGLT2) inhibitor (gliflozin). These membrane proteins are on the cell surface and transfer glucose into the cells. SGLT2 is one subtype...
12 KB (1,110 words) - 00:39, 13 September 2024
reductase inhibitors Epalrestat Fidarestat§ Ranirestat† Tolrestat‡ Zenarestat§ Alpha-glucosidase inhibitors Acarbose Miglitol Voglibose SGLT2 inhibitors/"gliflozins"...
44 KB (3,492 words) - 22:47, 19 October 2024
Additionally, SGLT2 inhibitor medications ("gliflozins" or "flozins") produce glycosuria as their primary mechanism of action, by inhibiting sodium/glucose...
6 KB (560 words) - 05:20, 19 August 2024
along with beta blockers, mineralocorticoid receptor antagonists and SGLT2 inhibitors are recommended. Diuretics may also be prescribed to prevent fluid...
144 KB (15,658 words) - 19:43, 19 October 2024
Research 12.2 (2015): 90–100. PMC. Web. 11 Nov. 2017 Story of Discovery: SGLT2 Inhibitors: Harnessing the Kidneys to Help Treat Diabetes.” National Institute...
31 KB (3,826 words) - 04:03, 30 September 2024
Sotagliflozin (category SGLT2 inhibitors)
death due to heart failure. It is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It is taken by mouth. The most common side effect is genital infection...
14 KB (1,064 words) - 18:46, 17 July 2024
Discovery and development of gliflozins (redirect from Discovery and development of SGLT-2 inhibitors)
Trial of SGLT2 Antisense Drug". van Meer L, van Dongen M, Moerland M, de Kam M, Cohen A, Burggraaf J (February 2017). "Novel SGLT2 inhibitor: first-in-man...
26 KB (3,188 words) - 18:13, 22 September 2024
in a patient taking an alpha-glucosidase inhibitor.[citation needed] Alpha-glucosidase Alpha amylase inhibitor Jang MU, Kang HJ, Jeong CK, Kang Y, Park...
12 KB (1,431 words) - 06:10, 6 May 2024
reductase inhibitors Epalrestat Fidarestat§ Ranirestat† Tolrestat‡ Zenarestat§ Alpha-glucosidase inhibitors Acarbose Miglitol Voglibose SGLT2 inhibitors/"gliflozins"...
6 KB (508 words) - 06:49, 20 December 2023
Ertugliflozin (category SGLT2 inhibitors)
reproductive system. Ertugliflozin is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is in the class of drugs known as gliflozins. In the United States...
12 KB (888 words) - 02:32, 16 July 2024
Three classes of diabetes medications – GLP-1 agonists, DPP-4 inhibitors, and SGLT2 inhibitors– are also thought to slow the progression of diabetic nephropathy...
45 KB (5,134 words) - 06:36, 20 July 2024
Empagliflozin/linagliptin/metformin (category SGLT2 inhibitors)
surgery, the FDA has approved changes to the prescribing information for SGLT2 inhibitor diabetes medications, recommending they be temporarily stopped before...
8 KB (357 words) - 17:49, 22 September 2024
cotransporter 2. Additionally, SGLT2 inhibitor medications produce glycosuria as their primary mechanism of action, by inhibiting sodium/glucose cotransporter...
4 KB (373 words) - 15:28, 23 November 2023
Dapagliflozin/metformin (category SGLT2 inhibitors)
surgery, the FDA has approved changes to the prescribing information for SGLT2 inhibitor diabetes medicines to recommend they be stopped temporarily before...
10 KB (472 words) - 03:59, 6 July 2024
illness. Certain medications can also cause elevated ketones, such as SGLT2 inhibitors causing euglycemic ketoacidosis. Overdose of salicylates or isoniazid...
12 KB (1,178 words) - 22:33, 14 March 2024