Siglecs (Sialic acid-binding immunoglobulin-type lectins) are cell surface proteins that bind sialic acid. They are found primarily on the surface of...

CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage...

They found that 9 of the 12 marketed Siglec-Fc reagents bind to HeLa cells, and two of which, Siglec-11 and Siglec-14, had binding that was vulnerable...

of the SIGLEC9 gene. Within the siglec family of transmembrane proteins, Siglec-8 belongs to the CD33-related siglec subfamily, a subfamily that has undergone...

N-terminal IgV-domain, it is also a member of the SIGLEC family. Alternate names for sialoadhesin include siglec-1 and CD169 (cluster of differentiation 169)...

sixth member of the SIGLEC family of receptors to be identified. The protein has also been given the CD designation CD327. Siglec-6 was first found to...

Sialic acid binding Ig-like lectin 15 (Siglec-15) is a protein that in humans is encoded by the SIGLEC15 gene. Siglec-15 is predominately expressed on osteoclasts...

Crocker PR (Dec 1999). "Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes". J Biol Chem...

these osteoblasts can worsen tumors in two ways. First, they can induce SiglecFhigh-expressing neutrophil formation that in turn promotes lung tumor growth...

PMID 9373149. Cornish AL, Freeman S, Forbes G, et al. (1998). "Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33". Blood...

a humanized, nonfucosylated IgG1 monoclonal antibody that targets Siglec-8. Siglec-8 is an inhibitory receptor present on eosinophils and mast cells,...

L1 (protein), CHL1, Neurofascin and NrCAM SIGLEC family including Myelin-associated glycoprotein (MAG, SIGLEC-4), CD22 and CD83 CTX family including CTX...

characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis...

CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a...

Myelin-associated glycoprotein (MAG, Siglec-4) is a type 1 transmembrane protein glycoprotein localized in periaxonal Schwann cell and oligodendrocyte...

mammalian glycan-binding proteins (GBPs): C-type lectin, galectin, and SIGLEC immune receptors that bind carbohydrates: CD1, T cell receptor, and anti-carbohydrate...

CD8+T 2 HLA-E SHP-1, SHP-2 CD31 My, platelet, EC, T, NK 1 CD31 SHP-1, SHP-2 SIGLEC family Hm 1-4 Sialic acid SHP-1, SHP-2 CD66 Hm, EC 2 CD66 SHP-1, SHP-2 ILTs/LIRs...

the SIGLEC10 gene. Siglec-G is often referred to as the murine paralog of human Siglec-10 Like most but not all other Siglecs, Siglec-10 bears an ITIM (Immunoreceptor...

inhibitory receptor Siglec-11, but induces an opposing response through interactions with the paired activating receptor Siglec-16, exemplifying the...

charged carboxyl group at C1. Sialidosis Sialoglycoprotein Sialyltransferase Siglec Orthomyxoviridae Varki, Ajit; Roland Schauer (2008). "Sialic Acids". in...

sialidase-mediated disruption of the CD24-SiglecG interaction. Nat Biotechnol 2011; 29:428–435. [4] Liu Y, Chen GY, Zheng P.CD24-Siglec G/10 discriminates danger- from...

Vadastuximab talirine is an antibody-drug conjugate (ADC) directed to CD33 (siglec-3) which is a transmembrane receptor expressed on cells of myeloid lineage...

neutrophils, macrophages, dendritic cells and activated T-cells (SIGLEC9). SIGLECs 7 and 9 suppress the immune function of these cells by binding to terminal...

its N-terminus. It is a member of the immunoglobulin superfamily and the SIGLEC family. CD22 functions as an inhibitory receptor for B cell receptor (BCR)...

PILR-associating neural protein (PANP), HSV-1 glycoprotein B PILRA, PILRB SIGLEC family Endogenous and pathogen-derived sialylated glycans SIGLEC1, SIGLEC8...

an extracellular domain with a siglec-like immunoglobulin fold that substitutes hydrophobic interactions for the siglec fold's characteristic disulfide...

the mechanism by which this occurs is not yet fully understood. Recently, Siglec-15 has also been identified as an immune suppressive molecule that is solely...

AP; Rasmussen, HS; Rothenberg, ME; Hirano, I (22 October 2020). "Anti-Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis". The New England Journal...

PMC 3322476. PMID 19725119. Liu Y, Chen GY, Zheng P (December 2009). "CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns"...

an extracellular domain with a siglec-like immunoglobulin fold that substitutes hydrophobic interactions for the siglec fold's characteristic disulfide...