Members of the signal transducer and activator of transcription (STAT) protein family are intracellular transcription factors that mediate many aspects...
6 KB (514 words) - 21:03, 25 November 2022
attributes of an inode Stat (TV series), an American sitcom that aired in 1991 Stat (website), a health-oriented news website STAT protein, a signal transducer...
992 bytes (155 words) - 03:48, 14 December 2023
The JAK-STAT signaling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell...
62 KB (6,845 words) - 18:30, 22 August 2024
STAT inhibitors are drugs which target signal transducer and activator of transcription (STAT) proteins, a family of cytoplasmic induction factors. Inhibitors...
795 bytes (79 words) - 13:01, 23 February 2024
STAT1 (redirect from Germline STAT 1 Mutation)
humans is encoded by the STAT1 gene. It is a member of the STAT protein family. All STAT molecules are phosphorylated by receptor associated kinases...
31 KB (3,702 words) - 10:57, 15 July 2024
Protein inhibitor of activated STAT (PIAS), also known as E3 SUMO-protein ligase PIAS, is a protein that regulates transcription in mammals. PIAS proteins...
30 KB (3,257 words) - 13:01, 19 June 2024
is Janus kinase (JAK), many of whose effects are mediated by STAT proteins. (See JAK-STAT pathway.) Some kinases have dual-specificity kinase activities...
15 KB (1,635 words) - 23:25, 13 August 2024
Horsch K, Daly JM, Hynes NE (June 1999). "ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases". The Journal of...
28 KB (3,166 words) - 19:57, 8 August 2024
(SOCS3 or SOCS-3) is a protein that in humans is encoded by the SOCS3 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known...
16 KB (1,922 words) - 21:02, 8 November 2023
Paracrine signaling (section JAK-STAT pathway)
attract STAT proteins. The STAT proteins dimerize and enter the nucleus to act as transcription factors to alter gene expression. In particular, the STATs transcribe...
46 KB (4,967 words) - 21:12, 7 July 2024
Interferon gamma (section JAK-STAT pathway)
more commonly referred to as the JAK-STAT pathway. In the JAK-STAT pathway, activated JAK1 and JAK2 proteins regulate the phosphorylation of tyrosine...
56 KB (6,476 words) - 06:27, 13 September 2024
Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding...
22 KB (2,807 words) - 06:22, 27 August 2024
STAT2 (category Proteins)
transcription 2 is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family. This protein is critical to the biological...
27 KB (3,269 words) - 15:27, 3 March 2024
Janus kinase (redirect from Janus protein kinase)
non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. They were initially named "just another kinase" 1 and 2 (since they...
9 KB (974 words) - 14:46, 22 June 2024
λεπτός leptos, "thin" or "light" or "small"), also known as obese protein, is a protein hormone predominantly made by adipocytes (cells of adipose tissue)...
113 KB (13,115 words) - 03:02, 28 July 2024
IFNA2 (section Protein family)
members of the family Signal Transducer and Activator of Transcription (STAT protein); phosphorylated STAT1 and STAT2 bind IRF9 forming a complex named "IFN-Stimulated...
20 KB (2,608 words) - 08:06, 11 January 2024
SUMO-protein ligase PIAS4 is one of several protein inhibitor of activated STAT (PIAS) proteins. It is also known as protein inhibitor of activated STAT protein...
9 KB (1,158 words) - 06:57, 28 September 2024
activation of the JAK/STAT (Janus kinase/signal transducer and activator of transcription) and MAPK (mitogen activated protein kinase) cascades.[citation...
13 KB (1,583 words) - 04:50, 17 August 2024
STAT6 (category Proteins)
the Signal Transducer and Activator of Transcription (STAT) family of proteins. The proteins of STAT family transmit signals from a receptor complex to the...
18 KB (2,073 words) - 05:43, 22 July 2024
Interleukin 6 (section Protein superfamily)
acute phase response. IL-6 is responsible for stimulating acute phase protein synthesis, as well as the production of neutrophils in the bone marrow...
63 KB (7,473 words) - 11:32, 1 September 2024
Philadelphia chromosome (redirect from Bcr-abl fusion protein)
region BCR gene of chromosome 22, coding for a hybrid protein: a tyrosine kinase signaling protein that is "always on", causing the cell to divide uncontrollably...
29 KB (3,538 words) - 15:01, 5 December 2023
signal proteins of the signal transducer and activator of transcription (STAT) protein family – which include transcription factors for target genes that serve...
20 KB (2,259 words) - 11:36, 29 July 2024
encodes for the 770 amino acid protein, STAT3. STAT3 is part of a family of proteins known as the STAT protein. These proteins play an essential role in chemical...
14 KB (1,528 words) - 23:00, 25 September 2024
simply as growth hormone (GH) somatotropin, is a protein that in humans is encoded by the GH1 gene. The protein encoded by this gene is a member of the somatotropin/prolactin...
3 KB (404 words) - 17:33, 11 November 2023
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved...
24 KB (2,754 words) - 12:17, 1 October 2024
histamine secretion positive regulation of tyrosine phosphorylation of STAT protein cellular response to granulocyte macrophage colony-stimulating factor...
17 KB (1,672 words) - 11:59, 30 August 2023
RET proto-oncogene (redirect from RET protein)
the RET gene results in the production of 3 different isoforms of the protein RET. RET51, RET43 and RET9 contain 51, 43 and 9 amino acids in their C-terminal...
21 KB (2,385 words) - 03:45, 16 December 2023
Insulin-like growth factor 1 (category Aging-related proteins)
was termed "nonsuppressible insulin-like activity" (NSILA). IGF-1 is a protein that in humans is encoded by the IGF1 gene. IGF-1 consists of 70 amino...
35 KB (4,573 words) - 09:59, 28 August 2024