A single-domain antibody (sdAb), also known as a Nanobody, is an antibody fragment consisting of a single monomeric variable antibody domain. Like a whole...

Single domain can refer to: Single-domain antibody, an antibody fragment consisting of a single variable domain Single domain (magnetic), state of a ferromagnet...

Monoclonal antibody Neutralizing antibody Optimer Ligand Secondary antibodies Single-domain antibody Slope spectroscopy Surrobody Synthetic antibody Western...

the development of a new type of antibody fragments with potential use as drugs, so-called single-domain antibodies. In 1989 a group of biologists led...

scFv: single-chain variable fragment di-scFv: dimeric single-chain variable fragment sdAb: single-domain antibody BsAb: bispecific monoclonal antibody: 3funct:...

antibody, an antibody lacking light chains, and can be used to produce single-domain antibodies, which are essentially the variable domain (VNAR) of an...

Humanized antibodies are antibodies from non-human species whose protein sequences have been modified to increase their similarity to antibody variants...

intracellular domains to be added to chimeric receptors with antibody-like extracellular domains, commonly single-chain fraction variable (scFv) domains, as well...

A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell lineage made by cloning a unique white blood cell. All subsequent...

trypanolytic antibodies as with many mammals. In the future, nanobody/single-domain antibody therapy will surpass natural camel antibodies by reaching...

A single-chain variable fragment (scFv) is not actually a fragment of an antibody, but instead is a fusion protein of the variable regions of the heavy...

Caplacizumab (INN; trade name Cablivi) is a bivalent single-domain antibody (VHH) designed for the treatment of thrombotic thrombocytopenic purpura (TTP)...

identified the human single-domain antibody ('human nanobody') HN3 targeting the N-lobe of GPC3 and the human monoclonal antibody HS20 targeting the heparan...

and trivalent single-chain variable fragments (ScFvs). There are also fusion proteins mimicking the variable domains of two antibodies. The furthest developed...

Antigen-antibody interaction, or antigen-antibody reaction, is a specific chemical interaction between antibodies produced by B cells of the white blood...

A Spot-tag is a 12-amino acid peptide tag recognized by a single-domain antibody (sdAb, or nanobody). Due to the small size of a Spot-tag (12 amino acids)...

(September 1997). "Selection and identification of single domain antibody fragments from camel heavy-chain antibodies". FEBS Letters. 414 (3): 521–526. doi:10...

Recombinant antibodies are antibody fragments produced by using recombinant antibody coding genes. They mostly consist of a heavy and light chain of the...

These so-called heavy-chain antibodies are being used to develop single-domain antibodies with potential pharmaceutical applications. Camelids do not have...

antibody that binds to antigens. It is composed of one constant and one variable domain of each of the heavy and the light chain. The variable domain...

possibility of modification. Nanobodies for example are natural single-domain antibodies found in camelids with an average mass of 15kDa. They bear an increased...

nomenclature of monoclonal antibodies is a naming scheme for assigning generic, or nonproprietary, names to monoclonal antibodies. An antibody is a protein that...

Antibody–drug conjugates or ADCs are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. Unlike chemotherapy, ADCs are...

such as HuSdLTM phage display human single domain antibody library Creative Biolabs offers SARS-CoV-2 S antibodies that come from common hosts like human...

virus therapy. The antibody binds to the F domain HA trimer, and prevents the virus from attaching to the host cell. The antibody has been refined in...

larger size, the new antibody was originally referred to as γ-macroglobulin, and subsequently termed IgM—M for “macro”. The V domains of normal immunoglobulin...

either labeled with a fluorophore or a single-stranded DNA strand, was used as a replacement for secondary antibodies in immunofluorescence and super-resolution...

Antibody mimetics are organic compounds that, like antibodies, can specifically bind antigens, but that are not structurally related to antibodies. They...

fragments contain the variable domains, which consist of three antibody hypervariable amino acid domains responsible for the antibody specificity embedded into...

"Structural basis for chemically-induced homodimerization of a single domain antibody". Scientific Reports. 9 (1): 1840. Bibcode:2019NatSR...9.1840L....