NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type...
13 KB (1,662 words) - 16:52, 2 December 2023
Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. SIRT1 stands for sirtuin (silent...
26 KB (3,126 words) - 05:58, 11 June 2024
Sirtuins are a family of signaling proteins involved in metabolic regulation. They are ancient in animal evolution and appear to possess a highly conserved...
28 KB (2,324 words) - 14:34, 10 July 2024
NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. SIRT2 is an NAD+ (nicotinamide adenine dinucleotide)-dependent...
29 KB (3,217 words) - 12:45, 26 September 2024
Sirtuin 6 (SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. In laboratory...
8 KB (1,028 words) - 03:08, 16 May 2023
Sirtuin-activating compounds (STAC) are chemical compounds having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from...
4 KB (421 words) - 18:48, 30 September 2024
studies). Suppression of insulin resistance by sirtuins accounts for at least some of this effect. Impaired sirtuin 3 leads to mitochondrial dysfunction. Rapamycin...
119 KB (12,658 words) - 19:25, 19 September 2024
but are completely rescued by SARM1 deletion. Activation of NMNAT2 by Sirtuin 3 (SIRT3) may be a means of inhibiting axon degeneration and dysfunction...
7 KB (828 words) - 00:07, 3 December 2023
Sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae), also known as SIRT5 is a protein which in humans in encoded by the SIRT5...
7 KB (913 words) - 23:35, 3 March 2023
NAD-dependent deacetylase sirtuin 7 is an enzyme that in humans is encoded by the SIRT7 gene. SIRT7 is member of the mammalian sirtuin family of proteins, which...
13 KB (1,531 words) - 15:25, 6 May 2024
Sirtuin 4, also known as SIRT4, is a mitochondrial protein which in humans is encoded by the SIRT4 gene. SIRT4 is member of the mammalian sirtuin family...
7 KB (853 words) - 01:11, 4 March 2023
(2018). "Regulatory Effects of NAD + Metabolic Pathways on Sirtuin Activity". Sirtuins in Health and Disease. Progress in Molecular Biology and Translational...
79 KB (9,020 words) - 19:11, 15 September 2024
found to be a potent sirtuin 6 (SIRT6) activator. Antirrhinin (cyanidin-3-rutinoside or 3-C-R), found in black raspberry Cyanidin-3-xylosylrutinoside, found...
9 KB (817 words) - 10:13, 9 April 2024
Sirtris was focused on developing Sinclair's research into activators of sirtuins, work that began in the Guarente lab. The company was specifically focused...
30 KB (2,746 words) - 02:01, 12 August 2024
was developed by GlaxoSmithKline as a small-molecule activator of the sirtuin subtype SIRT1, with potential applications in the treatment of diabetes...
3 KB (164 words) - 11:19, 24 September 2024
SUCNR1 (category Genes on human chromosome 3)
PMID 31903720. Li YH, Choi DH, Lee EH, Seo SR, Lee S, Cho EH (May 2016). "Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the...
73 KB (9,236 words) - 23:47, 12 September 2024
level of stimulation can vary between individual fruits. Fisetin is a sirtuin-activating compound and has been shown in laboratory studies to extend...
21 KB (2,080 words) - 04:07, 27 May 2024
unsettled. Because NADH is a cofactor for processes inside mitochondria, for sirtuins and PARP, NMN has been studied in animal models as a potential neuroprotective...
18 KB (1,681 words) - 01:33, 28 June 2024
several co-repressors, including HDAC1 (histone deacetylase 1) and SIRT 1 (sirtuin 1). ... The net result is c-fos gene repression. Figure 4: Epigenetic basis...
273 KB (26,900 words) - 06:46, 25 September 2024
causes the upregulation of sirtuin 1 protein, which disrupts the transcription factor for AIM2, RelB. Knockdown of sirtuin 1 upregulates AIM2 expression...
35 KB (3,948 words) - 06:00, 10 June 2024
endproducts inhibitory effects. It is also a sirtuin-activating compound, a chemical compound having an effect on sirtuins, a group of enzymes that use NAD+ to...
3 KB (228 words) - 13:34, 13 March 2024
glucose tolerance. miR-34a represses the translation of sirtuin 1 (SIRT1) in liver by binding to the 3′-UTR region of SIRT1 messenger RNA, contributing to...
9 KB (1,123 words) - 16:24, 5 August 2024
phosphate synthetase I (CPS I), interacts with a class of molecules called sirtuins, NAD dependent protein deacetylases, and ATP to form carbamoyl phosphate...
4 KB (355 words) - 14:47, 5 January 2024
blocks are released from the vesicle through the action of permeases. Sirtuin 1 (SIRT1) stimulates autophagy by preventing acetylation of proteins (via...
77 KB (9,112 words) - 23:14, 20 September 2024
deacetylase (HDAC) families of enzymes, but not class III HDACs (i.e., sirtuins). However, there are recent reports of the interactions of this molecule...
8 KB (690 words) - 12:36, 1 June 2024
insulin by binding to their PPAR receptors Agents that modulate sirtuins (called STAC –sirtuin-activating compounds), for example, fisetin Exanadin (exenatide)...
23 KB (2,847 words) - 12:04, 25 March 2024
Guarente L (March 2014). "SIRT1 and other sirtuins in metabolism". Trends in Endocrinology and Metabolism. 25 (3): 138–145. doi:10.1016/j.tem.2013.12.001...
24 KB (2,650 words) - 17:26, 1 July 2024
suppress, gluconeogenesis and ketogenesis. Because SGLT2 inhibitors activate sirtuin 1 (and thus PGC-1α and FGF21), they are more cardioprotective than the...
44 KB (4,559 words) - 22:03, 7 July 2024
several co-repressors, including HDAC1 (histone deacetylase 1) and SIRT 1 (sirtuin 1). ... The net result is c-fos gene repression. Figure 4: Epigenetic basis...
57 KB (21,441 words) - 18:05, 24 September 2024
tacedinaline (CI994), zabadinostat, and mocetinostat (MGCD0103). The sirtuin Class III HDACs are dependent on NAD+ and are, therefore, inhibited by...
26 KB (2,974 words) - 05:26, 31 May 2024