Sulfanilamide (also spelled sulphanilamide) is a sulfonamide antibacterial drug. Chemically, it is an organic compound consisting of an aniline derivatized...

Elixir sulfanilamide was an improperly prepared sulfonamide antibiotic that caused mass poisoning in the United States in 1937. It is believed to have...

the inactive dye portion a smaller, colorless, active compound called sulfanilamide. The discovery helped establish the concept of "bioactivation" and dashed...

became the first oral version of sulfanilamide by Bayer, which had actually obtained a German patent on sulfanilamide as early as 1909, without realizing...

medical experiments revolving around food, seawater, epidemic jaundice, sulfanilamide, blood coagulation and phlegmon. According to the indictments at the...

aniline derivative and a coupling agent. The most common arrangements use sulfanilamide and N-(1-naphthyl)ethylenediamine: a typical commercial Griess reagent...

Neosalvarsan 1935 – Prontosil (an oral precursor to sulfanilamide), the first sulfonamide 1936 – Sulfanilamide 1938 – Sulfapyridine (M&B 693) 1939 – sulfacetamide...

sometimes used as a synonym for sulfa drug, a derivative or variation of sulfanilamide. The first sulfonamide was discovered in Germany in 1932. Sulfonamides...

the elixir sulfanilamide disaster of 1937, described as one of the most consequential mass poisonings of the 20th century. Elixir sulfanilamide was formulated...

rapidly enacted into law following the public outcry over the 1937 Elixir Sulfanilamide tragedy, in which over 100 people died after using a drug formulated...

influenced by the death of more than 100 patients due to elixir sulfanilamide, a sulfanilamide medication where the toxic solvent diethylene glycol was used...

regulation of drug development and drug sales. In the U.S., the Elixir Sulfanilamide disaster led to the establishment of the Food and Drug Administration...

people died in the United States after ingesting DEG-contaminated elixir sulfanilamide, a drug used to treat infections. The origin of the gly- and glu- prefixes...

of the drug sulfanilamide. They mixed it with a 10% solution of sulfanilamide in diethylene glycol. They called it “Elixir of Sulfanilamide", and distributed...

chlorothiazide, the first thiazide diuretic and developed from the antibiotic sulfanilamide, which became available in 1958. Subsequently, beta blockers, calcium...

hypersensitivity to trimethoprim or sulfonamides. Sulfamethoxazole, a sulfanilamide, is a structural analog of para-aminobenzoic acid (PABA). They compete...

1937 Elixir sulfanilamide incident: S. E. Massengill Company used diethylene glycol as the solvent for the antibacterial sulfanilamide, leading to the...

drug's ingredients. In 1937 over 100 people died after ingesting "Elixir Sulfanilamide" manufactured by S.E. Massengill Company of Tennessee. The product was...

1932), must be cleaved in the body to release the active molecule, sulfanilamide. Since that time, many other examples have been identified. Terfenadine...

sulfanilamide dissolved with diethylene glycol, to create a liquid alternative of this drug. The company tested the new product, Elixir sulfanilamide...

manufactured products. Major incidents include: deaths from Elixir Sulfanilamide in 1937, thalidomide-induced birthdefects 1957-1961, poliomyelitis infections...

explosion Sayreville, New Jersey Fatalities estimated 100+ 1937 Elixir sulfanilamide Mass poisoning United States 100 1978 Northeastern United States blizzard...

cell DNA replication. Antimetabolites may also be antibiotics, such as sulfanilamide drugs, which inhibit dihydrofolate synthesis in bacteria by competing...

J01EB03 Sulfadimidine J01EB04 Sulfapyridine J01EB05 Sulfafurazole J01EB06 Sulfanilamide J01EB07 Sulfathiazole J01EB08 Sulfathiourea J01EB20 Combinations J01EC01...

thousands of deaths worldwide since the first recorded case: the Elixir sulfanilamide incident in 1937. DEG was commonly misconceived of as being ethylene...

Buchenwald and Natzweiler. Genzken was also accused of involvement in sulfanilamide experiments, poison experiments, and incendiary bomb experiments but...

Jungle by Upton Sinclair led to 1906 Pure Food and Drugs Act Elixir of sulfanilamide led to the 1938 Food Drug and Cosmetic Act Thalidomide led to the 1962...

was an Austrian chemist who worked on synthetic dyes and discovered sulfanilamide in 1908, although their antibiotic properties were discovered only in...

over food and drugs. In the 1930s, a new antibacterial drug called sulfanilamide was synthesized and was widely accepted. One chemist at S.E. Massengill...

Sulfapyridine (INN; also known as sulphapyridine) is a sulfanilamide antibacterial medication. At one time, it was commonly referred to as M&B 693. Sulfapyridine...