Transmembrane protease, serine 2 is an enzyme that in humans is encoded by the TMPRSS2 gene. It belongs to the TMPRSS family of proteins, whose members are transmembrane...
24 KB (2,578 words) - 19:43, 24 August 2024
ERG (gene) (section TMPRSS2 gene fusion)
consequences for cells. Examples of these fusion gene products would be TMPRSS2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing’s sarcoma, and FUS-ERG...
19 KB (2,303 words) - 10:18, 13 May 2024
Jahn O, Pöhlmann S (January 2014). "TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe...
52 KB (5,899 words) - 06:01, 22 August 2024
priming virus's Spike protein to show the protein named "fusion protein" (TMPRSS2 activate SARS-CoV-2 fusion). Exogenous snake venom serine proteases cause...
22 KB (2,343 words) - 20:13, 29 August 2024
urine levels of mRNA molecules common to prostate tumors like PCA3 and TMPRSS2 fused to ERG. Several large studies have found that men screened for prostate...
76 KB (8,857 words) - 19:54, 30 September 2024
t(8 ; 21)), and TMPRSS2-ERG with an interstitial deletion on chromosome 21, often occurring in prostate cancer. In the case of TMPRSS2-ERG, by disrupting...
17 KB (1,928 words) - 19:40, 5 August 2024
spike protein variants that can enhance syncytia formation. The protease TMPRSS2 is essential for syncytia formation. Syncytia can allow the virus to spread...
18 KB (2,046 words) - 03:47, 22 August 2024
N-0385 is an experimental small molecule TMPRSS2-inhibitor being investigated for its potential use in the prevention and treatment of COVID-19. N-0385...
4 KB (314 words) - 22:27, 21 September 2024
entry. Initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2) is essential for entry of SARS‑CoV‑2. The host protein neuropilin 1 (NRP1)...
122 KB (12,462 words) - 03:40, 15 August 2024
protein required for viral entry into cells can be accomplished by proteases TMPRSS2 located on the cell membrane, or by cathepsins (primarily cathepsin L)...
37 KB (4,726 words) - 03:37, 30 September 2024
process also requires priming of the S protein by the host serine protease TMPRSS2, the inhibition of which is under current investigation as a potential...
44 KB (5,225 words) - 03:19, 9 May 2024
protein required for viral entry into cells can be accomplished by proteases TMPRSS2 located on the cell membrane, or by cathepsins (primarily cathepsin L)...
48 KB (5,809 words) - 00:19, 7 September 2024
such as disruption of the tumor suppressor gene PTEN or creation of the TMPRSS2-ERG fusion gene.[citation needed] Chromplexy was originally inferred by...
7 KB (922 words) - 22:01, 24 August 2024
proteases such as cathepsin family and transmembrane protease serine 2 (TMPRSS2) of the host cell. S1 proteins are the most critical components in terms...
96 KB (10,573 words) - 17:35, 11 September 2024
pancreatitis. It is an inhibitor of the enzyme transmembrane protease, serine 2 (TMPRSS2). For chronic pancreatitis camostat's typical dose is 600 mg daily, for...
12 KB (1,046 words) - 23:14, 20 February 2024
carboxypeptidase II erbB-3 receptor Early prostate cancer antigen-2 SPINK1 GOLM1 PCA3 TMPRSS2 hPG80 Germ cell tumor NANOG Bladder cancer erbB-3 receptor NMP22 Breast...
9 KB (984 words) - 06:12, 26 December 2021
protein trefoil factor 3 TIAM1: Rho guanine nucleotide exchange factor TIAM1 TMPRSS2: encoding enzyme transmembrane protease serine 2 TMPRSS3: encoding enzyme...
33 KB (3,077 words) - 19:12, 6 October 2024
drug-metabolizing enzyme. Debrisoquine has been identified as a inhibitor of TMPRSS2 protease, which is involved in the viral entry process of SARS-CoV-2. In...
3 KB (199 words) - 08:32, 4 August 2024
protein required for viral entry into cells can be accomplished by proteases TMPRSS2 located on the cell membrane, or by cathepsins (primarily cathepsin L)...
61 KB (5,793 words) - 07:44, 8 October 2024
model that express the Androgen receptor splice variant, AR-V7, and the TMPRSS2-ERG gene fusion. The cells have an approximate doubling time of 53 hours...
3 KB (311 words) - 18:15, 1 September 2022
with enzalutamide, the expression of androgen-dependent genes PSA and TMPRSS2 was down regulated in contrast to bicalutamide where the expression was...
50 KB (4,674 words) - 20:52, 20 August 2024
virus, cell type, and local environment. In SARS-CoV, the serine protease TMPRSS2 is important for this process, with additional contributions from cysteine...
76 KB (7,457 words) - 07:06, 3 October 2024
bioRxiv 10.1101/2020.05.09.086249. Meng, B; et al. (March 2022). "Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity". Nature...
57 KB (6,661 words) - 09:44, 6 October 2024
2020). "New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis". BMC Medicine. 18 (1): 216. doi:10.1186/s12916-020-01673-z...
60 KB (6,946 words) - 14:27, 22 September 2024
2015). "Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced...
15 KB (1,812 words) - 22:11, 27 March 2024
Laxman B, Cao Q, Prensner JR, et al. (January 2008). "Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer". Cancer Research...
7 KB (717 words) - 20:12, 8 April 2022
and optimal cells fusion. In low cholesterol ACE2 traffics the virus to TMPRSS2 which also cleaves and allows viral entry but through a putative surface...
16 KB (1,885 words) - 06:41, 20 May 2024
protein required for viral entry into cells can be accomplished by proteases TMPRSS2 located on the cell membrane, or by cathepsins (primarily cathepsin L)...
128 KB (14,817 words) - 01:34, 9 September 2024
17066 TMPO HGNC:11875 P42166 P42167 17067 TMPPE HGNC:33865 Q6ZT21 17068 TMPRSS2 HGNC:11876 O15393 17069 TMPRSS3 HGNC:11877 P57727 17070 TMPRSS4 HGNC:11878...
242 KB (17 words) - 18:43, 6 October 2024
the cytoplasmic membrane. Adam17 has similar ACE2 cleavage activity as TMPRSS2, but by forming soluble ACE2, Adam17 may actually have the protective effect...
21 KB (2,452 words) - 05:03, 26 August 2024