Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) is an enzyme that in humans is encoded by the TPMT gene. A pseudogene for this locus...

The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease...

especially common in people with a genetic deficiency of the enzyme thiopurine S-methyltransferase. Other serious risk factors include an increased risk of certain...

Examples of methyltransferase enzymes relevant to disease: thiopurine methyltransferase: defects in this gene causes toxic accumulation of thiopurine compounds...

reduction of the thiopurine, usually to one-third of the standard dose depending upon the patient's genetic status for thiopurine methyltransferase. Allopurinol...

deficiency in thiopurine S-methyltransferase are at higher risk of side effects. Use in pregnancy may harm the baby. Mercaptopurine is in the thiopurine and antimetabolite...

when on the medication. People with a genetic deficiency in thiopurine S-methyltransferase are at higher risk of side effects. Avoiding pregnancy when...

One of his early studies investigated the correlation between thiopurine methyltransferase genotype and azathioprine toxicity in rheumatic disease patients...

PACSIN2 has been associated with the activity of the enzyme thiopurine-methyltransferase during remission maintenance therapy of children with acute lymphoblastic...

Q.; Pui, C. H.; Evans, W. E. (April 1, 1995). "Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts...

TPMT gene encodes for the thiopurine S-methyltransferase (TPMT) enzyme. It participates in the S-methylation of thiopurine drugs, which include 6-mercaptopurine...

identify variation in thiopurine response. The EMR stores quantitative value of IBD patient's TPMT (thiopurine S-methyltransferase) activity, which then...

supervision of Andres Metspalu and Kersti Oselin, was entitled Human thiopurine methyltransferase pharmacogenetics: genotype-phenotype correlation and haplotype...

3-O-methyltransferase EC 2.1.1.65: licodione 2′-O-methyltransferase EC 2.1.1.66: Now covered by EC 2.1.1.230 EC 2.1.1.67: thiopurine S-methyltransferase EC...

activity via two mechanisms – at low doses, by inhibiting of DNA methyltransferase, causing hypomethylation of DNA, and at high doses, by its direct...

and procainamide. Inheriting abnormal thiopurine S-methyltransferase may affect the metabolism of the thiopurine drugs mercaptopurine and azathioprine...

Mlinaric-Rascan I (August 2009). "Individualization of thiopurine therapy: thiopurine S-methyltransferase and beyond". Pharmacogenomics. 10 (8): 1309–1322....

when in the presence of the DNA-repair enzyme O-6-methylguanine-DNA methyltransferase (MGMT). Cross-linking of double-stranded DNA by alkylating agents...

mutations in the anthracyclines family. Studies have shown that in DNA methyltransferase 3A (DNMT3A) the most frequent mutation is seen at arginine 882 (DNMT3AR882)...

a hypomethylating agent. It hypomethylates DNA by inhibiting DNA methyltransferase. It functions in a similar manner to azacitidine, although decitabine...

available hypomethylating agents block the activity of DNA methyltransferase (DNA methyltransferase inhibitors / DNMT inhibitors). Currently two members of...

F420-dependent tetrahydromethanopterin (H4MPT) reductase and H4MPT:CoM methyltransferase Hydroxylation of C-5, C-7 (followed by transamination), and C-9a....

alkyltransferase (AGT) encoded in humans by the O-6-methylguanine-DNA methyltransferase (MGMT) gene. In some tumors, epigenetic silencing of the MGMT gene...

Kramm CM, Staege MS (January 2014). "Impact of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and MGMT expression on dacarbazine resistance...

increasing CD95 sensitivity of activated T cells; and inhibition of methyltransferase activity, leading to deactivation of enzyme activity relevant to immune...

antineoplastics 1.01 Nucleoside analogues Azacitidine SC, IV DNA methyltransferase inhibitor and incorporates itself into RNA, hence inhibiting gene...

selective EZH2 inhibitor. Tazemetostat blocks activity of the EZH2 methyltransferase, which may help keep the cancer cells from growing. Most cases of...

kynurenine formamidase, kynurenine hydroxylase, hydroxykynurenase, and methyltransferase. Early experiments elucidated the presence of non-ribosomal peptide...

RK, Hsu CH, Wang YC (November 2007). "Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells". Anti-Cancer Drugs...

inhibitors (Cladribine Clofarabine Fludarabine) Nelarabine Rabacfosadine Thiopurine (Mercaptopurine# Tioguanine#) Pyrimidine Thymidylate synthase inhibitor...