enzyme complex to form thrombin. Thrombin (Factor IIa) (EC 3.4.21.5, fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated...
26 KB (2,932 words) - 19:37, 9 May 2024
The thrombin time (TT), also known as the thrombin clotting time (TCT), is a blood test that measures the time it takes for a clot to form in the plasma...
6 KB (742 words) - 01:20, 2 August 2024
involved in the clotting of blood. It is formed by the action of the protease thrombin on fibrinogen, which causes it to polymerize. The polymerized fibrin, together...
7 KB (722 words) - 21:39, 21 April 2024
thrombin inhibitors (DTIs) are a class of medication that act as anticoagulants (delaying blood clotting) by directly inhibiting the enzyme thrombin (factor...
7 KB (821 words) - 09:44, 30 January 2023
factor X, thrombin and fibrin. The main role of the tissue factor (TF) pathway is to generate a "thrombin burst", a process by which thrombin, the most...
64 KB (6,553 words) - 13:35, 26 September 2024
A thrombin generation assay (TGA) or thrombin generation test (TGT) is a global coagulation assay (GCA) and type of coagulation test which can be used...
6 KB (614 words) - 06:17, 13 August 2023
Thrombin inhibitor may refer to: Direct thrombin inhibitor Indirect thrombin inhibitor, such as warfarin This disambiguation page lists articles associated...
133 bytes (46 words) - 16:05, 30 December 2019
There are three known thrombin receptors (ThrR), termed PAR1, PAR3 and PAR4 (PAR for protease-activated receptor). G-protein-coupled receptors that are...
5 KB (591 words) - 02:36, 29 November 2023
Fibrin glue (redirect from Fibrinogen/thrombin)
wound healing. It contains separately packaged human fibrinogen and human thrombin. This glue is used as a supportive treatment in surgery (such as liver...
16 KB (1,287 words) - 00:21, 2 October 2024
minimally-invasive technique used today is ultrasound-guided thrombin injection. Thrombin (factor IIa in the coagulation cascade) is a clotting factor...
11 KB (1,353 words) - 06:36, 19 November 2023
Prothrombin time (redirect from Quick's thrombin time)
thromboplastin time (PTT), or activated partial thromboplastin time (aPTT or APTT) Thrombin time (TT) Thrombodynamics test Thromboelastography Thrombus Health Mo....
24 KB (3,091 words) - 04:19, 1 July 2024
Activated protein C resistance test (redirect from Endogenous thrombin potential-based APC resistance assays)
to a thrombin generation assay (TGA). This results in an inhibition of thrombin generation as measured by reduction of the endogenous thrombin potential...
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Thrombin–antithrombin complex (TAT) is a protein complex of thrombin and antithrombin. It is a marker of net activation of coagulation. TAT is formed in...
6 KB (648 words) - 03:34, 13 August 2023
(factor II), an inactive zymogen, to thrombin (factor IIa), an active serine protease. The activation of thrombin is a critical reaction in the coagulation...
25 KB (3,112 words) - 19:03, 28 February 2024
"Short activated partial thromboplastin times are related to increased thrombin generation and an increased risk for thromboembolism". American Journal...
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Direct thrombin inhibitors (DTIs) are a class of anticoagulant drugs that can be used to prevent and treat embolisms and blood clots caused by various...
33 KB (3,756 words) - 17:07, 14 December 2023
Term thrombin-activatable fibrinolysis inhibitor may refer to: Carboxypeptidase B2, an enzyme that in humans is encoded by the CPB2 gene Lysine carboxypeptidase...
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Anti-thrombin aptamers are G-quadruplex-bearing oligonucleotides, which recognizes the exosites of human thrombin. The first anti-thrombin aptamer, TBA...
23 KB (2,660 words) - 05:35, 3 June 2024
interaction with thrombin. The formation of a ternary complex between AT, thrombin, and heparin results in the inactivation of thrombin. For this reason...
77 KB (7,855 words) - 18:45, 29 August 2024
endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant...
13 KB (1,470 words) - 09:00, 19 August 2024
Anti-thrombin antibodies are autoantibodies directed against thrombin that may constitute a fraction of lupus anticoagulant and are seen an increased levels...
4 KB (381 words) - 00:09, 12 December 2020
refers to the binding of thrombin to fibrin, after thrombin has activated fibrinogen, at a non-catalytic binding site of thrombin. Antithrombin II (AT II)...
46 KB (5,418 words) - 12:45, 29 August 2024
Dabigatran (category Direct thrombin inhibitors)
thrombin molecule, preventing thrombin-mediated activation of coagulation factors. Furthermore, dabigatran can inactivate thrombin even when thrombin...
41 KB (3,733 words) - 19:42, 20 September 2024
Anticoagulant (section Direct thrombin inhibitors)
non-vitamin K antagonist oral anticoagulants. These agents include direct thrombin inhibitor (dabigatran) and factor Xa inhibitor (rivaroxaban, apixaban,...
78 KB (8,755 words) - 15:35, 24 September 2024
vitamin K antagonists, direct oral anticoagulants (DOACs) and indirect thrombin inhibitors. Since cardiovascular agents have narrow therapeutic windows...
46 KB (5,032 words) - 09:46, 11 August 2024
known as protease-activated receptor 1, coagulation factor II receptor and thrombin receptor is a protein that in humans is encoded by the F2R gene. PAR1 is...
19 KB (2,285 words) - 10:53, 11 May 2024
found in the venom of Bothrops snakes, has activity similar to thrombin. Unlike thrombin, reptilase is resistant to inhibition by antithrombin III. Thus...
2 KB (189 words) - 06:33, 14 December 2023
response in the clotting system, which in turns stimulates thrombin production. Thrombin also causes platelet aggregation. As such, more often than not...
9 KB (1,278 words) - 22:10, 30 October 2023
pathway or thrombin pathway. It acts by cleaving prothrombin in two places (an Arg-Thr and then an Arg-Ile bond), which yields the active thrombin. This process...
27 KB (3,353 words) - 09:39, 12 August 2024
fibrinolysis. Excess circulating thrombin results from the excess activation of the coagulation cascade. The excess thrombin cleaves fibrinogen, which ultimately...
23 KB (2,460 words) - 07:10, 14 September 2024