In the U.S. state of North Carolina U.S. Route 221 (US 221) is a north–south highway that travels through Western North Carolina. From Chesnee, South Carolina...

U.S. Route 221 (US 221) is a 734-mile-long (1,181 km) spur of U.S. Route 21. It travels from Perry, Florida, at US 19/US 98/US 27 Alternate to Lynchburg...

U.S. Route 21 or U.S. Highway 21 (US 21) is a north–south United States Numbered Highway, spanning 393 miles (632 km) from Hunting Island State Park,...

In the U.S. state of South Carolina, U.S. Route 221 (US 221) is a 126.390-mile (203.405 km) United States Highway within the state. It is part of the...

Several special routes of U.S. Route 221 exist. In order from south to north they are as follows. U.S. Route 221 Truck (US 221 Truck) directs truck drivers...

U.S. Route 421 (US 421) is part of the United States Numbered Highway System that runs from Fort Fisher, North Carolina to Michigan City, Indiana. In...

U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with...

U.S. Route 176 (US 176) is a spur of US 76 in the U.S. states of North Carolina and South Carolina. The U.S. Highway runs 237.98 miles (382.99 km) from...

U.S. Route 70 (US 70) is a part of the United States Numbered Highway System that runs from Globe, Arizona, to the Crystal Coast of the US state of North...

Highway 78 to Rosman, North Carolina, at U.S. Highway 64. It passes through the states of South Carolina and North Carolina. It goes through the cities...

Myrtle Beach, South Carolina at U.S. Route 17 Business. It passes through the states of Virginia, North Carolina and South Carolina. From Durham to Laurinburg...

U.S. Route 74 (US 74) is an east–west United States highway that runs for 515 miles (829 km) from Chattanooga, Tennessee to Wrightsville Beach, North...

U.S. Route 401 (US 401) is a north–south United States highway, a spur of U.S. Route 1, that travels along the Fall Line from Sumter, South Carolina to...

U.S. Route 601 (US 601) is a north–south United States highway that runs for 316.3 miles (509.0 km) from U.S. Route 321, near Tarboro, South Carolina...

U.S. Route 378 (US 378) is a spur of US 78 in the U.S. states of Georgia and South Carolina. The U.S. Highway runs 234.30 miles (377.07 km) from US 78...

U.S. Route 64 (US 64) is the longest numbered route in the U.S. state of North Carolina, running 604 miles (972 km) from the Tennessee state line to the...

U.S. Route 76 (US 76) is an east–west U.S. highway in the Southeastern United States that travels for 548 miles (882 km). Its western terminus is at US...

U.S. Route 258 (US 258) is a spur of US 58 in the U.S. states of North Carolina and Virginia. The U.S. Highway runs 220.15 miles (354.30 km) from US 17...

north–south cardinal directions but is actually a northeast and southwest diagonal highway throughout the state. The route serves the North Carolina Piedmont...

U.S. Route 441 (US 441) is a 939-mile-long (1,511 km) auxiliary route of U.S. Route 41. It extends from US 41 in Miami, Florida to US 25W in Rocky Top...

routes of U.S. Route 17 (US 17) have existed: 3 in Florida, 6 in South Carolina, 17 in North Carolina, and 6 in Virginia. U.S. Highway 17 Truck (US 17...

U.S. Route 221 (US 221) is a part of the U.S. Highway System that runs from Perry, Florida to Lynchburg, Virginia. In Virginia, the U.S. Highway runs...

U.S. Route 221 (US 221) in the U.S. state of Georgia is a south–north U.S. Highway. It travels from the Florida border near the Quitman area to the South...

U.S. Route 421 (also U.S. Highway 421, US 421) is a diagonal northwest–southeast United States Numbered Highway in the states of North Carolina, Tennessee...

U.S. Route 25 or U.S. Highway 25 (US 25) is a north–south United States Numbered Highway that runs for 750 miles (1,210 km) in the Southern and Midwestern...

U.S. Route 64 (US 64) is an east–west United States highway that runs for 2,281 miles (3,672 km) from Nags Head in eastern North Carolina to just southwest...

Contrary to most other even-numbered U.S. Highways, US 52 primarily follows a northwest–southeast route, and is signed north–south or east–west depending on...

U.S. Route 74 Alternate (US 74A or US 74-A) is an alternate route of U.S. Route 74 in Western North Carolina, running from the town of Forest City to the...

U.S. Route 220 (US 220) is a north–south U.S. highway which travels from Rockingham, North Carolina, to South Waverly, Pennsylvania. In the U.S. state...

Several special routes of U.S. Route 74 exist. In order from west to east they are as follows. U.S. Route 74 Alternate (US 74A) was established in 1994, replaced...