U.S. Route 73 (US 73) is a north–south United States highway that runs for 113 miles (182 km) from northeast Kansas to southeast Nebraska. The highway's...

concurrently with U.S. Route 73. After coming up through the south end of Falls City, the U.S. Route 159 turns east (with Route 73 continuing north). After...

U.S. Route 501 (US 501) is a spur of U.S. Route 1. It runs 355 miles (571 km) from Buena Vista, Virginia at U.S. Route 60 to Myrtle Beach, South Carolina...

U.S. Route 401 (US 401) is a north–south United States highway, a spur of U.S. Route 1, that travels along the Fall Line from Sumter, South Carolina to...

U.S. Route 301 (US 301) is a spur of U.S. Route 1 running through the South Atlantic states. It runs 1,099 miles (1,769 km) from Biddles Corner, Delaware...

U.S. Route 460 (US 460) is an auxiliary route of U.S. Route 60. It currently runs for 655 miles (1,054 km) from Norfolk, Virginia, at its parent route...

U.S. Route 59 (US 59) is a north–south United States highway (though it was signed east–west in parts of Texas). A latecomer to the U.S. numbered route...

U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with...

U.S. Route 421 (also U.S. Highway 421, US 421) is a diagonal northwest–southeast United States Numbered Highway in the states of North Carolina, Tennessee...

U.S. Highway 350 (US 350) is a 73-mile-long (117 km) northeast–southwest United States highway located entirely within the state of Colorado. US 350 starts...

U.S. Route 221 (US 221) is a 734-mile-long (1,181 km) spur of U.S. Route 21. It travels from Perry, Florida, at US 19/US 98/US 27 Alternate to Lynchburg...

U.S. Route 20 or U.S. Highway 20 (US 20) is an east–west United States Numbered Highway that stretches from the Pacific Northwest east to New England....

U.S. Route 58 (US 58) is an east–west U.S. Highway that runs for 508 miles (818 km) from U.S. Route 25E just northwest of Harrogate, Tennessee, to U.S...

U.S. Route 220 (US 220) is a spur route of US 20. It runs in a north–south layout in the eastern United States, unlike its parent route as well as conventionally...

U.S. Route 277 (US 277, US-277) is a north–south United States Highway that is a spur route of U.S. Route 77. It no longer connects to its parent route...

U.S. Route 24 or U.S. Highway 24 (US 24) is one of the original United States Numbered Highways of 1926 which runs east and west for most of its routing...

of at least seven special routes of U.S. Route 301 exist and at least eleven have been deleted. U.S. Route 301 Alternate (US 301 Alt.) is a 6.5-mile-long...

U.S. Route 53, or U.S. Highway 53 (U.S. 53), is a north–south U.S. highway that runs for 404 miles (650 km) from La Crosse, Wisconsin to International...

U.S. Route 70 or U.S. Highway 70 (US 70) is an east–west United States highway that runs for 2,381 miles (3,832 km) from eastern North Carolina to east-central...

U.S. Route 17 or U.S. Highway 17 (US 17), also known as the Coastal Highway, is a north–south United States Numbered Highway that spans in the Southeastern...

U.S. Route 189 is a spur of U.S. Route 89. It currently runs for 322 miles (518 km) from Provo, Utah at Interstate 15 to Jackson, Wyoming. The highway...

U.S. Route 302 (US 302) is an east–west spur of U.S. Route 2 in northern New England in the United States. It currently runs 171 miles (275 km) from Montpelier...

U.S. Route 64 (US 64) is an east–west United States highway that runs for 2,281 miles (3,672 km) from Nags Head in eastern North Carolina to just southwest...

U.S. Route 75 (US 75) was a part of the United States Numbered Highway System that runs for 1,239 miles (1,994 km) from Dallas, Texas to Kittson County...

U.S. Route 202 (US 202) is a spur route of US 2. It follows a northeasterly and southwesterly direction stretching from Delaware in the south to Maine...

U.S. Route 127 (US 127) is a 758-mile-long (1,220 km) north–south U.S. Highway in the eastern half of the United States. The southern terminus of the...

U.S. Route 311 is a United States highway that runs for 62 mi (100 km) from Winston-Salem, North Carolina to near Danville, Virginia. It connects the cities...

U.S. Route 40 or U.S. Highway 40 (US 40), also known as the Main Street of America (a nickname shared with U.S. Route 66), is a major east–west United...

U.S. Route 601 (US 601) is a north–south United States highway that runs for 316.3 miles (509.0 km) from U.S. Route 321, near Tarboro, South Carolina...

U.S. Route 75 is a north–south U.S. Highway that runs 1,239 miles (1,994 km) in the central United States. The highway's northern terminus is located at...