pigmentosum, complementation group C, also known as XPC, is a protein which in humans is encoded by the XPC gene. XPC is involved in the recognition of bulky DNA...
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Xeroderma pigmentosum, complementation group C, a human gene xPC Target, a product from MathWorks XPC Golf Clubs, a proprietary brand from Golfsmith This...
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cancer types. The XPC gene is responsible for a protein which recognizes DNA during the early portion of the NER pathway. This gene can have polymorphisms...
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Genome editing (redirect from Human gene editing therapy)
industrial-scale production of two meganucleases able to cleave the human XPC gene; mutations in this gene result in Xeroderma pigmentosum, a severe monogenic disorder...
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RAD23B (redirect from RAD23B (gene))
cells. The complex of XPC-RAD23B is the initial damage recognition factor in global genomic nucleotide excision repair (GG-NER). XPC-RAD23B recognizes a...
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I-CreI derivatives cleaving sequences from the human XPC gene can induce highly efficient gene correction in mammalian cells". Journal of Molecular Biology...
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Antimutagen (section Tumor suppressor genes)
break repair by rejoining and induction of genes related to base and nucleotide excision repair such as XPA and XPC; Selenium: Induces programmed cell death...
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H3, and H4, as well as the repair protein XPC, which has been attracted to the site of the DNA damage. XPC, upon ubiquitination, is activated and initiates...
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Carcinogenesis (section Tumor suppressor genes)
Wickliffe J, Salazar J, Boldogh I, Xie J (October 2015). "Genetic Evidence for XPC-KRAS Interactions During Lung Cancer Development". Journal of Genetics and...
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pigmentosum may be caused by genetic mutations in 8 genes, which produce the following enzymes: XPA, XPB, XPC, XPD, XPE, XPF, XPG and Pol η. XPA-XPF are nucleotide...
51 KB (5,582 words) - 14:19, 15 July 2024
initially recognized. Mutations in the XPB(ERCC3) gene can lead to XP or XP combined with Cockayne syndrome. The XPC protein forms a complex with RAD23B protein...
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XPB (redirect from ERCC3 (gene))
gene can lead, in humans, to xeroderma pigmentosum (XP) or XP combined with Cockayne syndrome (XPCS). Mutant XPB cells from individuals with the XPCS...
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DDB2 (redirect from DDB2 (gene))
comparison to the sensitivities of cells defective in the other XP genes XPA, XPB, XPC, XPD, XPF and XPG. As shown by Wittschieben et al., when DDB2 is...
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Centrin 1 (redirect from CETN1 (gene))
in humans is encoded by the CETN1 gene. It belongs to the centrin family of proteins. The protein encoded by this gene plays important roles in the determination...
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ABCA1 (redirect from ABCA1 (gene))
ABCA1 has been shown to interact with: APOA1, APOE, FADD, SNTB2, and XPC. ATP-binding cassette transporter GRCh38: Ensembl release 89: ENSG00000165029...
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DNA repair (redirect from DNA repair gene)
ligase with UV-damaged DNA is independent of damage-recognition protein XPC". Journal of Cell Science. 120 (Pt 15): 2706–16. doi:10.1242/jcs.008367....
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moon), and a lion (personifying the sun) representing the spring. Known as XPc (Xerxes Persepolis c), from the portico of the Tachara. This article incorporates...
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CUL4A (redirect from CUL4A (gene))
such as XPC and histones (see next section) near the damage site. Due to its ubiquitination of DNA damage-recognizing proteins DDB2 and XPC, CUL4A has...
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A number of gene mutations have been linked to conditions of or affecting the human integumentary system. List of radiographic findings associated with...
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- gel shift assay - gene - gene amplification - gene conversion - gene expression - gene mapping - gene pool - gene therapy - gene transfer - genetic code...
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ERCC2 (redirect from ERCC2 gene)
combination of XP and TTD (XPTTD), or a combination of XP and Cockayne syndrome (XPCS). TTD and CS both display features of premature aging. These features may...
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349 kg (770 lb) with wrist wraps and without a belt on March 7, 2020, at the XPC Powerlifting Coalition. raw 355 kg (783 lb) 2021 Julius Maddox presses 355 kg...
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RAD23A (redirect from RAD23A (gene))
repair gene RAD23". Genomics. 31 (1): 20–27. doi:10.1006/geno.1996.0004. hdl:1765/3097. PMID 8808275. Li L, Lu X, Peterson C, Legerski R (1997). "XPC interacts...
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DNA repair-deficiency disorder (redirect from Inherited human DNA repair gene mutations that increase cancer risk)
"accelerated aging" or cancer (often some of both). But elimination of any gene essential for base excision repair kills the embryo—it is too lethal to display...
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"Statistics & download files". www.genenames.org. HUGO Gene Nomenclature Committee. 1 October 2024. Retrieved 1 October 2024....
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changes in the DNA helical structure. Bulky adducts seem to trigger NER. The XPC-RAD23-CETN2 heterotrimer involved with NER has a critical role in DNA lesion...
29 KB (3,552 words) - 17:53, 31 October 2024
can be caused by mutations in any of these genes: DDB2, ERCC2, ERCC3, ERCC4, ERCC5, XPA, XPC. These genes are all involved in the NER repair pathway that...
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Valosin-containing protein (redirect from VCP (gene))
proteins DDB2 and XPC, mitosis regulator Aurora B, and certain DNA polymerases in mammalian cells. These substrates link VCP function to gene transcription...
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Centrin 2 (redirect from CETN2 (gene))
and segregation of the centrosome. CETN2 has been shown to interact with XPC and SFI1. GRCh38: Ensembl release 89: ENSG00000147400 – Ensembl, May 2017...
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Chloroethylating Anticancer Drugs: p53 Determines the Switch by Regulating xpc, ddb2, and DNA Double-Strand Breaks". Cancer Research. 67 (24). American...
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