• Thumbnail for ADAM12
    humans is encoded by the ADAM12 gene. ADAM12 has two splice variants: ADAM12-L, the long form, has a transmembrane region and ADAM12-S, a shorter variant...
    13 KB (1,579 words) - 07:19, 29 April 2024
  • Thumbnail for Metalloproteinase
    protease enzyme whose catalytic mechanism involves a metal. An example is ADAM12 which plays a significant role in the fusion of muscle cells during embryo...
    7 KB (759 words) - 02:51, 1 April 2024
  • Thumbnail for Myogenesis
    Fusion in humans is aided by a set of metalloproteinases coded for by the ADAM12 gene, and a variety of other proteins. Fusion involves recruitment of actin...
    24 KB (2,738 words) - 02:09, 3 September 2024
  • HGNC:216 Q13443 253 ADAM10 HGNC:188 O14672 254 ADAM11 HGNC:189 O75078 255 ADAM12 HGNC:190 O43184 256 ADAM15 HGNC:193 Q13444 257 ADAM17 HGNC:195 P78536 258...
    277 KB (17 words) - 18:34, 6 October 2024
  • Thumbnail for SH3PXD2A
    (2005). "Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity". Proc. Natl. Acad. Sci. U.S.A. 102 (8): 3058–63...
    3 KB (450 words) - 03:17, 8 August 2022
  • Thumbnail for ADAM (protein)
    region of chromosome 17q21 previously defined by tumor deletion mapping. ADAM12 ADAM12, a metalloprotease that binds insulin growth factor binding protein-3...
    11 KB (669 words) - 01:06, 29 November 2023
  • Satoshi Ansai, Masato Kinoshita and Atsuko Sehara-Fujisawa. 58 409-421 2016 ADAM12-deficient zebrafish exhibit retardation in body growth at the juvenile stage...
    18 KB (298 words) - 10:59, 29 January 2024
  • Thumbnail for LRP1
    have been implicated in the proteolytic cleavage of LRP1 such as ADAM10, ADAM12, ADAM17 and MT1-MMP. LRP1 is also continuously endocytosed from the membrane...
    32 KB (3,450 words) - 14:57, 7 September 2024
  • Thumbnail for IGFBP3
    IGF1R and promote cell survival. IGFBP3 has been shown to interact with: ADAM12 ADAM28 COL1A1 FN1 IGFALS IGF1, IGF2 HSPA5 Humanin PLG RXRA TF KPNB1 PRKDC...
    39 KB (4,717 words) - 13:09, 2 June 2024
  • Thumbnail for Alpha-actinin-2
    Alpha-actinin 2 has been shown to interact with KCNA5, DLG1, DISC1, MYOZ1, GRIN2B, ADAM12, ACTN3, MYPN, PDLIM3, PKN, MYOT, TTN, NMDAR, SYNPO2, LDB3, and FATZ. The...
    21 KB (2,601 words) - 17:21, 3 December 2023
  • Thumbnail for PACSIN3
    PMID 12477932. Mori S, Tanaka M, Nanba D, et al. (2003). "PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal...
    5 KB (651 words) - 18:52, 2 October 2024
  • Thumbnail for PIK3R1
    are associated to SHORT syndrome. PIK3R1 has been shown to interact with: ADAM12, BCAR1, CBLB, CD117, CD28, CD7, CENTG1, CBL, EPHA2, EPOR, ERBB3, EZR, FCGR2A...
    28 KB (3,136 words) - 20:06, 8 April 2024