In eukaryotic cells, an aggresome refers to an aggregation of misfolded proteins in the cell, formed when the protein degradation system of the cell is...
13 KB (1,654 words) - 14:17, 13 August 2023
were shortened by mutations. Lewy bodies are believed to represent an aggresome response in the cell. When misfolded proteins aggregate, or clump together...
15 KB (1,687 words) - 22:41, 1 October 2024
some are not. Note the following four examples: HDAC6 is associated with aggresomes. Misfolded protein aggregates are tagged by ubiquitination and removed...
31 KB (3,181 words) - 07:12, 12 August 2024
rely on cholesteryl esters derived from LDL. Vimentin plays a role in aggresome formation, where it forms a cage surrounding a core of aggregated protein...
23 KB (2,523 words) - 03:59, 5 September 2024
"The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation". Journal of Cell Science. 115 (Pt 14): 2907–2918. doi:10.1242/jcs...
39 KB (4,414 words) - 15:09, 11 September 2024
viral factories of the ASFV viroplasm is very similar to the aggresome formation. An aggresome is a perinuclear site where misfolded proteins are transported...
16 KB (1,652 words) - 07:46, 16 January 2024
overworked. In mammalian cells, these protein aggregates are termed "aggresomes" and they are formed when the cell is diseased. This is because aggregates...
24 KB (2,885 words) - 02:45, 28 March 2024
reticulum stress response (ER stress) Mitochondrial unfolded protein response Aggresome PERK inhibitors Hetz C, Papa FR (January 2018). "The Unfolded Protein...
31 KB (3,579 words) - 07:01, 26 July 2024
endosome PML body late endosome P-body phagophore assembly site nucleoplasm aggresome autophagosome amphisome endoplasmic reticulum inclusion body lysosome...
13 KB (1,644 words) - 03:32, 23 December 2023
bodies in neurodegenerative diseases are aggregates of misfolded proteins (aggresomes) and are hallmarks of many of these diseases, including Lewy bodies in...
23 KB (2,583 words) - 18:41, 21 August 2024
perinuclear region of cytoplasm nucleus Lewy body SCF ubiquitin ligase complex aggresome endoplasmic reticulum Golgi apparatus Parkin-FBXW7-Cul1 ubiquitin ligase...
47 KB (5,731 words) - 11:29, 22 June 2024
efficacy of mammalian cells may be limited by epigenetic gene silencing and aggresome formation (recombinant protein aggregation). For mammalian cells, synthesised...
66 KB (6,722 words) - 03:17, 30 June 2024
function proteasome binding protein binding Cellular component cytoplasm aggresome nucleus fibrillar center cytosol Biological process positive regulation...
17 KB (2,244 words) - 11:45, 4 January 2024
nucleus kinetochore centrosome rough endoplasmic reticulum dendritic shaft aggresome cell surface membrane-bounded organelle endoplasmic reticulum membrane...
25 KB (3,113 words) - 11:23, 31 December 2023
membrane membrane intracellular membrane-bounded organelle plasma membrane aggresome ciliary membrane clathrin-coated pit AP-2 adaptor complex clathrin-coated...
11 KB (1,326 words) - 02:47, 19 December 2023
autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS). Autophagy, 7: 29–31. Fujita K, Xiao Q...
15 KB (1,517 words) - 13:08, 20 November 2023
novo purine biosynthesis. However, nocodazole also blocks formation of aggresomes, complicating interpretation of these observations. Partial inhibition...
17 KB (1,672 words) - 04:19, 16 September 2024
binding Cellular component cytoplasm cytosol endosome membrane nucleoplasm aggresome Biological process phosphorylation positive regulation of interferon-alpha...
20 KB (2,296 words) - 02:36, 29 November 2023
ubiquitin-dependent protein catabolic process protein hexamerization aggresome assembly flavin adenine dinucleotide catabolic process proteasome-mediated...
49 KB (5,868 words) - 06:02, 3 June 2024
clathrin-coated vesicle cytoplasm cytoplasmic vesicle nucleus cytosol nucleoplasm aggresome lateral plasma membrane nuclear body Biological process non-canonical...
9 KB (1,105 words) - 01:36, 29 May 2023
component cytosol ESC/E(Z) complex intracellular anatomical structure aggresome perinuclear region of cytoplasm peroxisome cytoplasm Biological process...
12 KB (1,318 words) - 15:09, 3 December 2023
ATPase activity helicase activity hydrolase activity Cellular component aggresome nucleus nucleoplasm cytosol site of DNA damage chromosome Biological process...
4 KB (595 words) - 11:13, 4 March 2023
component transcription repressor complex nucleus nucleoplasm cytosol aggresome cytoplasm Biological process positive regulation of brown fat cell differentiation...
12 KB (1,680 words) - 14:26, 27 January 2024
nucleus multivesicular body cell projection microtubule associated complex aggresome dynein complex histone deacetylase complex perikaryon axon inclusion body...
15 KB (1,738 words) - 07:16, 11 March 2024
binding Cellular component cytoplasm polysome membrane plasma membrane aggresome membrane raft extracellular exosome nucleus polysomal ribosome extracellular...
9 KB (1,045 words) - 02:36, 17 April 2022
follicular lymphoma in apparently healthy individuals, and of dendritic cell aggresome-like induced structures (DALIS) in dendritic cells, thought to play an...
17 KB (1,600 words) - 07:39, 6 July 2024
3'-5'-exoribonuclease activity RNA binding Cellular component membrane aggresome nucleolus nucleus nucleoplasm Biological process RNA processing regulation...
9 KB (1,022 words) - 12:32, 24 January 2024
membrane focal adhesion plasma membrane sarcoplasmic reticulum nucleoplasm aggresome cell junction myofibril Z discdkac meiotic nuclear membrane microtubule...
9 KB (1,178 words) - 23:06, 27 December 2023
region cytoskeleton nucleus kinetochore axon cytoplasm cytoplasm cytosol aggresome perinuclear region of cytoplasm nuclear envelope nucleoplasm spindle nuclear...
11 KB (1,428 words) - 11:43, 4 March 2023
neuron projection cytoskeleton presynaptic membrane mitochondrion cytosol aggresome synaptic vesicle trans-Golgi network membrane postsynaptic early endosome...
13 KB (1,480 words) - 19:51, 8 April 2024