The alpha-2A adrenergic receptor (α2A adrenoceptor), also known as ADRA2A, is an α2 adrenergic receptor, and also denotes the human gene encoding it....
12 KB (1,303 words) - 04:16, 13 August 2024
The alpha-2C adrenergic receptor (α2C adrenoceptor), also known as ADRA2C, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding...
13 KB (1,540 words) - 04:17, 8 March 2024
The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein. It consists...
25 KB (2,231 words) - 08:33, 22 August 2024
Alpha-adrenergic agonists are a class of sympathomimetic agents that selectively stimulates alpha adrenergic receptors. The alpha-adrenergic receptor...
13 KB (1,364 words) - 03:02, 21 August 2024
adrenergic receptor (β1 adrenoceptor), also known as ADRB1, can refer to either the protein-encoding gene (gene ADRB1) or one of the four adrenergic receptors...
31 KB (3,743 words) - 00:48, 23 July 2024
Francke K, Pittrow D, Kirch W (January 2004). "Mechanisms of beta-adrenergic receptor-mediated venodilation in humans". Clinical Pharmacology and Therapeutics...
44 KB (4,094 words) - 00:00, 8 August 2024
The alpha-2B adrenergic receptor (α2B adrenoceptor), is a G-protein coupled receptor. It is a subtype of the adrenergic receptor family. The human gene...
15 KB (1,754 words) - 20:51, 13 August 2023
2A or II-A may refer to: Alberta Highway 2A Massachusetts Route 2A 2A self-cleaving peptides Alpha-2A adrenergic receptor IARC group 2A Keratin 2A Transcription...
796 bytes (130 words) - 21:48, 20 October 2023
Guanfacine (category Alpha-2 adrenergic receptor agonists)
Extended-Release Tablets (Intuniv), a Nonstimulant Selective Alpha(2A)-Adrenergic Receptor Agonist For Attention-Deficit/Hyperactivity Disorder". P & T...
43 KB (3,962 words) - 20:10, 8 August 2024
the histamine H2 receptor, 964 nM for the alpha-2A adrenergic receptor, 115 nM for the serotonin transporter, 4519 nM for the σ1 receptor, and 525 nM for...
6 KB (565 words) - 07:27, 13 October 2023
G-protein-coupled receptor kinase 2 (GRK2) is an enzyme that in humans is encoded by the ADRBK1 gene. GRK2 was initially called Beta-adrenergic receptor kinase (βARK...
14 KB (1,637 words) - 11:17, 19 June 2022
cortex function, including guanfacine, which acts through the alpha-2A adrenergic receptor. A downstream target of this drug, the HCN channel, is one of...
47 KB (5,356 words) - 07:14, 28 May 2024
Oxymetazoline (category Alpha-1 adrenergic receptor agonists)
and activates α1 adrenergic receptors and α2 adrenergic receptors, most notably. One study classified it in the following order: α(2A) > α(1A) ≥ α(2B)...
15 KB (1,266 words) - 05:55, 14 May 2024
(November 2008). "Serotonin 5-hydroxytryptamine(2A) receptor activation suppresses tumor necrosis factor-alpha-induced inflammation with extraordinary potency"...
87 KB (9,542 words) - 16:05, 16 August 2024
A (Sep 1994). "Multiple alpha-2 adrenergic receptor subtypes. II. Evidence for a role of rat R alpha-2A adrenergic receptors in the control of nociception...
8 KB (921 words) - 04:12, 21 August 2022
Lofexidine (category Alpha-2 adrenergic receptor agonists)
symptoms of opioid withdrawal. It is taken by mouth. It is an α2A adrenergic receptor agonist. It was approved for use by the Food and Drug Administration...
15 KB (1,395 words) - 23:58, 26 December 2023
Lisuride (category Alpha-1 blockers)
and antagonist of dopamine, serotonin, and adrenergic receptors. Activation of specific dopamine receptors is thought to be responsible for its effectiveness...
27 KB (2,067 words) - 03:25, 31 January 2024
George AL, McNamara JO (December 1998). "Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy". Neurology...
12 KB (1,532 words) - 08:18, 24 December 2023
receptors D1 and D2, histamine receptor H1, and A1 adrenoreceptors. Ketanserin Antihypertensive. Blocks 5-HT2A, 5-HT2C and Alpha 1 (A1) adrenoreceptors. Risperidone...
5 KB (506 words) - 03:46, 13 August 2023
Agonist-antagonist (section Synaptic receptors)
Piergentili A, Quaglia W, et al. (November 2010). "Fruitful adrenergic α(2C)-agonism/α(2A)-antagonism combination to prevent and contrast morphine tolerance...
7 KB (715 words) - 18:05, 18 February 2024
Ergotamine (category Alpha-2 adrenergic receptor agonists)
Ergotamine interacts with serotonin, adrenergic, and dopamine receptors. It is an agonist of serotonin receptors including the 5-HT1 and 5-HT2 subtypes...
22 KB (1,307 words) - 10:49, 1 July 2024
from that of other structurally determined GPCRs (i.e., the beta-2 adrenergic receptor and rhodopsin). Below this primary (orthosteric) binding pocket lies...
46 KB (5,102 words) - 19:50, 8 June 2024
Carvedilol (category Alpha-1 blockers)
enantiomers have alpha-blocking activity. The affinity (Ki) of carvedilol for the β-adrenergic receptors is 0.32 nM for the human β1-adrenergic receptor and 0.13...
33 KB (2,893 words) - 03:33, 19 August 2024
inhibitor but also has affinity as a TAAR1 receptor agonist (3.3 μM EC50), an Alpha-2A adrenergic receptor agonist (0.49 μM Ki) and as a binding agent...
5 KB (418 words) - 21:51, 16 May 2024
PS75 (category Alpha-2 adrenergic receptor agonists)
acts as a functionally selective alpha-2A adrenergic agonist, with a Ki of 8.2nM and an EC50 of 4.8nM at the α2A receptor. In animal studies it was found...
2 KB (131 words) - 22:09, 7 November 2023
neurotransmitter that induces vasoconstriction by binding to alpha-adrenergic receptors on smooth muscle cells. The narrowing of blood vessels leads to...
19 KB (1,648 words) - 12:50, 25 June 2024
Autoreceptor (category Receptors)
clinically important are alpha 2(adrenergic receptor subtype 2), H 3(histamine receptor subtype 3), 5 HT 1(serotonin receptor subtype 1). In which respective...
8 KB (807 words) - 15:33, 16 April 2024
Ibopamine (category Alpha-1 adrenergic receptor agonists)
hydrolysed to epinine, ibopamine is able to stimulate the alpha-adrenergic and D1 dopaminergic receptors, thereby exhibiting mydriatic effects. In some randomized...
9 KB (849 words) - 03:21, 20 October 2023
degradation of UCH-L1. Ubiquitin carboxyl-terminal esterase L3—the gene UCHL3 Alpha synuclein Parkinson disease Proteasome GRCh38: Ensembl release 89: ENSG00000154277...
21 KB (2,637 words) - 03:01, 26 November 2023
Piribedil (category Alpha-2 blockers)
and piperazine derivative which acts as a D2 and D3 receptor agonist. It also has α2-adrenergic antagonist properties. Treatment of Parkinson's disease...
11 KB (892 words) - 05:57, 18 March 2024