Alpha-synuclein (aSyn) is a protein that, in humans, is encoded by the SNCA gene. Alpha-synuclein is a neuronal protein that regulates synaptic vesicle...

Neuronal Alpha-Synuclein Disease (NSD) is a proposed new combined definition of Parkinson's disease and Dementia with Lewy bodies based on biology instead...

this cell death is poorly understood but involves the aggregation of alpha-synuclein into Lewy bodies within neurons. Other potential factors involve genetic...

radiating fibrils, the primary structural component of which is alpha-synuclein (α-synuclein). While similar in many other respects, cortical Lewy bodies...

An anti-α-synuclein drug, or an α-synuclein inhibitor, is a drug which blocks or inhibits α-synuclein. α-Synuclein is a protein which is thought to be...

sometimes initial clinical manifestation of the disorder. A prion of the alpha-synuclein protein within affected neurons may cause MSA. About 55% of MSA cases...

diseases characterised by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells. There are three main...

synucleinopathy, meaning that it is characterized by abnormal deposits of alpha-synuclein protein in the brain. The synucleinopathies include Parkinson's disease...

lungs and kidney, resulting high toxicity; as well, as death. Alpha-synuclein (α-synuclein) is an endogenous protein that is encoded by the SNCA gene and...

electric ray. The synuclein family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. Interest in the synuclein family began...

Parkinson's disease-associated mutant alpha-synucleins through axons of cultured neurons. Membrane damage by alpha-synuclein could be another Parkinson's disease...

regarded a late-onset neurodegenerative condition characterised by alpha-synuclein-enriched Lewy bodies, autosomal recessive PD due to parkin mutations...

that cuminaldehyde, as a small molecule, inhibits the fibrillation of alpha-synuclein, which, if aggregated, forms insoluble fibrils in pathological conditions...

diseases were thought to be caused by PrP until 2015 when a prion form of alpha-synuclein was linked to multiple system atrophy (MSA). Prions are also linked...

Parkinson's disease-associated deglycase (PARK7), PRKN, PINK1, or SNCA (alpha-synuclein). Exposure to pesticides, metals, solvents, and other toxicants has...

oxidative stress can be repaired by processes modulated by alpha-synuclein. Alpha synuclein is expressed in the substantia nigra, but its DNA repair function...

led by Maria Grazia Spillantini reported on alpha-synuclein deposits in Lewy bodies as well as alpha-synuclein inclusions in other neurodegenerative disorders...

in figure) and the presence of aggregated alpha-synuclein. Under physiological conditions, alpha-synuclein, a protein encoded by the SNCA gene, is found...

Trust intermediate clinical fellowship to study the misfolding of alpha-synuclein in Parkinson's disease, and how this misfolding causes neurotoxicity...

block the synaptotoxic actions of oligomeric forms of amyloid beta and alpha-synuclein. In preclinical studies, RAP-103 has also been shown to prevent and...

mutation (PARK1) in the brain protein, alpha-synuclein. Within days of the publication of the PARK1 findings, alpha-synuclein was discovered to be the major component...

human neuroglioma cells transfected with mutant alpha-synuclein led to 50% less oligomeric alpha-synuclein species, pointing towards the possibility that...

University of Cambridge. She is most noted for identifying the protein alpha-synuclein as the major component of Lewy bodies, the characteristic protein deposit...

proteins. The protein alpha-synuclein has increased presence in the brains of Parkinson's Disease patients and, as α-synuclein is insoluble, it aggregates...

and lifespan in mouse models of Alzheimer's disease; reduction in alpha-synuclein aggregation and increase in healthspan and lifespan in a C.elegans...

The Epstein–Barr virus has been implicated in disorders related to alpha-synuclein aggregation (e.g. Parkinson's disease, dementia with Lewy bodies, and...

One mechanism consists of an abnormal accumulation of the protein alpha-synuclein bound to ubiquitin in the damaged cells. This protein accumulation...

Beta-synuclein is a protein that in humans is encoded by the SNCB gene. The protein encoded by this gene is highly homologous to alpha-synuclein. These...

Martin; Biere, Anja-Leona (17 July 2023). "In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson's...

neurites have been found to develop from the aggregation of misfolded alpha-synuclein, a protein thought to assist in neurotransmitter release and vesicle...