Alpha-synuclein (aSyn) is a protein that, in humans, is encoded by the SNCA gene. Alpha-synuclein is a neuronal protein that regulates synaptic vesicle...

radiating fibrils, the primary structural component of which is alpha-synuclein (α-synuclein). While similar in many other respects, cortical Lewy bodies...

control. The cause of this cell death is poorly understood but involves alpha-synuclein aggregation into Lewy bodies within the neurons. Other possible factors...

sometimes initial clinical manifestation of the disorder. A prion of the alpha-synuclein protein within affected neurons may cause MSA. About 55% of MSA cases...

electric ray. The synuclein family includes three known proteins: alpha-synuclein, beta-synuclein, and gamma-synuclein. Interest in the synuclein family began...

diseases characterised by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells. There are three main...

synucleinopathy, meaning that it is characterized by abnormal deposits of alpha-synuclein protein in the brain. The synucleinopathies include Parkinson's disease...

Parkinson's disease-associated mutant alpha-synucleins through axons of cultured neurons. Membrane damage by alpha-synuclein could be another Parkinson's disease...

lungs and kidney, resulting high toxicity; as well, as death. Alpha-synuclein (α-synuclein) is an endogenous protein that is encoded by the SNCA gene and...

oxidative stress can be repaired by processes modulated by alpha-synuclein. Alpha synuclein is expressed in the substantia nigra, but its DNA repair function...

led by Maria Grazia Spillantini reported on alpha-synuclein deposits in Lewy bodies as well as alpha-synuclein inclusions in other neurodegenerative disorders...

that cuminaldehyde, as a small molecule, inhibits the fibrillation of alpha-synuclein, which, if aggregated, forms insoluble fibrils in pathological conditions...

regarded a late-onset neurodegenerative condition characterised by alpha-synuclein-enriched Lewy bodies, autosomal recessive PD due to parkin mutations...

diseases were thought to be caused by PrP until 2015 when a prion form of alpha-synuclein was linked to multiple system atrophy (MSA). Prions are also linked...

in figure) and the presence of aggregated alpha-synuclein. Under physiological conditions, alpha-synuclein, a protein encoded by the SNCA gene, is found...

Alzheimer's and Parkinson's disease, particularly surrounding the alpha-synuclein protein. The dossier was sent to the HHS Office of Research Integrity...

Martin; Biere, Anja-Leona (17 July 2023). "In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson's...

human neuroglioma cells transfected with mutant alpha-synuclein led to 50% less oligomeric alpha-synuclein species, pointing towards the possibility that...

Parkinson's disease-associated deglycase (PARK7), PRKN, PINK1, or SNCA (alpha-synuclein). Exposure to pesticides, metals, solvents, and other toxicants has...

One mechanism consists of an abnormal accumulation of the protein alpha-synuclein bound to ubiquitin in the damaged cells. This protein accumulation...

mutation (PARK1) in the brain protein, alpha-synuclein. Within days of the publication of the PARK1 findings, alpha-synuclein was discovered to be the major component...

An anti-α-synuclein drug, or an α-synuclein inhibitor, is a drug which blocks or inhibits α-synuclein. α-Synuclein is a protein which is thought to be...

Trust intermediate clinical fellowship to study the misfolding of alpha-synuclein in Parkinson's disease, and how this misfolding causes neurotoxicity...

University of Cambridge. She is most noted for identifying the protein alpha-synuclein as the major component of Lewy bodies, the characteristic protein deposit...

proteins. The protein alpha-synuclein has increased presence in the brains of Parkinson's Disease patients and, as α-synuclein is insoluble, it aggregates...

The Epstein–Barr virus has been implicated in disorders related to alpha-synuclein aggregation (e.g. Parkinson's disease, dementia with Lewy bodies, and...

and lifespan in mouse models of Alzheimer's disease; reduction in alpha-synuclein aggregation and increase in healthspan and lifespan in a C.elegans...

neurites have been found to develop from the aggregation of misfolded alpha-synuclein, a protein thought to assist in neurotransmitter release and vesicle...

of UCH-L1. Ubiquitin carboxyl-terminal esterase L3—the gene UCHL3 Alpha synuclein Parkinson disease Proteasome GRCh38: Ensembl release 89: ENSG00000154277...

MG; Crowther, RA; Jakes, R; Hasegawa, M; Goedert, M (26 May 1998). "alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and...