Autophagy protein 5 (ATG5) is a protein that, in humans, is encoded by the ATG5 gene located on chromosome 6. It is an E3 ubi autophagic cell death. ATG5...
22 KB (2,808 words) - 09:48, 15 April 2024
Autophagy (or autophagocytosis; from the Greek αὐτόφαγος, autóphagos, meaning "self-devouring" and κύτος, kýtos, meaning "hollow") is the natural, conserved...
77 KB (9,111 words) - 09:15, 16 October 2024
Autophagy-related protein 101 also known as ATG101 is a protein that in humans is encoded by the C12orf44 gene (chromosome 12 open reading frame 44)....
6 KB (840 words) - 12:20, 14 February 2023
MTOR (redirect from FK506 binding protein 12-rapamycin associated protein 1)
serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription...
119 KB (12,658 words) - 19:25, 19 September 2024
Autophagy-related protein 13 also known as ATG13 is a protein that in humans is encoded by the KIAA0652 gene. ATG13 is an autophagy factor required for...
7 KB (840 words) - 13:37, 18 January 2024
which encodes an important regulator of the autophagy pathway, the ectopic P-granules autophagy protein 5, involved in the formation of lysosomes. EPG5...
11 KB (1,428 words) - 15:52, 3 February 2024
selective autophagy is a cellular process for the selective, ubiquitin-dependent degradation of chaperone-bound proteins in lysosomes. Autophagy (Greek:...
11 KB (1,144 words) - 19:52, 3 May 2024
Chaperone-mediated autophagy (CMA) refers to the chaperone-dependent selection of soluble cytosolic proteins that are then targeted to lysosomes and directly...
31 KB (3,623 words) - 00:33, 22 June 2024
described to be necessary for mitophagy (autophagy of mitochondria). However, how loss of function of the parkin protein leads to dopaminergic cell death in...
47 KB (5,731 words) - 11:29, 22 June 2024
macroautophagy, when protein aggregates are enclosed by double membrane and degraded afterwards. They are also involved in a special type of autophagy called chaperone-mediated...
49 KB (5,533 words) - 10:41, 19 July 2024
autophagy. There are two main protein quality control systems in the cell that are responsible for eliminating protein aggregates. Misfolded proteins...
24 KB (2,885 words) - 02:45, 28 March 2024
Serine/threonine-protein kinase ULK1 is an enzyme that in humans is encoded by the ULK1 gene. Unc-51-like autophagy-activating kinases 1 and 2 (ULK1/2)...
17 KB (1,930 words) - 14:55, 11 August 2024
Cell biology (section Autophagy)
virulence proteins that prevent autophagy, while others utilize autophagy elements for intracellular development or cellular splitting. Macro autophagy, micro...
41 KB (5,248 words) - 02:59, 24 October 2024
born February 9, 1945) is a Japanese cell biologist specializing in autophagy, the process that cells use to destroy and recycle cellular components...
11 KB (1,469 words) - 07:40, 4 October 2024
Prion (redirect from Cellular prion protein)
A prion /ˈpriːɒn/ is a misfolded protein that induces misfolding in normal variants of the same protein, leading to cellular death. Prions are responsible...
99 KB (10,732 words) - 17:23, 27 October 2024
MAP1LC3B (section The ATG8 protein family)
a microtubule associated protein in rat brain. However it was later found that the primary function of LC3 is in autophagy, a process that involves the...
40 KB (1,799 words) - 22:23, 2 December 2023
Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress. The process...
33 KB (4,128 words) - 02:28, 29 June 2024
BECN1 (category Human proteins)
Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is a mammalian ortholog of the yeast autophagy-related gene 6 (Atg6) and BEC-1...
13 KB (1,482 words) - 16:14, 15 March 2024
SNARE proteins – "SNAP REceptors" – are a large protein family consisting of at least 24 members in yeasts and more than 60 members in mammalian and plant...
53 KB (6,592 words) - 12:55, 13 October 2024
Autophagy related 16 like 1 is a protein that in humans is encoded by the ATG16L1 gene. This protein is characterized as a subunit of the autophagy-related...
16 KB (1,731 words) - 06:41, 27 September 2024
The tau proteins (abbreviated from tubulin associated unit) form a group of six highly soluble protein isoforms produced by alternative splicing from the...
55 KB (6,241 words) - 00:08, 3 October 2024
5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular...
65 KB (7,149 words) - 04:45, 26 August 2024
Self-cannibalism (redirect from Autophagy (feeding))
autophagy, which specifically denotes the normal process of self-degradation by cells. While typically used only for this specific process, autophagy...
13 KB (1,397 words) - 13:14, 20 September 2024
Autophagy related 7 is a protein in humans encoded by ATG7 gene. Related to GSA7; APG7L; APG7-LIKE. ATG 7, present in both plant and animal genomes, acts...
7 KB (978 words) - 08:08, 18 August 2023
a specific composition, of both its membrane proteins and its lumenal proteins. The lumen's pH (~4.5–5.0) is optimal for the enzymes involved in hydrolysis...
43 KB (4,709 words) - 13:50, 12 October 2024
ATG8 (section In autophagy)
Autophagy-related protein 8 (Atg8) is a ubiquitin-like protein required for the formation of autophagosomal membranes. The transient conjugation of Atg8...
18 KB (2,085 words) - 18:55, 25 April 2024
neuronal death in Parkinson's Disease include protein aggregation in Lewy bodies, disruption of autophagy, changes in cell metabolism or mitochondrial...
19 KB (2,216 words) - 15:41, 28 March 2024
Sequestosome 1 (redirect from Sequestosome-1 protein)
an autophagosome cargo protein that targets other proteins that bind to it for selective autophagy. By interacting with GATA4 and targeting it for degradation...
13 KB (1,644 words) - 03:32, 23 December 2023
BNIP3 (category Protein families)
"Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy". The Journal...
21 KB (2,687 words) - 18:40, 24 September 2024
X-linked myopathy with excessive autophagy (XMEA) is a rare childhood onset disease characterized by slow progressive vacuolation and atrophy of skeletal...
4 KB (405 words) - 09:53, 16 June 2023