encoded by the BCL6 gene. BCL6 is a master transcription factor for regulation of T follicular helper cells (TFH cells) proliferation. BCL6 has three evolutionary...

interact with and transcriptionally repress BCL6. Small-molecule compounds, such as synthetic peptides that target BCL6 and corepressor interactions, as well...

used in lymphocyte predominant Hodgkin lymphoma with encouraging results. BCL6 gene rearrangements have been frequently observed. B symptoms are uncommon...

lymph node, CD40-CD40L ligation, NF-kB signaling and expression of IRF4 and BCL6. GC B cells cycle through the two distinct zones of the germinal center:...

proteins, Bcl-2-associated X protein and Bcl-2 homologous antagonist killer. BCL6: This genes' product, Bcl-6, is a repressor of transcription that regulates...

ligase, FBXO11 causes ubiquitination of BCL6 which causes it to be targeted for proteasome degradation. BCL6 normally helps B cells mature in the germinal...

in p21 and p27 HDAC2 1 Nucleus Ubiquitous Glucocorticoid receptor, YY1, BCL6, STAT3 – Cardiac defect HDAC3 1 Nucleus Ubiquitous SHP, YY1, GATA1, RELA...

lymphoma (CD10+ DLBCL) Marker for germinal center phenotype (CD10, HGAL, BCL6, CD38) are considered a favorable prognostic factor, but CD10+, BCL2+ tumors...

High-grade B-cell lymphoma High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements High-grade B-cell lymphoma, NOS B-cell lymphoma, unclassifiable...

shown to be repressed by BCL6, a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by...

plasma cells is dependent upon the transcription factors Blimp-1/PRDM1, BCL6, and IRF4. Unlike their precursors, plasma cells cannot switch antibody classes...

malignancies. Members include: CCND1 (also known as "BCL1") BCL2 BCL3 BCL5 BCL6, BCL6B BCL7A, BCL7B, BCL7C BCL8 BCL9 BCL10 BCL11A, BCL11B Bcl-2 family v...

CREB-binding protein, EP300, beta-2 microglobulin genes; translocations of the BCL6 and BCL2 genes; and losses of PRDM1 and TNFAIP3 genes. There is an important...

numerous mammals for which complete genome data are available. Like BCL3, BCL5, BCL6, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma. The two...

on the short arm of the X chromosome (Xp11.4). This protein encodes the BCL6 corepressor, but little is currently known about its function. The inheritance...

cases, they also express classic B cell antigenic proteins such as CD20, BCL6, and CD15. The viral proteins may be responsible for activating their infected...

protein that in humans is encoded by the BCL10 gene. Like BCL2, BCL3, BCL5, BCL6, BCL7A, and BCL9, it has clinical significance in lymphoma. Bcl10 was identified...

C2H2 ZF Known motif – High-throughput in vitro [67] GTGAACGBNDNNVCTACAC BCL6 ENSG00000113916 C2H2 ZF Known motif – High-throughput in vitro [68] YGCTTTCKAGGAAH...

Well established targets of FBXO11 include BCL6, CDT2, and Snail. Inactivation of FBXO11-mediated BCL6 degradation has been shown to contribute to abnormal...

BI-3802 as a molecular glue inducing the polymerization and degradation of BCL6. Additionally, chemogenomic screening revealed structurally diverse molecular...

IRF4 frequently cooperates with the cofactors B-cell lymphoma 6 protein (BCL6) and nuclear factor of activated T-cells (NFATs). IRF4 expression is limited...

protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal...

that controls the nuclear residence of p50 NF-kappa B. Like BCL2, BCL5, BCL6, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma. BCL3 has...

HGNC:16657 Q9BZR8 1479 BCL2L15 HGNC:33624 Q5TBC7 1480 BCL3 HGNC:998 P20749 1481 BCL6 HGNC:1001 P41182 1482 BCL6B HGNC:1002 Q8N143 1483 BCL7A HGNC:1004 Q4VC05...

"Molecular cytogenetic analysis of chromosomal breakpoints in the IGH, MYC, BCL6, and MALT1 gene loci in primary cutaneous B-cell lymphomas". J. Invest. Dermatol...

Immunochemical analyses indicate that the latter cells express CD20, CD10, BCL6, and CD79A and have a very low proliferation rate as defined by the intensity...

function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated....

Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6". Immunity. 34 (6): 932–946. doi:10.1016/j.immuni.2011.03.023. PMC 3124577...

do not express the cyclin D1 marker protein., the T-cell marker, CD10, or BCL6. There are various EMZL subtypes based on the organs they involve. Almost...

directly and indirectly represses anti-osteoclastogenesis genes such as Bcl6, IRF8, and MafB, helping monocytes differentiate into osteoclasts. In mice...