encoded by the BCL6 gene. BCL6 is a master transcription factor for regulation of T follicular helper cells (TFH cells) proliferation. BCL6 has three evolutionary...
20 KB (2,414 words) - 11:10, 15 July 2024
interact with and transcriptionally repress BCL6. Small-molecule compounds, such as synthetic peptides that target BCL6 and corepressor interactions, as well...
24 KB (2,462 words) - 05:45, 28 October 2024
lymph node, CD40-CD40L ligation, NF-kB signaling and expression of IRF4 and BCL6. GC B cells cycle through the two distinct zones of the germinal center:...
22 KB (2,792 words) - 06:20, 3 March 2024
used in lymphocyte predominant Hodgkin lymphoma with encouraging results. BCL6 gene rearrangements have been frequently observed. B symptoms are uncommon...
19 KB (1,893 words) - 03:08, 15 July 2024
proteins, Bcl-2-associated X protein and Bcl-2 homologous antagonist killer. BCL6: This genes' product, Bcl-6, is a repressor of transcription that regulates...
69 KB (8,143 words) - 23:37, 9 November 2024
ligase, FBXO11 causes ubiquitination of BCL6 which causes it to be targeted for proteasome degradation. BCL6 normally helps B cells mature in the germinal...
40 KB (4,609 words) - 18:13, 1 December 2024
in p21 and p27 HDAC2 1 Nucleus Ubiquitous Glucocorticoid receptor, YY1, BCL6, STAT3 – Cardiac defect HDAC3 1 Nucleus Ubiquitous SHP, YY1, GATA1, RELA...
31 KB (3,181 words) - 07:12, 12 August 2024
plasma cells is dependent upon the transcription factors Blimp-1/PRDM1, BCL6, and IRF4. Unlike their precursors, plasma cells cannot switch antibody classes...
24 KB (2,793 words) - 18:41, 30 May 2024
is accompanied by a translocation of BCL2 or BCL6; and as triple hit when MYC-R includes both BCL2 and BCL6. Double and triple hit lymphoma have been recently...
64 KB (7,405 words) - 05:43, 23 December 2024
High-grade B-cell lymphoma High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements High-grade B-cell lymphoma, NOS B-cell lymphoma, unclassifiable...
24 KB (2,329 words) - 20:43, 2 October 2024
lymphoma (CD10+ DLBCL) Marker for germinal center phenotype (CD10, HGAL, BCL6, CD38) are considered a favorable prognostic factor, but CD10+, BCL2+ tumors...
23 KB (2,581 words) - 06:57, 21 July 2024
shown to be repressed by BCL6, a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by...
5 KB (658 words) - 16:31, 28 November 2023
numerous mammals for which complete genome data are available. Like BCL3, BCL5, BCL6, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma. The two...
41 KB (4,566 words) - 03:50, 16 December 2024
BI-3802 as a molecular glue inducing the polymerization and degradation of BCL6. Additionally, chemogenomic screening revealed structurally diverse molecular...
37 KB (3,822 words) - 18:34, 19 December 2024
C2H2 ZF Known motif – High-throughput in vitro [67] GTGAACGBNDNNVCTACAC BCL6 ENSG00000113916 C2H2 ZF Known motif – High-throughput in vitro [68] YGCTTTCKAGGAAH...
374 KB (81 words) - 02:10, 23 September 2023
protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal...
9 KB (1,146 words) - 22:44, 28 December 2023
protein that in humans is encoded by the BCL10 gene. Like BCL2, BCL3, BCL5, BCL6, BCL7A, and BCL9, it has clinical significance in lymphoma. Bcl10 was identified...
15 KB (1,813 words) - 14:39, 26 January 2024
CREB-binding protein, EP300, beta-2 microglobulin genes; translocations of the BCL6 and BCL2 genes; and losses of PRDM1 and TNFAIP3 genes. There is an important...
37 KB (4,783 words) - 14:57, 23 February 2024
on the short arm of the X chromosome (Xp11.4). This protein encodes the BCL6 corepressor, but little is currently known about its function. The inheritance...
4 KB (322 words) - 12:15, 25 October 2023
malignancies. Members include: CCND1 (also known as "BCL1") BCL2 BCL3 BCL5 BCL6, BCL6B BCL7A, BCL7B, BCL7C BCL8 BCL9 BCL10 BCL11A, BCL11B Bcl-2 family v...
647 bytes (59 words) - 02:16, 6 February 2024
cases, they also express classic B cell antigenic proteins such as CD20, BCL6, and CD15. The viral proteins may be responsible for activating their infected...
140 KB (16,977 words) - 09:07, 9 September 2024
Well established targets of FBXO11 include BCL6, CDT2, and Snail. Inactivation of FBXO11-mediated BCL6 degradation has been shown to contribute to abnormal...
9 KB (1,160 words) - 02:30, 30 March 2024
HGNC:16657 Q9BZR8 1479 BCL2L15 HGNC:33624 Q5TBC7 1480 BCL3 HGNC:998 P20749 1481 BCL6 HGNC:1001 P41182 1482 BCL6B HGNC:1002 Q8N143 1483 BCL7A HGNC:1004 Q4VC05...
277 KB (17 words) - 18:34, 6 October 2024
function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated....
14 KB (1,650 words) - 09:43, 23 December 2024
do not express the cyclin D1 marker protein., the T-cell marker, CD10, or BCL6. There are various EMZL subtypes based on the organs they involve. Almost...
116 KB (14,600 words) - 02:13, 16 October 2024
Immunochemical analyses indicate that the latter cells express CD20, CD10, BCL6, and CD79A and have a very low proliferation rate as defined by the intensity...
15 KB (1,896 words) - 11:50, 15 August 2024
"Molecular cytogenetic analysis of chromosomal breakpoints in the IGH, MYC, BCL6, and MALT1 gene loci in primary cutaneous B-cell lymphomas". J. Invest. Dermatol...
9 KB (1,214 words) - 04:36, 29 August 2024
IRF4 frequently cooperates with the cofactors B-cell lymphoma 6 protein (BCL6) and nuclear factor of activated T-cells (NFATs). IRF4 expression is limited...
23 KB (2,598 words) - 16:20, 1 August 2024
Beta2/NeuroD, CREB, c-Jun, C/EBPβ, NF-E2, SREBP, IRF2, Sp3, YY1, KLF13, EVI1, BCL6, HNF-4, ER81 and FOXO4 (AFX). The formation of multisubunit complexes has...
53 KB (6,150 words) - 04:41, 26 August 2024
Okada S, Hatano M, Ebara M, Saisho H, Tokuhisa T (Jul 1998). "BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor". Molecular and Cellular...
2 KB (344 words) - 19:26, 13 October 2022