by the BRD4 gene. BRD4 is a member of the BET (bromodomain and extra terminal domain) family, which also includes BRD2, BRD3, and BRDT. BRD4, similar...

of NUTM1 in band 14 on the long (or "q") arm of chromosome 15 is fused to BRD4 or BRD3, which creates a chimeric gene that encodes the BRD-NUT fusion protein...

bromodomains of Bromodomain and Extra-Terminal motif (BET) proteins BRD2, BRD3, BRD4, and BRDT, and prevent protein-protein interaction between BET proteins and...

CPI-0610 is a drug which acts as a BET inhibitor, mainly acting at the BRD2 and BRD4 subtypes. It has potential applications in the treatment of various forms...

particular cell type), immature-appearing cells containing a BRD4-NUTM1 fusion gene. BRD4 is the bromodomain-containing protein 4 gene. A fusion gene is...

inhibitor of the BET family of bromodomain proteins which include BRD2, BRD3, BRD4, and the testis-specific protein BRDT in mammals. BET inhibitors structurally...

"Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4". ACS Chemical Biology. 10 (8): 1770–7. doi:10.1021/acschembio.5b00216. PMC 4548256...

regulatory regions, BRD4 enhances activation of these DNA regions. BRD4 enhances this activation by recruiting P-TEFb; if either BRD4 or P-TEFb is not functional...

P-TEFb associates with other factors including the bromodomain protein BRD4, and is found associated with a large complex of proteins called the super...

either the HIV transactivator Tat or the bromodomain containing protein BRD4. This release leads to a conformational change in 7SK RNA and the ejection...

MK-8628) is an experimental small molecule inhibitor of BRD2, BRD3, and BRD4 under investigation for the treatment of cancer. It is in development by...

oncogene Myc, the Rett syndrome protein MECP2, and the BET bromodomain protein BRD4. In particular, the Myc protein amplifies transcription by binding to promoters...

can cooperate with the RAS gene. Expression of Myc is highly dependent on BRD4 function in some cancers. BET inhibitors have been used to successfully block...

(2015-06-18). "Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4". Chemistry & Biology. 22 (6): 755–763. doi:10.1016/j.chembiol.2015.05.009...

2018 Jan 2;215(1):51-62. doi: 10.1084/jem.20161066 "The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling...

replication. E2 also utilizes a cellular protein known as Bromodomain-4 (Brd4) to tether the viral genome to cellular chromosomes. This tethering to the...

studies of regulation in cancer cells. Kuroda's laboratory has shown that BRD4-NUT regulator leads to cancer via causing histone modification changes that...

BromoTag, a "bump-and-hole" mutated version of the second bromodomain of Brd4, Brd4-BD2 L387A, that can be highly selectively bound by tag-specific PROTAC...

gene. A marked example is CAP which can refer to any of 6 different genes (BRD4 Archived 2013-10-27 at the Wayback Machine, CAP1 Archived 2013-11-02 at the...

PMID 26119834. Zou Z, Huang B, Wu X, Zhang H, Qi J, Bradner J, et al. (May 2014). "Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated...

P25440 1653 BRD3 HGNC:1104 Q15059 1654 BRD3OS HGNC:24742 A0A1B0GUI7 1655 BRD4 HGNC:13575 O60885 1656 BRD7 HGNC:14310 Q9NPI1 1657 BRD8 HGNC:19874 Q9H0E9...

sensitive to inhibitors (such as JQ1) of a super enhancer bound protein BRD4. Embryonal RMS usually presents with a loss of heterozygosity (LOH) in the...

extraterminal domain) family. Members of this family include BRD2, BRD3, BRD4 and BRDT. However proteins such as ASH1L also contain a bromodomain. Dysfunction...

Notable transcription factors implicated in mitotic bookmarking include: BRD4 GATA1 HSP70 TFIID ESRRB Sarge, K. D.; Park-Sarge, O. K. (2005). "Gene bookmarking:...

synaptotagmin function. LY294002 is also a BET inhibitor (e.g. of BRD2, BRD3, and BRD4). It has been shown that LY294002 administration has an additive effect on...

factor that aids humans in fighting off disease and for identifying the BRD4 protein that regulates cellular and viral genes that can invoke epigenetic...

cancer drug targets. In 2011, Vakoc discovered that the epigenetic protein BRD4 was particularly important for leukemia, leading to a series of clinical...

Hurwitz J, Ozato K (September 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase"...

Aksoy, Ozlem; Bolden, Jessica E.; Chen, Chi-Chao; Fennell, Myles (2016). "BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance". Cancer Discovery...

terminal domain (BET) proteins, and in particular the BET family member BRD4. BET proteins, which contain two bromodomains, interact with acetylated lysines...