Bruton's tyrosine kinase (abbreviated Btk or BTK), also known as tyrosine-protein kinase BTK, is a tyrosine kinase that is encoded by the BTK gene in humans...

develop serious and even fatal infections. A mutation occurs at the Bruton's tyrosine kinase (Btk) gene that leads to a severe block in B cell development (at...

name: "Bruton-type agammaglobulinemia". The gene associated with this defect is also named after him: Btk, abbreviation for Bruton's tyrosine kinase. He...

ATC code L01 Antineoplastic agents is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes...

been identified that are regulated by PtdIns(3,4,5)P3, including Bruton's tyrosine kinase (BTK), General Receptor for Phosphoinositides-1 (GRP1), and the...

including tislelizumab, a checkpoint inhibitor, and zanubrutinib, a Bruton's tyrosine kinase inhibitor. On 14 November, 2024 the company announced its intention...

chronic lymphocytic leukemia (CLL). Zanubrutinib is classified as a Bruton's tyrosine kinase (BTK) inhibitor. It is given by mouth. It was approved for medical...

It is a second generation Bruton's tyrosine kinase inhibitor. Acalabrutinib blocks an enzyme called Bruton's tyrosine kinase, which helps B cells to survive...

lymphocyte proliferation and survival by binding and inhibiting Bruton's tyrosine kinase (BTK). It is taken by mouth. The most common adverse reactions...

proliferation and survival by irreversibly binding the protein Bruton's tyrosine kinase (BTK). Blocking BTK inhibits the B-cell receptor pathway, which...

rheumatoid arthritis. Tirabrutinib is an irreversible inhibitor of Bruton's tyrosine kinase. Dhillon S (June 2020). "Tirabrutinib: First Approval". Drugs....

certain eukaryotic signalling proteins. The motif is named after Bruton's tyrosine kinase (Btk), an enzyme which is essential for B cell maturation in humans...

proto-oncogene receptor tyrosine kinase rearranged during transfection (RET) inhibitor, LOXO-305, an oral Bruton's tyrosine kinase (BTK) inhibitor, and LOXO-195...

drug that is being evaluated to treat multiple sclerosis. It is a Bruton's tyrosine kinase (BTK) inhibitor. "Tolebrutinib - Sanofi". AdisInsight. Springer...

ibrutinib targets the MYD88 L265P mutation induced activation of Bruton's tyrosine kinase. In a cohort study of previously treated patients, ibrutinib induced...

Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene. HCK comprises five distinct domains which include two terminal domains...

cell surface.[supplied by OMIM] Protein kinase D1 has been shown to interact with: Bruton's tyrosine kinase, C1QBP, Centaurin, alpha 1, Metallothionein...

kurstaki (Btk), a soil-dwelling bacterium also used as an insecticide Bruton's tyrosine kinase, a protein Btk-type zinc finger or Btk motif (BM), a zinc-binding...

PDGFRA, PTGS2, TRAF2, estrogen receptor alpha, caveolin 2, PLD2, Bruton's tyrosine kinase, and SCP2. All these interactions are through a caveolin-scaffolding...

Remibrutinib is a small molecule drug that acts as a Bruton's tyrosine kinase (BTK) inhibitor. It is in development for the treatment of chronic spontaneous...

Tyrosine-protein kinase SYK, also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the SYK gene. SYK, along with ZAP70, is...

Poseltinib (HM71224, LY3337641) is an experimental Bruton's tyrosine kinase inhibitor for the treatment of rheumatoid arthritis. It was developed by Hanmi...

intracellular kinases: N-terminus – PH (pleckstrin homology domain) TH – Tec family homology domain (including Bruton's tyrosine kinase Cys-rich motif...

cases. A phase 1 clinical trial of ibrutinib – an inhibitor of Bruton's tyrosine kinase – in 13 patients reported responses in 10 (77%). Five of the responses...

to autoimmune disorders. GTF2I has been shown to interact with: Bruton's tyrosine kinase, HDAC3, Histone deacetylase 2, MAPK3, Myc, PRKG1, Serum response...

least one treatment in the past. Orelabrutinib is an inhibitor of Bruton's tyrosine kinase. Dhillon S (March 2021). "Orelabrutinib: First Approval". Drugs...

formerly ARQ 531) is a small molecule drug that works as a reversible Bruton's tyrosine kinase (BTK) inhibitor; unlike other BTK inhibitors it also works against...

four different trials of VAL-083 are registered. Ibrutinib blocks Bruton's tyrosine kinase (BTK) and is used to treat mantle cell lymphoma, chronic lymphocytic...

bacterial infections. XLA is associated with a mutation in the Bruton's tyrosine kinase (BTK) gene on the X chromosome, which is responsible for producing...

may have tumor suppressive activity through its interaction with Bruton's tyrosine kinase (Btk) and regulation of the pre-B cell checkpoint. The acidic region...